Arrestin-C - OX2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OX2 72.3
Arrestin-C 81.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM5 K 249 5x64 S16 D 244 C.S16.01
Polar TM5 K 249 5x64 S16 D 244 C.S16.01
Van-der-waals TM5 K 249 5x64 S16 D 244 C.S16.01
Van-der-waals ICL3 S 260 - s17s18 L 311 C.s17s18.40
Hydrophobic ICL2 F 162 34x53 s17s18 G 283 C.s17s18.12
Van-der-waals ICL2 F 162 34x53 s17s18 G 283 C.s17s18.12
Polar ICL3 G 257 - s17s18 E 310 C.s17s18.39
Hydrophobic ICL3 G 257 - s17s18 E 310 C.s17s18.39
Van-der-waals ICL3 G 257 - s17s18 E 310 C.s17s18.39
Hydrophobic TM6 R 299 6x30 s5s6 L 69 N.s5s6.10
Hydrophobic TM4 T 165 4x38 s17s18 R 282 C.s17s18.11
Van-der-waals TM4 T 165 4x38 s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 P 159 34x50 s15s16 S 242 C.s15s16.04
Polar ICL3 S 260 - s17s18 E 310 C.s17s18.39
Van-der-waals ICL3 S 260 - s17s18 E 310 C.s17s18.39
Polar H8 S 368 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 S 368 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 F 162 34x53 S8 L 126 N.S8.03
Polar ICL3 S 260 - S6 K 73 N.S6.03
Hydrophobic ICL3 S 260 - S6 K 73 N.S6.03
Van-der-waals ICL3 S 260 - S6 K 73 N.S6.03
Polar ICL2 P 159 34x50 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 P 159 34x50 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 M 305 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 M 305 6x36 s5s6 I 67 N.s5s6.08
Polar ICL2 S 164 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 S 164 - s5s6 R 61 N.s5s6.02
Polar TM4 A 166 4x39 s8s9 E 131 N.s8s9.05
Hydrophobic TM4 A 166 4x39 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 A 166 4x39 s8s9 E 131 N.s8s9.05
Polar TM4 K 167 4x40 s8s9 E 131 N.s8s9.05
Hydrophobic TM4 K 167 4x40 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 K 167 4x40 s8s9 E 131 N.s8s9.05
Hydrophobic TM2 T 87 2x37 s5s6 D 62 N.s5s6.03
Polar TM6 T 302 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 T 302 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 302 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic ICL3 G 257 - s15s16 L 240 C.s15s16.02
Van-der-waals ICL3 G 257 - s15s16 L 240 C.s15s16.02
Hydrophobic TM5 I 255 5x70 S6 F 71 N.S6.01
Van-der-waals TM5 I 255 5x70 S6 F 71 N.S6.01
Hydrophobic TM3 I 156 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 156 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 F 162 34x53 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 F 162 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic TM5 L 250 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 250 5x65 s5s6 L 69 N.s5s6.10
Polar TM5 K 249 5x64 s15s16 S 242 C.s15s16.04
Hydrophobic TM3 I 156 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 I 156 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic TM6 T 302 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 T 302 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 160 34x51 S8 L 126 N.S8.03
Hydrophobic TM5 P 256 5x71 s15s16 L 243 C.s15s16.05
Van-der-waals TM5 P 256 5x71 s15s16 L 243 C.s15s16.05
Hydrophobic TM3 R 152 3x50 s5s6 I 67 N.s5s6.08
Polar ICL2 P 159 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 159 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 159 34x50 S5 Y 59 N.S5.12
Polar ICL2 L 160 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 L 160 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 160 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 L 160 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 160 34x51 S15 V 238 C.S15.14
Hydrophobic ICL2 F 162 34x53 s8s9 P 136 N.s8s9.10
Hydrophobic TM5 I 255 5x70 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 I 255 5x70 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 P 256 5x71 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 P 256 5x71 s15s16 L 240 C.s15s16.02
Ionic ICL1 H 83 12x48 s20c E 383 C.s20c.17
Hydrophobic ICL3 V 261 - S6 K 73 N.S6.03
Hydrophobic TM6 Q 295 6x26 S6 F 71 N.S6.01
Van-der-waals TM6 Q 295 6x26 S6 F 71 N.S6.01
Hydrophobic H8 K 370 8x49 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 P 256 5x71 s15s16 V 239 C.s15s16.01
Van-der-waals TM5 P 256 5x71 s15s16 V 239 C.s15s16.01
Polar TM6 Q 295 6x26 s5s6 T 70 N.s5s6.11
Polar ICL3 S 260 - s17s18 D 308 C.s17s18.37
Van-der-waals ICL3 S 260 - s17s18 D 308 C.s17s18.37
Hydrophobic TM3 A 155 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 L 160 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 L 160 34x51 S16 D 244 C.S16.01
Hydrophobic TM4 T 165 4x38 s8s9 D 132 N.s8s9.06
Van-der-waals TM4 T 165 4x38 s8s9 D 132 N.s8s9.06
Polar ICL3 G 257 - S6 K 73 N.S6.03
Hydrophobic ICL3 G 257 - S6 K 73 N.S6.03
Van-der-waals ICL3 G 257 - S6 K 73 N.S6.03
Hydrophobic TM5 P 256 5x71 s15s16 S 242 C.s15s16.04
Ionic H8 K 370 8x49 s5s6 E 65 N.s5s6.06
Polar H8 K 370 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 K 370 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 K 370 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 F 162 34x53 s8s9 Q 127 N.s8s9.01
Polar TM2 T 89 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 T 89 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 89 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 F 162 34x53 s8s9 P 128 N.s8s9.02
Hydrophobic ICL3 V 262 - s17s18 L 311 C.s17s18.40
Van-der-waals ICL3 V 262 - s17s18 L 311 C.s17s18.40
Hydrophobic TM2 T 87 2x37 s5s6 D 63 N.s5s6.04
Polar TM5 P 256 5x71 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 P 256 5x71 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 P 256 5x71 s15s16 Y 241 C.s15s16.03