Beta-arrestin-2 - P2Y6 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2Y6 84.2
Beta-arrestin-2 79.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 E 227 6x24 S6 D 79 N.S6.04
Van-der-waals TM6 E 227 6x24 S6 D 79 N.S6.04
Hydrophobic ICL2 K 137 34x56 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 K 137 34x56 s5s6 R 66 N.s5s6.02
Hydrophobic TM2 T 59 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 T 59 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 A 237 6x34 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 237 6x34 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 M 240 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 L 300 7x52 s5s6 V 71 N.s5s6.07
Polar H8 K 306 8x48 s5s6 G 73 N.s5s6.09
Hydrophobic H8 K 306 8x48 s5s6 G 73 N.s5s6.09
Van-der-waals H8 K 306 8x48 s5s6 G 73 N.s5s6.09
Hydrophobic ICL2 L 132 34x51 s15s16 L 244 C.s15s16.02
Van-der-waals ICL2 L 132 34x51 s15s16 L 244 C.s15s16.02
Ionic ICL1 R 56 12x49 s5s6 E 67 N.s5s6.03
Polar ICL1 R 56 12x49 s5s6 E 67 N.s5s6.03
Hydrophobic ICL1 R 56 12x49 s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 R 56 12x49 s5s6 E 67 N.s5s6.03
Polar TM2 T 61 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 61 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic H8 Q 305 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 Q 305 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 A 237 6x34 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 237 6x34 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 132 34x51 S5 F 62 N.S5.10
Hydrophobic ICL2 L 132 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 132 34x51 S5 Y 64 N.S5.12
Hydrophobic TM6 R 234 6x31 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 L 132 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 132 34x51 S15 I 242 C.S15.14
Hydrophobic ICL1 A 57 12x50 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 L 132 34x51 S9 C 141 N.S9.01
Hydrophobic TM3 G 127 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 G 127 3x53 s5s6 L 69 N.s5s6.05
Polar ICL2 K 137 34x56 S16 Y 250 C.S16.03
Van-der-waals ICL2 K 137 34x56 S16 Y 250 C.S16.03
Polar ICL2 P 131 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 131 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 131 34x50 S5 Y 64 N.S5.12
Hydrophobic TM3 R 124 3x50 s5s6 L 72 N.s5s6.08
Ionic TM4 R 141 4x39 s8s9 E 135 N.s8s9.05
Polar TM4 R 141 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 R 141 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 R 141 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 I 128 3x54 S6 F 76 N.S6.01
Polar ICL2 L 132 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 132 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 132 34x51 S16 Y 250 C.S16.03
Hydrophobic TM3 R 124 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 124 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 I 128 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 128 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 R 233 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 L 132 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 132 34x51 s15s16 S 246 C.s15s16.04
Polar ICL2 K 137 34x56 S5 Y 64 N.S5.12
Hydrophobic ICL2 K 137 34x56 S5 Y 64 N.S5.12
Van-der-waals ICL2 K 137 34x56 S5 Y 64 N.S5.12
Polar H8 R 311 8x53 s20c Y 404 C.s20c.14
Hydrophobic TM7 F 301 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 215 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 L 215 5x61 s5s6 L 72 N.s5s6.08
Polar ICL1 R 56 12x49 s20c Y 404 C.s20c.14
Aromatic ICL1 R 56 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL1 R 56 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 R 56 12x49 s20c Y 404 C.s20c.14
Hydrophobic TM3 I 128 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 128 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 L 219 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 219 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 P 134 34x53 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 132 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 132 34x51 S16 A 248 C.S16.01
Hydrophobic TM6 A 241 6x38 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 R 60 2x38 s5s6 R 66 N.s5s6.02
Hydrophobic TM4 G 140 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 G 140 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 I 128 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 128 3x54 s5s6 L 69 N.s5s6.05
Ionic TM6 E 232 6x29 s9s10 K 158 N.s9s10.09
Polar TM6 E 232 6x29 s9s10 K 158 N.s9s10.09
Polar TM2 T 59 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 59 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 59 2x37 s5s6 D 68 N.s5s6.04