Beta-arrestin-2 - P2Y4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2Y4 74.9
Beta-arrestin-2 77.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 L 231 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 L 231 - s15s16 F 245 C.s15s16.03
Polar ICL2 R 145 34x55 S16 Q 249 C.S16.02
Van-der-waals ICL2 R 145 34x55 S16 Q 249 C.S16.02
Hydrophobic TM2 D 68 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 D 68 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 70 2x39 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 144 34x54 s8s9 A 140 N.s8s9.10
Hydrophobic TM6 S 243 6x34 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 G 136 3x53 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 G 136 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 G 136 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM4 P 149 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 P 149 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 L 227 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL3 L 231 - S6 F 76 N.S6.01
Polar TM6 R 240 6x31 s5s6 G 73 N.s5s6.09
Polar TM6 S 243 6x34 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 S 243 6x34 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 S 243 6x34 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 P 140 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 137 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 137 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 L 144 34x54 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 144 34x54 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 144 34x54 S8 L 130 N.S8.03
Aromatic ICL2 R 145 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL2 R 145 34x55 S16 Y 250 C.S16.03
Polar TM3 R 133 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 G 233 - S6 R 77 N.S6.02
Van-der-waals ICL3 G 233 - S6 R 77 N.S6.02
Hydrophobic TM6 S 234 6x25 S6 F 76 N.S6.01
Van-der-waals TM6 S 234 6x25 S6 F 76 N.S6.01
Hydrophobic ICL2 L 141 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 141 34x51 S16 A 248 C.S16.01
Polar TM6 S 234 6x25 S6 R 77 N.S6.02
Hydrophobic TM6 S 234 6x25 S6 R 77 N.S6.02
Van-der-waals TM6 S 234 6x25 S6 R 77 N.S6.02
Polar ICL2 L 141 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 141 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 141 34x51 S5 Y 64 N.S5.12
Polar ICL2 P 140 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 140 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 140 34x50 S5 Y 64 N.S5.12
Hydrophobic TM7 T 309 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 T 309 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 144 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 144 34x54 S16 Y 250 C.S16.03
Hydrophobic ICL3 P 232 - S6 K 78 N.S6.03
Van-der-waals ICL3 P 232 - S6 K 78 N.S6.03
Polar TM6 R 242 6x33 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 R 242 6x33 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 R 242 6x33 s5s6 D 70 N.s5s6.06
Hydrophobic ICL3 G 233 - S6 K 78 N.S6.03
Hydrophobic H8 G 310 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 R 242 6x33 s5s6 G 73 N.s5s6.09
Polar TM3 R 133 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 133 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 133 3x50 s5s6 L 72 N.s5s6.08
Polar TM6 S 239 6x30 s5s6 S 75 N.s5s6.11
Hydrophobic TM3 H 132 3x49 s5s6 L 72 N.s5s6.08
Polar ICL2 L 141 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 141 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 141 34x51 S16 Y 250 C.S16.03
Polar TM6 S 239 6x30 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 S 239 6x30 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 S 239 6x30 s5s6 G 73 N.s5s6.09
Polar TM5 R 226 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 226 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 226 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 R 242 6x33 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 R 242 6x33 s5s6 V 71 N.s5s6.07
Polar ICL2 L 144 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 144 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 L 144 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 141 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 141 34x51 s15s16 S 246 C.s15s16.04
Polar ICL2 G 147 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 G 147 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 G 147 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 L 141 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 141 34x51 S15 I 242 C.S15.14