Beta-arrestin-1 - P2Y4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2Y4 75.9
Beta-arrestin-1 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM4 R 150 4x40 s8s9 E 134 N.s8s9.05
Polar TM4 R 150 4x40 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 R 150 4x40 s8s9 E 134 N.s8s9.05
Polar ICL2 R 145 34x55 S16 Q 248 C.S16.02
Van-der-waals ICL2 R 145 34x55 S16 Q 248 C.S16.02
Hydrophobic TM6 I 247 6x38 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 247 6x38 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 L 231 - S6 F 75 N.S6.01
Hydrophobic TM3 R 133 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 133 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic ICL3 L 231 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 L 231 - s15s16 F 244 C.s15s16.03
Polar TM6 S 243 6x34 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 S 243 6x34 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 S 243 6x34 s5s6 L 71 N.s5s6.08
Aromatic ICL2 R 145 34x55 S16 Y 249 C.S16.03
Polar TM3 H 139 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 H 139 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 H 139 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 T 246 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 246 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 S 243 6x34 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 S 243 6x34 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 137 3x54 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 I 137 3x54 s5s6 V 70 N.s5s6.07
Polar ICL2 L 144 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 L 144 34x54 s5s6 R 65 N.s5s6.02
Ionic H8 R 315 8x52 s20c E 407 C.s20c.17
Polar H8 R 315 8x52 s20c E 407 C.s20c.17
Hydrophobic H8 R 315 8x52 s20c E 407 C.s20c.17
Van-der-waals H8 R 315 8x52 s20c E 407 C.s20c.17
Hydrophobic TM3 G 136 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 G 136 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 A 235 6x26 s5s6 L 73 N.s5s6.10
Hydrophobic ICL1 P 66 - s8s9 T 136 N.s8s9.07
Hydrophobic TM6 R 240 6x31 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 L 141 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 L 141 34x51 S16 A 247 C.S16.01
Polar TM3 R 133 3x50 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 P 140 34x50 s15s16 N 245 C.s15s16.04
Polar ICL2 P 140 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 140 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 140 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL3 G 233 - S6 K 77 N.S6.03
Polar ICL2 L 141 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 141 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 141 34x51 S5 Y 63 N.S5.12
Polar TM6 S 234 6x25 S6 R 76 N.S6.02
Hydrophobic TM6 S 234 6x25 S6 R 76 N.S6.02
Van-der-waals TM6 S 234 6x25 S6 R 76 N.S6.02
Polar H8 K 312 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic ICL3 G 233 - S6 R 76 N.S6.02
Hydrophobic ICL3 P 232 - S6 K 77 N.S6.03
Van-der-waals ICL3 P 232 - S6 K 77 N.S6.03
Hydrophobic ICL2 L 141 34x51 S9 C 140 N.S9.01
Hydrophobic TM7 T 309 7x56 s5s6 D 69 N.s5s6.06
Van-der-waals TM7 T 309 7x56 s5s6 D 69 N.s5s6.06
Polar H8 D 311 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 D 311 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 D 311 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 H 132 3x49 s5s6 L 68 N.s5s6.05
Hydrophobic H8 G 310 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 G 310 8x47 s5s6 D 69 N.s5s6.06
Polar ICL3 G 233 - S6 D 78 N.S6.04
Hydrophobic ICL2 L 144 34x54 s8s9 P 131 N.s8s9.02
Polar ICL2 L 141 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 141 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 141 34x51 S16 Y 249 C.S16.03
Hydrophobic TM4 P 149 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM5 L 227 5x65 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 144 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 144 34x54 S5 Y 63 N.S5.12
Hydrophobic TM3 I 137 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 137 3x54 s5s6 L 71 N.s5s6.08
Polar ICL2 G 147 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 G 147 34x57 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 G 147 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 I 137 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 137 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 L 141 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 141 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 S 239 6x30 s5s6 L 73 N.s5s6.10
Ionic H8 R 315 8x52 s20c E 405 C.s20c.15
Polar H8 R 315 8x52 s20c E 405 C.s20c.15
Hydrophobic H8 R 315 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 R 315 8x52 s20c E 405 C.s20c.15
Hydrophobic TM3 I 137 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 I 137 3x54 S6 F 75 N.S6.01
Hydrophobic TM5 L 227 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 227 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 L 141 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 141 34x51 S15 I 241 C.S15.14
Hydrophobic ICL2 L 141 34x51 s15s16 T 246 C.s15s16.05