Beta-arrestin-1 - P2Y2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2Y2 73.4
Beta-arrestin-1 79.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 131 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 131 3x50 s5s6 V 70 N.s5s6.07
Polar ICL2 S 141 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 S 141 34x53 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 S 141 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 L 142 34x54 S16 A 247 C.S16.01
Hydrophobic TM6 I 247 6x38 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 247 6x38 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 131 3x50 s5s6 L 68 N.s5s6.05
Polar TM6 S 243 6x34 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 S 243 6x34 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 S 243 6x34 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 225 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 225 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM7 Y 306 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 306 7x53 s5s6 V 70 N.s5s6.07
Polar ICL2 P 138 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 138 34x50 s15s16 N 245 C.s15s16.04
Polar ICL2 G 145 34x57 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 G 145 34x57 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 G 145 34x57 s8s9 T 136 N.s8s9.07
Hydrophobic TM7 L 305 7x52 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 L 305 7x52 s5s6 V 70 N.s5s6.07
Polar ICL2 L 139 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 139 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 139 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 142 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 L 142 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic TM6 T 246 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 S 243 6x34 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 S 243 6x34 s5s6 L 73 N.s5s6.10
Hydrophobic H8 G 310 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 N 66 2x37 s8s9 T 136 N.s8s9.07
Polar TM2 N 66 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 N 66 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 N 66 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 M 221 5x61 s5s6 L 71 N.s5s6.08
Polar ICL2 P 138 34x50 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 P 138 34x50 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 P 138 34x50 s5s6 R 65 N.s5s6.02
Hydrophobic H8 Q 311 8x48 s5s6 G 72 N.s5s6.09
Van-der-waals H8 Q 311 8x48 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 L 142 34x54 S15 I 241 C.S15.14
Polar H8 R 312 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 R 312 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 R 312 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 R 131 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 142 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 142 34x54 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 142 34x54 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 142 34x54 s15s16 N 245 C.s15s16.04
Polar ICL2 L 139 34x51 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 L 139 34x51 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 L 142 34x54 s5s6 R 65 N.s5s6.02
Polar ICL1 T 64 - s8s9 P 133 N.s8s9.04
Hydrophobic ICL1 T 64 - s8s9 P 133 N.s8s9.04
Van-der-waals ICL1 T 64 - s8s9 P 133 N.s8s9.04
Polar ICL2 R 143 34x55 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 R 143 34x55 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 R 143 34x55 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 L 139 34x51 s15s16 L 243 C.s15s16.02
Hydrophobic ICL2 P 138 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 P 138 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 P 138 34x50 S6 F 75 N.S6.01
Polar H8 Q 311 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 Q 311 8x48 s5s6 D 69 N.s5s6.06
Polar H8 Q 311 8x48 s20c E 405 C.s20c.15
Van-der-waals H8 Q 311 8x48 s20c E 405 C.s20c.15
Hydrophobic H8 G 310 8x47 s5s6 D 69 N.s5s6.06
Polar ICL2 L 142 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 L 142 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 L 142 34x54 s8s9 T 136 N.s8s9.07
Polar TM6 T 246 6x37 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 T 246 6x37 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 T 246 6x37 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 G 134 3x53 s5s6 L 68 N.s5s6.05
Ionic H8 R 315 8x52 s20c E 405 C.s20c.15
Polar H8 R 315 8x52 s20c E 405 C.s20c.15
Hydrophobic H8 R 315 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 R 315 8x52 s20c E 405 C.s20c.15
Hydrophobic TM3 V 135 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 V 135 3x54 S6 F 75 N.S6.01
Ionic TM3 H 130 3x49 s5s6 D 67 N.s5s6.04
Polar TM3 H 130 3x49 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 H 130 3x49 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 H 130 3x49 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 V 135 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 V 135 3x54 s5s6 L 71 N.s5s6.08
Polar TM4 R 146 4x38 s8s9 T 136 N.s8s9.07
Hydrophobic TM4 R 146 4x38 s8s9 T 136 N.s8s9.07
Van-der-waals TM4 R 146 4x38 s8s9 T 136 N.s8s9.07
Polar TM3 G 134 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 G 134 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 G 134 3x53 s5s6 R 65 N.s5s6.02
Ionic H8 R 312 8x49 s5s6 E 66 N.s5s6.03
Polar H8 R 312 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 R 312 8x49 s5s6 E 66 N.s5s6.03
Van-der-waals H8 R 312 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic TM3 V 135 3x54 s5s6 L 68 N.s5s6.05
Polar TM6 S 233 6x24 s9s10 E 155 N.s9s10.07
Hydrophobic TM6 S 233 6x24 s9s10 E 155 N.s9s10.07
Van-der-waals TM6 S 233 6x24 s9s10 E 155 N.s9s10.07
Polar ICL2 L 139 34x51 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 L 139 34x51 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 L 139 34x51 s15s16 F 244 C.s15s16.03