S-arrestin - P2Y6 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2Y6 81.5
S-arrestin 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM5 D 223 5x69 S6 R 85 N.S6.03
Van-der-waals TM5 D 223 5x69 S6 R 85 N.S6.03
Hydrophobic TM3 I 128 3x54 s5s6 V 78 N.s5s6.07
Polar H8 K 307 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 K 307 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 307 8x49 s5s6 D 77 N.s5s6.06
Polar ICL2 P 134 34x53 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 P 134 34x53 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 P 134 34x53 s8s9 K 145 N.s8s9.09
Hydrophobic TM6 M 240 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 M 240 6x37 s5s6 I 79 N.s5s6.08
Polar ICL2 K 137 34x56 S16 Y 259 C.S16.03
Hydrophobic TM3 I 128 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 128 3x54 S6 F 83 N.S6.01
Polar TM6 E 227 6x24 S6 F 89 N.S6.07
Hydrophobic TM6 E 227 6x24 S6 F 89 N.S6.07
Van-der-waals TM6 E 227 6x24 S6 F 89 N.S6.07
Ionic H8 E 314 8x56 s9s10 K 170 N.s9s10.12
Hydrophobic TM6 V 244 6x41 s5s6 I 79 N.s5s6.08
Polar H8 Q 305 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 Q 305 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 Q 305 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 L 132 34x51 S9 C 147 N.S9.01
Polar ICL2 A 133 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 A 133 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 A 133 34x52 S16 D 257 C.S16.01
Ionic TM6 R 233 6x30 S6 D 86 N.S6.04
Polar TM6 R 233 6x30 S6 D 86 N.S6.04
Hydrophobic TM6 R 233 6x30 S6 D 86 N.S6.04
Van-der-waals TM6 R 233 6x30 S6 D 86 N.S6.04
Polar TM6 R 233 6x30 S6 R 84 N.S6.02
Polar H8 K 306 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 K 306 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 306 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 A 230 6x27 S6 R 85 N.S6.03
Ionic ICL1 R 56 12x49 s5s6 D 75 N.s5s6.04
Polar ICL1 R 56 12x49 s5s6 D 75 N.s5s6.04
Hydrophobic ICL1 R 56 12x49 s5s6 D 75 N.s5s6.04
Polar ICL2 P 131 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 131 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 131 34x50 S5 Y 71 N.S5.12
Polar ICL2 L 132 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 L 132 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 L 132 34x51 s15s16 S 255 C.s15s16.04
Polar ICL2 L 132 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 L 132 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 132 34x51 S16 Y 259 C.S16.03
Polar ICL2 A 133 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 P 134 34x53 S16 D 257 C.S16.01
Van-der-waals ICL2 P 134 34x53 S16 D 257 C.S16.01
Hydrophobic ICL2 K 137 34x56 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 K 137 34x56 s8s9 K 145 N.s8s9.09
Polar ICL2 P 131 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 P 131 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 P 131 34x50 s15s16 S 255 C.s15s16.04
Polar ICL2 L 132 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 L 132 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 L 132 34x51 S16 D 257 C.S16.01
Polar TM6 E 227 6x24 S6 Y 88 N.S6.06
Hydrophobic TM6 E 227 6x24 S6 Y 88 N.S6.06
Van-der-waals TM6 E 227 6x24 S6 Y 88 N.S6.06
Hydrophobic TM6 E 227 6x24 S6 L 87 N.S6.05
Hydrophobic TM2 T 59 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 T 59 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM3 R 124 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 124 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 R 234 6x31 S6 R 85 N.S6.03
Van-der-waals TM6 R 234 6x31 S6 R 85 N.S6.03
Hydrophobic H8 R 310 8x52 s9s10 K 170 N.s9s10.12
Van-der-waals H8 R 310 8x52 s9s10 K 170 N.s9s10.12
Hydrophobic TM2 T 59 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 T 59 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic TM3 H 130 3x56 s15s16 S 255 C.s15s16.04
Ionic H8 K 307 8x49 s5s6 D 75 N.s5s6.04
Polar H8 K 307 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 K 307 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 K 307 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic TM5 Y 212 5x58 s5s6 I 79 N.s5s6.08
Ionic TM6 R 233 6x30 s9s10 E 165 N.s9s10.07
Polar TM6 R 233 6x30 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 233 6x30 s9s10 E 165 N.s9s10.07
Hydrophobic TM3 I 128 3x54 s5s6 L 81 N.s5s6.10
Polar ICL2 K 137 34x56 S5 Y 71 N.S5.12
Hydrophobic ICL2 K 137 34x56 S5 Y 71 N.S5.12
Van-der-waals ICL2 K 137 34x56 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 131 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 131 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic H8 K 306 8x48 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 L 132 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 132 34x51 S15 V 251 C.S15.14
Hydrophobic TM3 G 127 3x53 S6 F 83 N.S6.01
Hydrophobic ICL2 L 132 34x51 s15s16 S 256 C.s15s16.05
Hydrophobic ICL2 L 132 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 132 34x51 S5 Y 71 N.S5.12
Hydrophobic TM3 R 124 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 124 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 A 237 6x34 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 237 6x34 s5s6 L 81 N.s5s6.10
Ionic H8 K 306 8x48 s9s10 D 166 N.s9s10.08
Polar H8 K 306 8x48 s9s10 D 166 N.s9s10.08
Hydrophobic H8 K 306 8x48 s9s10 D 166 N.s9s10.08
Van-der-waals H8 K 306 8x48 s9s10 D 166 N.s9s10.08
Hydrophobic ICL1 R 55 12x48 s20c R 398 C.s20c.17
Van-der-waals ICL1 R 55 12x48 s20c R 398 C.s20c.17
Ionic H8 K 307 8x49 s5s6 E 74 N.s5s6.03
Polar H8 K 307 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic H8 K 307 8x49 s5s6 E 74 N.s5s6.03
Van-der-waals H8 K 307 8x49 s5s6 E 74 N.s5s6.03
Van-der-waals ICL2 K 137 34x56 s8s9 D 142 N.s8s9.06
Hydrophobic H8 Q 305 8x47 s5s6 G 80 N.s5s6.09