Beta-arrestin-1 - OT receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OT 75.9
Beta-arrestin-1 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 145 - S5 Y 63 N.S5.12
Hydrophobic ICL2 P 144 - S6 F 75 N.S6.01
Polar TM4 R 150 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM4 R 150 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM6 A 269 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 A 269 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic TM2 R 73 2x38 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 R 73 2x38 s5s6 R 65 N.s5s6.02
Polar ICL2 L 145 - S16 Y 249 C.S16.03
Hydrophobic ICL3 L 257 - S6 F 80 N.S6.06
Van-der-waals ICL3 L 257 - S6 F 80 N.S6.06
Hydrophobic ICL3 R 259 - S6 D 78 N.S6.04
Polar TM2 R 73 2x38 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 R 73 2x38 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 R 73 2x38 s5s6 D 67 N.s5s6.04
Hydrophobic ICL3 L 257 - s7s8 P 120 N.s7s8.03
Ionic TM3 D 136 3x49 s5s6 R 65 N.s5s6.02
Polar TM3 D 136 3x49 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 D 136 3x49 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 D 136 3x49 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 M 276 6x36 s5s6 V 70 N.s5s6.07
Ionic TM6 K 264 6x24 s9s10 E 155 N.s9s10.07
Polar TM6 K 264 6x24 s9s10 E 155 N.s9s10.07
Van-der-waals TM6 K 264 6x24 s9s10 E 155 N.s9s10.07
Hydrophobic ICL3 V 260 - S6 D 78 N.S6.04
Van-der-waals ICL3 V 260 - S6 D 78 N.S6.04
Polar ICL1 Q 69 12x49 s20c E 405 C.s20c.15
Hydrophobic ICL1 Q 69 12x49 s20c E 405 C.s20c.15
Van-der-waals ICL1 Q 69 12x49 s20c E 405 C.s20c.15
Hydrophobic TM3 R 137 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 M 276 6x36 s5s6 L 71 N.s5s6.08
Polar ICL3 S 261 - S6 D 78 N.S6.04
Van-der-waals ICL3 S 261 - S6 D 78 N.S6.04
Hydrophobic ICL3 R 259 - S6 V 81 N.S6.07
Hydrophobic ICL2 L 145 - S15 I 241 C.S15.14
Hydrophobic ICL1 R 68 12x48 s20c E 405 C.s20c.15
Van-der-waals ICL1 R 68 12x48 s20c E 405 C.s20c.15
Hydrophobic TM6 R 272 6x32 s5s6 L 71 N.s5s6.08
Polar TM6 R 272 6x32 s5s6 D 69 N.s5s6.06
Polar ICL2 P 144 - s5s6 G 64 N.s5s6.01
Hydrophobic ICL2 P 144 - s5s6 G 64 N.s5s6.01
Van-der-waals ICL2 P 144 - s5s6 G 64 N.s5s6.01
Hydrophobic ICL2 L 145 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 145 - s15s16 N 245 C.s15s16.04
Polar TM5 K 234 5x72 S6 R 76 N.S6.02
Hydrophobic TM3 A 140 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM7 F 332 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic H8 T 333 8x47 s5s6 V 70 N.s5s6.07
Polar TM6 T 273 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 273 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 273 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 A 140 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 A 140 3x53 s5s6 R 65 N.s5s6.02
Ionic TM4 R 151 4x40 s8s9 E 134 N.s8s9.05
Polar TM4 R 151 4x40 s8s9 E 134 N.s8s9.05
Hydrophobic TM4 R 151 4x40 s8s9 E 134 N.s8s9.05
Hydrophobic TM5 I 223 5x61 s5s6 L 71 N.s5s6.08
Polar TM6 R 272 6x32 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 R 272 6x32 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 S 72 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 S 72 2x37 s5s6 D 67 N.s5s6.04
Polar ICL1 K 70 12x50 s20c E 405 C.s20c.15
Hydrophobic TM2 L 74 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 L 74 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 P 144 - S5 Y 63 N.S5.12
Van-der-waals ICL2 P 144 - S5 Y 63 N.S5.12
Van-der-waals ICL2 L 148 - s8s9 D 135 N.s8s9.06
Ionic ICL1 K 70 12x50 s20c D 402 C.s20c.12
Polar ICL1 K 70 12x50 s20c D 402 C.s20c.12
Hydrophobic ICL1 K 70 12x50 s20c D 402 C.s20c.12
Hydrophobic TM3 I 141 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 A 269 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 I 227 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 I 227 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 141 3x54 S6 F 75 N.S6.01
Hydrophobic ICL2 L 145 - S9 C 140 N.S9.01
Polar TM2 L 74 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 L 74 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 I 141 3x54 s5s6 L 68 N.s5s6.05
Polar ICL3 L 257 - S6 V 81 N.S6.07
Van-der-waals ICL3 L 257 - S6 V 81 N.S6.07
Hydrophobic TM6 R 272 6x32 s5s6 G 72 N.s5s6.09
Hydrophobic TM3 I 141 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 141 3x54 s5s6 L 71 N.s5s6.08