Arrestin-C - P2Y6 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2Y6 81.7
Arrestin-C 79.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 132 34x51 s15s16 V 239 C.s15s16.01
Van-der-waals ICL2 L 132 34x51 s15s16 V 239 C.s15s16.01
Hydrophobic ICL3 P 225 - S6 K 73 N.S6.03
Ionic H8 K 307 8x49 s5s6 D 62 N.s5s6.03
Polar H8 K 307 8x49 s5s6 D 62 N.s5s6.03
Hydrophobic H8 K 307 8x49 s5s6 D 62 N.s5s6.03
Van-der-waals H8 K 307 8x49 s5s6 D 62 N.s5s6.03
Polar ICL2 L 132 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 L 132 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 L 132 34x51 s15s16 Y 241 C.s15s16.03
Polar ICL2 P 134 34x53 S16 D 244 C.S16.01
Hydrophobic ICL2 P 134 34x53 S16 D 244 C.S16.01
Van-der-waals ICL2 P 134 34x53 S16 D 244 C.S16.01
Hydrophobic TM6 A 237 6x34 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 237 6x34 s5s6 L 69 N.s5s6.10
Hydrophobic H8 Q 305 8x47 s5s6 E 65 N.s5s6.06
Van-der-waals H8 Q 305 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 K 137 34x56 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 K 137 34x56 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 A 133 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 A 133 34x52 S16 D 244 C.S16.01
Polar TM6 E 227 6x24 S6 Y 76 N.S6.06
Van-der-waals TM6 E 227 6x24 S6 Y 76 N.S6.06
Polar ICL2 L 132 34x51 S16 D 244 C.S16.01
Polar ICL2 K 137 34x56 S5 Y 59 N.S5.12
Hydrophobic ICL2 K 137 34x56 S5 Y 59 N.S5.12
Van-der-waals ICL2 K 137 34x56 S5 Y 59 N.S5.12
Hydrophobic TM6 E 227 6x24 S6 D 74 N.S6.04
Van-der-waals TM6 E 227 6x24 S6 D 74 N.S6.04
Hydrophobic TM6 A 237 6x34 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 A 237 6x34 s5s6 I 67 N.s5s6.08
Polar TM6 R 233 6x30 S6 R 72 N.S6.02
Ionic ICL1 R 56 12x49 s5s6 D 62 N.s5s6.03
Polar ICL1 R 56 12x49 s5s6 D 62 N.s5s6.03
Van-der-waals ICL1 R 56 12x49 s5s6 D 62 N.s5s6.03
Hydrophobic TM3 G 127 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 G 127 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 G 127 3x53 S6 F 71 N.S6.01
Hydrophobic ICL2 L 132 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 L 132 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 P 134 34x53 s15s16 L 243 C.s15s16.05
Ionic ICL2 K 137 34x56 S16 D 244 C.S16.01
Polar ICL2 K 137 34x56 S16 D 244 C.S16.01
Hydrophobic ICL2 K 137 34x56 S16 D 244 C.S16.01
Van-der-waals ICL2 K 137 34x56 S16 D 244 C.S16.01
Hydrophobic TM5 L 215 5x61 s5s6 I 67 N.s5s6.08
Polar TM3 R 124 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 124 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 124 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 M 240 6x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 M 240 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 P 131 34x50 S6 F 71 N.S6.01
Hydrophobic TM3 I 120 3x46 s5s6 V 66 N.s5s6.07
Hydrophobic H8 Q 305 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 Q 305 8x47 s5s6 V 66 N.s5s6.07
Polar ICL2 P 131 34x50 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 P 131 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 131 34x50 s15s16 Y 241 C.s15s16.03
Ionic H8 K 307 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 K 307 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 K 307 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic TM2 T 59 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 59 2x37 s5s6 D 63 N.s5s6.04
Ionic TM6 R 233 6x30 S6 D 74 N.S6.04
Polar TM6 R 233 6x30 S6 D 74 N.S6.04
Polar ICL2 L 132 34x51 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 L 132 34x51 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 L 132 34x51 s15s16 L 243 C.s15s16.05
Hydrophobic H8 R 310 8x52 s9s10 K 157 N.s9s10.12
Van-der-waals H8 R 310 8x52 s9s10 K 157 N.s9s10.12
Polar ICL1 A 57 12x50 s5s6 R 61 N.s5s6.02
Hydrophobic ICL1 A 57 12x50 s5s6 R 61 N.s5s6.02
Van-der-waals ICL1 A 57 12x50 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 R 124 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 124 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 P 131 34x50 S5 Y 59 N.S5.12
Hydrophobic TM5 L 219 5x65 s5s6 L 69 N.s5s6.10
Polar TM6 E 227 6x24 S6 V 77 N.S6.07
Hydrophobic TM6 E 227 6x24 S6 V 77 N.S6.07
Van-der-waals TM6 E 227 6x24 S6 V 77 N.S6.07
Hydrophobic TM6 A 241 6x38 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 K 137 34x56 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 R 138 34x57 s8s9 A 133 N.s8s9.07
Polar ICL2 K 137 34x56 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 K 137 34x56 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 K 137 34x56 s15s16 S 242 C.s15s16.04
Polar TM2 T 61 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 61 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM5 Y 212 5x58 s5s6 I 67 N.s5s6.08
Hydrophobic TM7 F 301 7x53 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 I 128 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 128 3x54 S6 F 71 N.S6.01
Hydrophobic TM6 R 233 6x30 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 I 128 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 128 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 132 34x51 s15s16 L 240 C.s15s16.02
Van-der-waals ICL2 L 132 34x51 s15s16 L 240 C.s15s16.02
Polar ICL2 P 131 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 P 131 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 131 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic TM2 T 61 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 T 61 2x39 s5s6 V 66 N.s5s6.07