Beta-arrestin-1 - oxoglutarate receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
oxoglutarate 82.6
Beta-arrestin-1 80.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 17.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 242 6x36 s5s6 L 68 N.s5s6.05
Hydrophobic ICL1 R 63 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL1 R 63 - s8s9 E 134 N.s8s9.05
Polar TM3 R 131 3x50 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 R 131 3x50 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 R 131 3x50 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 T 243 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 243 6x37 s5s6 L 71 N.s5s6.08
Polar H8 N 308 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic H8 N 308 8x49 s5s6 D 67 N.s5s6.04
Van-der-waals H8 N 308 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 L 225 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 225 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM7 Y 302 7x53 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 F 142 34x54 s15s16 C 242 C.s15s16.01
Van-der-waals ICL2 F 142 34x54 s15s16 C 242 C.s15s16.01
Hydrophobic TM6 L 235 6x29 s20c E 405 C.s20c.15
Hydrophobic TM6 L 246 6x40 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 F 142 34x54 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 F 142 34x54 s15s16 T 246 C.s15s16.05
Hydrophobic TM6 L 235 6x29 s5s6 L 73 N.s5s6.10
Polar TM2 K 66 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic TM2 K 66 2x37 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 K 66 2x37 s8s9 T 136 N.s8s9.07
Ionic TM2 K 66 2x37 s5s6 D 67 N.s5s6.04
Polar TM2 K 66 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 K 66 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 I 221 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 M 139 34x51 S6 K 77 N.S6.03
Hydrophobic ICL2 H 145 34x57 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 H 145 34x57 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 V 134 3x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 V 134 3x53 s5s6 V 70 N.s5s6.07
Polar TM2 S 68 2x39 s5s6 D 69 N.s5s6.06
Hydrophobic TM2 S 68 2x39 s5s6 D 69 N.s5s6.06
Van-der-waals TM2 S 68 2x39 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 R 131 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 131 3x50 s5s6 L 71 N.s5s6.08
Polar H8 S 306 8x47 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 F 142 34x54 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 F 142 34x54 s15s16 N 245 C.s15s16.04
Polar ICL1 P 64 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL1 P 64 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL1 P 64 - s8s9 E 134 N.s8s9.05
Hydrophobic TM6 A 239 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 239 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 131 3x50 s5s6 D 69 N.s5s6.06
Hydrophobic H8 S 306 8x47 s5s6 L 68 N.s5s6.05
Van-der-waals H8 S 306 8x47 s5s6 L 68 N.s5s6.05
Hydrophobic ICL1 W 65 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 W 65 - s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 M 139 34x51 s15s16 L 243 C.s15s16.02
Van-der-waals ICL2 M 139 34x51 s15s16 L 243 C.s15s16.02
Hydrophobic TM7 V 305 7x56 s5s6 L 68 N.s5s6.05
Van-der-waals TM7 V 305 7x56 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 P 138 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 P 138 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 P 138 34x50 S6 F 75 N.S6.01
Van-der-waals ICL2 P 138 34x50 S6 F 75 N.S6.01
Hydrophobic TM6 K 236 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 F 130 3x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 D 307 8x48 s5s6 E 66 N.s5s6.03
Van-der-waals H8 D 307 8x48 s5s6 E 66 N.s5s6.03
Polar ICL2 F 142 34x54 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 F 142 34x54 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 F 142 34x54 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 V 134 3x53 S6 F 75 N.S6.01
Van-der-waals TM3 V 134 3x53 S6 F 75 N.S6.01
Hydrophobic ICL1 P 64 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 P 64 - s8s9 T 136 N.s8s9.07
Hydrophobic TM6 A 239 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 239 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 135 3x54 S6 F 75 N.S6.01
Ionic TM6 D 232 6x26 s9s10 K 157 N.s9s10.09
Polar TM6 D 232 6x26 s9s10 K 157 N.s9s10.09
Van-der-waals TM6 D 232 6x26 s9s10 K 157 N.s9s10.09
Hydrophobic TM6 L 242 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 135 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL1 P 64 - s8s9 D 135 N.s8s9.06
Hydrophobic TM3 I 135 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 135 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 F 142 34x54 s15s16 L 243 C.s15s16.02
Hydrophobic TM3 I 135 3x54 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 M 139 34x51 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 M 139 34x51 s15s16 F 244 C.s15s16.03