Beta-arrestin-1 - OXE receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OXE 66.0
Beta-arrestin-1 80.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 22.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic C-term S 381 - s9s10 H 159 N.s9s10.11
Van-der-waals C-term S 381 - s9s10 H 159 N.s9s10.11
Polar C-term Y 386 - S6 D 78 N.S6.04
Hydrophobic C-term Y 386 - S6 D 78 N.S6.04
Van-der-waals C-term Y 386 - S6 D 78 N.S6.04
Hydrophobic TM3 V 194 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 V 194 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 H 199 34x52 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 H 199 34x52 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 V 200 34x53 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 V 200 34x53 s8s9 T 136 N.s8s9.07
Polar ICL2 R 203 34x56 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 203 34x56 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 R 203 34x56 s8s9 E 134 N.s8s9.05
Hydrophobic TM3 K 193 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 K 193 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic C-term Y 386 - S6 R 76 N.S6.02
Van-der-waals C-term Y 386 - S6 R 76 N.S6.02
Ionic C-term R 393 - s9s10 E 155 N.s9s10.07
Polar C-term R 393 - s9s10 E 155 N.s9s10.07
Van-der-waals C-term R 393 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL3 L 284 - S6 F 75 N.S6.01
Van-der-waals ICL3 L 284 - S6 F 75 N.S6.01
Polar H8 S 359 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic H8 S 359 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 S 359 8x47 s5s6 V 70 N.s5s6.07
Ionic ICL2 R 203 34x56 s8s9 D 135 N.s8s9.06
Polar ICL2 R 203 34x56 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 R 203 34x56 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 203 34x56 s8s9 D 135 N.s8s9.06
Polar TM3 R 190 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 190 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 190 3x50 s5s6 L 71 N.s5s6.08
Polar ICL2 H 198 34x51 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 H 198 34x51 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 H 198 34x51 s15s16 T 246 C.s15s16.05
Polar TM6 G 289 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 G 289 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 G 289 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals TM3 R 190 3x50 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 H 198 34x51 S15 I 241 C.S15.14
Polar TM7 S 358 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 S 358 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 S 358 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 P 290 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM2 N 127 2x39 s5s6 L 71 N.s5s6.08
Polar C-term P 379 - s9s10 H 159 N.s9s10.11
Hydrophobic C-term P 379 - s9s10 H 159 N.s9s10.11
Van-der-waals C-term P 379 - s9s10 H 159 N.s9s10.11
Hydrophobic TM6 Q 287 6x27 S6 F 75 N.S6.01
Van-der-waals TM6 Q 287 6x27 S6 F 75 N.S6.01
Hydrophobic TM2 T 125 2x37 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 T 125 2x37 s5s6 V 70 N.s5s6.07
Polar TM3 K 193 3x53 s8s9 K 138 N.s8s9.09
Polar ICL2 H 198 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 H 198 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 H 198 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 A 293 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic H8 P 360 8x48 s5s6 V 70 N.s5s6.07
Van-der-waals H8 P 360 8x48 s5s6 V 70 N.s5s6.07
Polar ICL3 R 282 - s15s16 F 244 C.s15s16.03
Aromatic ICL3 R 282 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL3 R 282 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 R 282 - s15s16 F 244 C.s15s16.03
Polar ICL2 R 203 34x56 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 R 203 34x56 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 203 34x56 s8s9 T 136 N.s8s9.07
Polar ICL2 P 197 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 197 34x50 S5 Y 63 N.S5.12
Polar C-term D 382 - S10 R 165 N.S10.03
Van-der-waals C-term D 382 - S10 R 165 N.S10.03
Polar C-term Q 377 - s9s10 R 161 N.s9s10.13
Hydrophobic C-term V 380 - s9s10 H 159 N.s9s10.11
Polar ICL2 H 198 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 H 198 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 H 198 34x51 S5 Y 63 N.S5.12
Hydrophobic TM6 R 292 6x32 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 R 292 6x32 s5s6 G 72 N.s5s6.09
Polar C-term Y 386 - S5 T 58 N.S5.07
Hydrophobic C-term Y 386 - S5 T 58 N.S5.07
Van-der-waals C-term Y 386 - S5 T 58 N.S5.07
Hydrophobic C-term P 379 - s9s10 R 161 N.s9s10.13
Van-der-waals C-term P 379 - s9s10 R 161 N.s9s10.13
Hydrophobic TM6 G 289 6x29 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 G 289 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 R 292 6x32 s5s6 L 71 N.s5s6.08
Polar ICL2 H 198 34x51 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 H 198 34x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 H 198 34x51 s8s9 T 136 N.s8s9.07
Hydrophobic C-term W 392 - s9s10 L 154 N.s9s10.03
Van-der-waals C-term W 392 - s9s10 L 154 N.s9s10.03
Hydrophobic TM7 S 358 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 S 358 7x56 s5s6 V 70 N.s5s6.07
Ionic TM6 R 292 6x32 s5s6 D 69 N.s5s6.06
Polar TM6 R 292 6x32 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 K 193 3x53 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 L 284 - s15s16 F 244 C.s15s16.03
Polar C-term S 384 - S10 R 165 N.S10.03
Hydrophobic C-term S 384 - S10 R 165 N.S10.03
Van-der-waals C-term S 384 - S10 R 165 N.S10.03
Ionic C-term E 383 - s9s10 K 157 N.s9s10.09
Polar C-term E 383 - s9s10 K 157 N.s9s10.09
Hydrophobic C-term E 383 - s9s10 K 157 N.s9s10.09
Van-der-waals C-term E 383 - s9s10 K 157 N.s9s10.09
Hydrophobic ICL2 P 197 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 P 197 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic C-term G 378 - s9s10 H 159 N.s9s10.11
Van-der-waals C-term G 378 - s9s10 H 159 N.s9s10.11
Polar TM6 Q 287 6x27 S6 R 76 N.S6.02
Hydrophobic TM6 Q 287 6x27 S6 R 76 N.S6.02
Van-der-waals TM6 Q 287 6x27 S6 R 76 N.S6.02
Ionic C-term D 382 - s9s10 K 160 N.s9s10.12
Polar C-term D 382 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term D 382 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term D 382 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term V 380 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term Y 386 - S6 V 81 N.S6.07
Van-der-waals C-term Y 386 - S6 V 81 N.S6.07
Polar ICL2 H 198 34x51 S16 A 247 C.S16.01
Hydrophobic ICL2 H 198 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 H 198 34x51 S16 A 247 C.S16.01
Polar ICL2 P 197 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 P 197 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 197 34x50 s15s16 N 245 C.s15s16.04