Arrestin-C - P2Y2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2Y2 70.7
Arrestin-C 78.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 22.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 K 242 6x33 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 K 242 6x33 s5s6 G 68 N.s5s6.09
Hydrophobic TM3 G 134 3x53 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 142 34x54 s5s6 G 60 N.s5s6.01
Hydrophobic ICL2 L 139 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 139 34x51 S15 V 238 C.S15.14
Hydrophobic ICL2 P 138 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 139 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 139 34x51 S16 Y 246 C.S16.03
Hydrophobic TM7 A 309 7x56 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 A 309 7x56 s5s6 I 67 N.s5s6.08
Polar TM2 N 66 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 N 66 2x37 s5s6 D 63 N.s5s6.04
Polar ICL2 L 139 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 L 139 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 139 34x51 S5 Y 59 N.S5.12
Hydrophobic TM5 A 229 5x69 S6 K 73 N.S6.03
Polar ICL3 Y 230 - s17s18 D 308 C.s17s18.37
Hydrophobic ICL3 Y 230 - s17s18 D 308 C.s17s18.37
Van-der-waals ICL3 Y 230 - s17s18 D 308 C.s17s18.37
Hydrophobic H8 R 312 8x49 s5s6 V 66 N.s5s6.07
Van-der-waals H8 R 312 8x49 s5s6 V 66 N.s5s6.07
Polar TM4 R 146 4x38 s8s9 P 130 N.s8s9.04
Van-der-waals TM4 R 146 4x38 s8s9 P 130 N.s8s9.04
Hydrophobic TM4 R 146 4x38 s8s9 A 133 N.s8s9.07
Van-der-waals TM4 R 146 4x38 s8s9 A 133 N.s8s9.07
Hydrophobic TM3 G 134 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 G 134 3x53 S6 F 71 N.S6.01
Polar ICL2 P 138 34x50 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 P 138 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 138 34x50 s15s16 Y 241 C.s15s16.03
Hydrophobic TM2 N 66 2x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 N 66 2x37 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 S 68 2x39 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 S 68 2x39 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 L 142 34x54 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 142 34x54 S5 Y 59 N.S5.12
Polar ICL2 R 143 34x55 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 R 143 34x55 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 R 143 34x55 s8s9 A 133 N.s8s9.07
Polar ICL2 L 139 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 139 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 L 139 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals TM2 N 66 2x37 s5s6 V 66 N.s5s6.07
Ionic TM5 R 224 5x64 s17s18 E 310 C.s17s18.39
Polar TM5 R 224 5x64 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 R 224 5x64 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 R 224 5x64 s17s18 E 310 C.s17s18.39
Hydrophobic TM6 A 239 6x30 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 A 239 6x30 s5s6 T 70 N.s5s6.11
Hydrophobic TM3 V 135 3x54 S6 F 71 N.S6.01
Hydrophobic TM3 V 135 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 V 135 3x54 s5s6 L 69 N.s5s6.10
Polar ICL2 G 145 34x57 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 G 145 34x57 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 G 145 34x57 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 L 142 34x54 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 L 142 34x54 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 L 142 34x54 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 L 142 34x54 s8s9 K 135 N.s8s9.09
Ionic ICL2 R 143 34x55 S16 D 244 C.S16.01
Polar ICL2 R 143 34x55 S16 D 244 C.S16.01
Hydrophobic ICL2 R 143 34x55 S16 D 244 C.S16.01
Van-der-waals ICL2 R 143 34x55 S16 D 244 C.S16.01
Polar TM3 R 131 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 R 131 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 131 3x50 s5s6 I 67 N.s5s6.08
Polar H8 R 312 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic H8 R 312 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 R 312 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic ICL3 T 232 - S6 V 77 N.S6.07
Hydrophobic TM3 R 131 3x50 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 139 34x51 s15s16 L 243 C.s15s16.05
Polar H8 G 310 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic H8 G 310 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 G 310 8x47 s5s6 V 66 N.s5s6.07
Polar ICL1 T 64 - s5s6 D 63 N.s5s6.04
Ionic H8 R 312 8x49 s5s6 D 63 N.s5s6.04
Polar H8 R 312 8x49 s5s6 D 63 N.s5s6.04
Hydrophobic H8 R 312 8x49 s5s6 D 63 N.s5s6.04
Van-der-waals H8 R 312 8x49 s5s6 D 63 N.s5s6.04
Van-der-waals TM7 A 309 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 L 142 34x54 s8s9 G 134 N.s8s9.08
Polar TM7 A 309 7x56 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 L 139 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 L 139 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 L 142 34x54 s5s6 L 64 N.s5s6.05
Van-der-waals ICL2 L 142 34x54 s5s6 L 64 N.s5s6.05
Ionic TM6 R 241 6x32 s9s10 E 152 N.s9s10.07
Polar TM3 R 131 3x50 s5s6 G 68 N.s5s6.09
Polar TM4 R 146 4x38 s8s9 E 131 N.s8s9.05
Hydrophobic ICL3 Y 230 - s17s18 L 311 C.s17s18.40
Van-der-waals ICL3 Y 230 - s17s18 L 311 C.s17s18.40
Hydrophobic ICL2 P 138 34x50 S6 F 71 N.S6.01
Polar TM6 S 243 6x34 s5s6 G 68 N.s5s6.09
Polar ICL2 P 138 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 138 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 138 34x50 S5 Y 59 N.S5.12
Van-der-waals H8 Q 311 8x48 s5s6 E 65 N.s5s6.06
Polar TM6 K 242 6x33 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 K 242 6x33 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 H 130 3x49 s5s6 L 64 N.s5s6.05
Polar TM4 R 146 4x38 s8s9 D 132 N.s8s9.06
Hydrophobic TM4 R 146 4x38 s8s9 D 132 N.s8s9.06
Van-der-waals TM4 R 146 4x38 s8s9 D 132 N.s8s9.06
Hydrophobic TM3 H 130 3x49 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 H 130 3x49 s5s6 I 67 N.s5s6.08
Polar TM6 K 242 6x33 s5s6 E 65 N.s5s6.06
Van-der-waals TM6 K 242 6x33 s5s6 E 65 N.s5s6.06
Ionic ICL1 K 63 - s20c E 383 C.s20c.17
Polar ICL1 K 63 - s20c E 383 C.s20c.17
Van-der-waals ICL1 K 63 - s20c E 383 C.s20c.17
Polar H8 Q 311 8x48 s5s6 V 66 N.s5s6.07
Van-der-waals H8 Q 311 8x48 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 K 242 6x33 s5s6 I 67 N.s5s6.08