S-arrestin - P2Y1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2Y1 76.7
S-arrestin 79.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 M 90 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 I 86 2x39 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 I 86 2x39 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 L 157 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 L 157 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic TM6 L 254 6x30 S6 F 83 N.S6.01
Van-der-waals TM6 L 254 6x30 S6 F 83 N.S6.01
Hydrophobic ICL2 L 160 34x54 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 160 34x54 S16 Y 259 C.S16.03
Hydrophobic TM2 S 84 2x37 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 S 84 2x37 s5s6 V 78 N.s5s6.07
Polar ICL2 K 158 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 K 158 34x52 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 K 158 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic H8 T 330 8x49 s5s6 D 75 N.s5s6.04
Polar TM6 K 257 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 K 257 6x33 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 K 257 6x33 s5s6 G 80 N.s5s6.09
Polar ICL2 S 159 34x53 S5 Y 71 N.S5.12
Hydrophobic TM3 G 152 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 G 152 3x53 S6 F 83 N.S6.01
Polar H8 D 329 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 D 329 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 V 153 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 153 3x54 S6 F 83 N.S6.01
Polar H8 T 330 8x49 s5s6 V 78 N.s5s6.07
Van-der-waals H8 T 330 8x49 s5s6 V 78 N.s5s6.07
Polar H8 T 330 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 T 330 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 T 330 8x49 s5s6 D 77 N.s5s6.06
Ionic TM6 K 257 6x33 s5s6 D 77 N.s5s6.06
Polar TM6 K 257 6x33 s5s6 D 77 N.s5s6.06
Van-der-waals TM6 K 257 6x33 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 R 149 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 149 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 L 157 34x51 s15s16 V 252 C.s15s16.01
Ionic H8 R 334 8x53 s5s6 D 75 N.s5s6.04
Polar H8 R 334 8x53 s5s6 D 75 N.s5s6.04
Van-der-waals H8 R 334 8x53 s5s6 D 75 N.s5s6.04
Hydrophobic H8 R 337 8x56 s20c R 398 C.s20c.17
Van-der-waals H8 R 337 8x56 s20c R 398 C.s20c.17
Polar ICL2 P 156 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 P 156 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 156 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic TM7 A 327 7x56 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 A 327 7x56 s5s6 V 78 N.s5s6.07
Polar ICL2 P 156 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 156 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 156 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 157 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 L 261 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 L 157 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 157 34x51 S15 V 251 C.S15.14
Hydrophobic ICL2 L 157 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 L 157 34x51 S16 D 257 C.S16.01
Hydrophobic ICL3 L 249 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL3 L 249 - s15s16 Y 254 C.s15s16.03
Ionic TM4 K 164 4x38 s8s9 D 142 N.s8s9.06
Polar TM4 K 164 4x38 s8s9 D 142 N.s8s9.06
Hydrophobic TM4 K 164 4x38 s8s9 D 142 N.s8s9.06
Van-der-waals TM4 K 164 4x38 s8s9 D 142 N.s8s9.06
Polar TM7 A 327 7x56 s5s6 I 79 N.s5s6.08
Hydrophobic TM7 A 327 7x56 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 A 327 7x56 s5s6 I 79 N.s5s6.08
Polar ICL2 L 160 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 L 160 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 L 160 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM6 L 254 6x30 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 L 254 6x30 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 L 254 6x30 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 L 254 6x30 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 K 247 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM2 I 86 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 I 86 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 V 153 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM2 M 90 2x43 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 M 90 2x43 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 I 145 3x46 s5s6 I 79 N.s5s6.08
Polar ICL2 L 160 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 160 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 160 34x54 S5 Y 71 N.S5.12
Hydrophobic ICL2 G 161 34x55 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 G 161 34x55 s8s9 K 145 N.s8s9.09
Polar TM7 A 327 7x56 s5s6 G 80 N.s5s6.09
Van-der-waals TM7 A 327 7x56 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 K 257 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 K 257 6x33 s5s6 I 79 N.s5s6.08
Ionic C-term R 344 - s20c E 405 C.s20c.24
Polar C-term R 344 - s20c E 405 C.s20c.24
Hydrophobic C-term R 344 - s20c E 405 C.s20c.24
Van-der-waals C-term R 344 - s20c E 405 C.s20c.24
Hydrophobic ICL2 P 156 34x50 S6 F 83 N.S6.01
Hydrophobic ICL2 L 157 34x51 S5 F 69 N.S5.10
Hydrophobic ICL2 L 157 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 157 34x51 S5 Y 71 N.S5.12
Polar H8 G 328 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 G 328 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 G 328 8x47 s5s6 V 78 N.s5s6.07
Ionic H8 R 333 8x52 s5s6 D 77 N.s5s6.06
Polar H8 R 333 8x52 s5s6 D 77 N.s5s6.06
Polar ICL2 K 158 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 K 158 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 K 158 34x52 S16 D 257 C.S16.01
Van-der-waals TM6 S 258 6x34 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 R 149 3x50 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 R 149 3x50 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 L 157 34x51 s15s16 L 253 C.s15s16.02
Van-der-waals ICL2 L 157 34x51 s15s16 L 253 C.s15s16.02