Arrestin-C - oxoglutarate receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
oxoglutarate 81.8
Arrestin-C 81.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 139 34x51 S6 K 73 N.S6.03
Van-der-waals ICL2 M 139 34x51 S6 K 73 N.S6.03
Hydrophobic TM3 I 135 3x54 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 V 134 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 V 134 3x53 S6 F 71 N.S6.01
Hydrophobic ICL2 M 139 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 M 139 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 F 142 34x54 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 F 142 34x54 s15s16 S 242 C.s15s16.04
Hydrophobic TM2 M 72 2x43 s5s6 L 64 N.s5s6.05
Polar H8 N 308 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 N 308 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic TM7 V 305 7x56 s5s6 I 67 N.s5s6.08
Hydrophobic TM1 Y 58 1x57 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 P 138 34x50 S6 F 71 N.S6.01
Van-der-waals ICL2 P 138 34x50 S6 F 71 N.S6.01
Hydrophobic TM6 L 235 6x29 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 F 142 34x54 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 F 142 34x54 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 L 225 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 225 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic H8 S 306 8x47 s5s6 L 64 N.s5s6.05
Van-der-waals H8 S 306 8x47 s5s6 L 64 N.s5s6.05
Polar TM3 R 131 3x50 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 R 131 3x50 s5s6 E 65 N.s5s6.06
Van-der-waals TM3 R 131 3x50 s5s6 E 65 N.s5s6.06
Aromatic ICL2 F 142 34x54 s5s6 R 61 N.s5s6.02
Ionic ICL2 H 145 34x57 s5s6 E 65 N.s5s6.06
Polar ICL2 H 145 34x57 s5s6 E 65 N.s5s6.06
Polar TM2 K 66 2x37 s5s6 D 62 N.s5s6.03
Hydrophobic TM6 L 242 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 242 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 F 127 3x46 s5s6 E 65 N.s5s6.06
Polar TM2 S 68 2x39 s5s6 E 65 N.s5s6.06
Hydrophobic TM2 S 68 2x39 s5s6 E 65 N.s5s6.06
Van-der-waals TM2 S 68 2x39 s5s6 E 65 N.s5s6.06
Hydrophobic TM6 A 239 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 239 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 L 235 6x29 s5s6 L 69 N.s5s6.10
Polar ICL3 Q 230 - S10 Y 160 N.S10.01
Hydrophobic TM6 A 239 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 A 239 6x33 s5s6 I 67 N.s5s6.08
Aromatic ICL2 F 142 34x54 S5 Y 59 N.S5.12
Hydrophobic ICL2 F 142 34x54 S5 Y 59 N.S5.12
Van-der-waals ICL2 F 142 34x54 S5 Y 59 N.S5.12
Ionic TM2 K 66 2x37 s5s6 D 63 N.s5s6.04
Polar TM2 K 66 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 K 66 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 K 66 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 V 134 3x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 V 134 3x53 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 K 236 6x30 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 K 236 6x30 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 F 130 3x49 s5s6 E 65 N.s5s6.06
Van-der-waals TM3 F 130 3x49 s5s6 E 65 N.s5s6.06
Hydrophobic TM6 K 238 6x32 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 S 68 2x39 s5s6 L 64 N.s5s6.05
Hydrophobic TM7 V 305 7x56 s5s6 L 64 N.s5s6.05
Van-der-waals TM7 V 305 7x56 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 I 135 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 135 3x54 S6 F 71 N.S6.01
Hydrophobic TM3 V 134 3x53 s5s6 E 65 N.s5s6.06
Van-der-waals TM3 V 134 3x53 s5s6 E 65 N.s5s6.06
Polar ICL2 H 145 34x57 s5s6 R 61 N.s5s6.02
Aromatic ICL2 H 145 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 H 145 34x57 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 H 145 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic ICL1 P 64 - s8s9 A 133 N.s8s9.07
Hydrophobic TM3 V 134 3x53 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 V 134 3x53 s5s6 R 61 N.s5s6.02