Arrestin-C - OT receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
OT 73.0
Arrestin-C 79.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM6 K 264 6x24 s9s10 E 152 N.s9s10.07
Polar TM6 K 264 6x24 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 K 264 6x24 s9s10 E 152 N.s9s10.07
Van-der-waals TM6 K 264 6x24 s9s10 E 152 N.s9s10.07
Hydrophobic TM3 I 141 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 141 3x54 s5s6 I 67 N.s5s6.08
Polar ICL2 L 145 - S16 D 244 C.S16.01
Hydrophobic ICL2 L 145 - S16 D 244 C.S16.01
Van-der-waals ICL2 L 145 - S16 D 244 C.S16.01
Hydrophobic TM3 Q 143 3x56 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 Q 143 3x56 s15s16 S 242 C.s15s16.04
Hydrophobic ICL3 A 258 - S6 V 77 N.S6.07
Van-der-waals ICL3 A 258 - S6 V 77 N.S6.07
Hydrophobic TM2 L 74 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 L 74 2x39 s5s6 V 66 N.s5s6.07
Polar TM5 K 234 5x72 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 T 273 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 T 273 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 R 272 6x32 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 L 145 - S8 L 126 N.S8.03
Van-der-waals ICL2 L 145 - S8 L 126 N.S8.03
Hydrophobic ICL2 L 148 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 L 148 - s5s6 R 61 N.s5s6.02
Hydrophobic TM5 I 227 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 I 227 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic ICL3 V 260 - S6 V 77 N.S6.07
Van-der-waals ICL3 V 260 - S6 V 77 N.S6.07
Polar ICL2 P 144 - S5 Y 59 N.S5.12
Hydrophobic ICL2 P 144 - S5 Y 59 N.S5.12
Van-der-waals ICL2 P 144 - S5 Y 59 N.S5.12
Hydrophobic ICL3 V 260 - S6 D 74 N.S6.04
Van-der-waals ICL3 V 260 - S6 D 74 N.S6.04
Hydrophobic TM3 I 141 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 141 3x54 S6 F 71 N.S6.01
Polar TM5 N 230 5x68 S6 K 73 N.S6.03
Hydrophobic TM5 N 230 5x68 S6 K 73 N.S6.03
Polar TM5 N 230 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 N 230 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 N 230 5x68 s15s16 Y 241 C.s15s16.03
Polar TM3 R 137 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 137 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 137 3x50 s5s6 V 66 N.s5s6.07
Polar ICL2 L 145 - S5 Y 59 N.S5.12
Hydrophobic ICL2 L 145 - S5 Y 59 N.S5.12
Van-der-waals ICL2 L 145 - S5 Y 59 N.S5.12
Polar TM6 R 272 6x32 s5s6 I 67 N.s5s6.08
Polar ICL2 R 146 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 R 146 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 R 146 - s5s6 R 61 N.s5s6.02
Polar TM4 R 150 4x39 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 R 150 4x39 s8s9 E 131 N.s8s9.05
Hydrophobic TM3 A 140 3x53 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 A 140 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 A 140 3x53 s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 S 262 - S6 D 74 N.S6.04
Van-der-waals ICL3 S 262 - S6 D 74 N.S6.04
Hydrophobic TM3 A 140 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 R 137 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 137 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 I 227 5x65 S6 F 71 N.S6.01
Hydrophobic ICL2 L 145 - S9 C 137 N.S9.01
Van-der-waals ICL2 L 145 - S9 C 137 N.S9.01
Polar ICL2 P 144 - s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 P 144 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 144 - s15s16 S 242 C.s15s16.04
Polar ICL2 P 144 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 P 144 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 P 144 - s5s6 R 61 N.s5s6.02
Hydrophobic TM6 A 269 6x29 s5s6 L 69 N.s5s6.10
Hydrophobic ICL3 A 258 - S6 Q 78 N.S6.08
Hydrophobic ICL3 V 260 - S6 Y 76 N.S6.06
Hydrophobic TM5 A 237 5x75 s17s18 L 311 C.s17s18.40
Hydrophobic TM2 L 74 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 P 144 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 144 - s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 L 233 5x71 s17s18 E 310 C.s17s18.39
Van-der-waals ICL3 L 257 - s6h1 E 86 N.s6h1.03
Hydrophobic ICL3 A 258 - S6 Y 76 N.S6.06
Polar ICL2 L 145 - S16 Y 246 C.S16.03
Hydrophobic ICL2 L 145 - S16 Y 246 C.S16.03
Van-der-waals ICL2 L 145 - S16 Y 246 C.S16.03
Hydrophobic TM4 R 149 4x38 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 R 149 4x38 s8s9 E 131 N.s8s9.05
Hydrophobic TM6 T 273 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 T 273 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 N 230 5x68 s15s16 L 240 C.s15s16.02
Van-der-waals ICL2 L 148 - s8s9 D 132 N.s8s9.06
Hydrophobic ICL3 L 257 - S6 Q 78 N.S6.08
Polar ICL2 R 146 - S16 D 244 C.S16.01
Hydrophobic ICL2 R 146 - S16 D 244 C.S16.01
Van-der-waals ICL2 R 146 - S16 D 244 C.S16.01
Hydrophobic TM3 I 141 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 145 - S15 V 238 C.S15.14
Van-der-waals ICL2 L 145 - S15 V 238 C.S15.14
Polar TM3 Q 143 3x56 s5s6 R 61 N.s5s6.02
Van-der-waals TM3 Q 143 3x56 s5s6 R 61 N.s5s6.02
Ionic TM2 R 73 2x38 s5s6 D 63 N.s5s6.04
Polar TM2 R 73 2x38 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 R 73 2x38 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 M 276 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 C 142 3x55 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 I 141 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 I 141 3x54 s5s6 L 64 N.s5s6.05
Polar ICL2 L 145 - s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 145 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 L 145 - s15s16 S 242 C.s15s16.04
Hydrophobic H8 T 333 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 T 333 8x47 s5s6 V 66 N.s5s6.07
Polar ICL3 L 257 - S6 T 79 N.S6.09
Hydrophobic ICL3 L 257 - S6 T 79 N.S6.09
Van-der-waals ICL3 L 257 - S6 T 79 N.S6.09
Hydrophobic TM5 K 234 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 K 234 5x72 S6 K 73 N.S6.03
Polar ICL2 L 145 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 L 145 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 L 145 - s5s6 R 61 N.s5s6.02
Hydrophobic TM2 S 72 2x37 s5s6 D 62 N.s5s6.03
Van-der-waals TM2 S 72 2x37 s5s6 D 62 N.s5s6.03