Beta-arrestin-1 - P2RY8 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2RY8 76.8
Beta-arrestin-1 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar H8 R 298 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 R 298 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM2 S 58 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 P 128 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 128 34x50 S5 Y 63 N.S5.12
Polar TM6 Q 231 6x30 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 Q 231 6x30 s5s6 T 74 N.s5s6.11
Hydrophobic TM2 S 56 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 S 56 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 L 129 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 129 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL3 A 226 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 A 226 - s15s16 F 244 C.s15s16.03
Hydrophobic TM3 G 124 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 G 124 3x53 s5s6 L 68 N.s5s6.05
Ionic C-term R 322 - s20c E 406 C.s20c.16
Polar C-term R 322 - s20c E 406 C.s20c.16
Hydrophobic C-term R 322 - s20c E 406 C.s20c.16
Van-der-waals C-term R 322 - s20c E 406 C.s20c.16
Hydrophobic ICL3 T 223 - s15s16 F 244 C.s15s16.03
Hydrophobic TM6 R 232 6x31 s5s6 L 73 N.s5s6.10
Polar C-term D 319 - s20c E 407 C.s20c.17
Hydrophobic C-term D 319 - s20c E 407 C.s20c.17
Van-der-waals C-term D 319 - s20c E 407 C.s20c.17
Aromatic ICL3 H 227 - S6 F 75 N.S6.01
Hydrophobic ICL3 H 227 - S6 F 75 N.S6.01
Van-der-waals ICL3 H 227 - S6 F 75 N.S6.01
Hydrophobic TM7 Y 293 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 293 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic C-term L 325 - s20c T 410 C.s20c.20
Polar C-term T 317 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term T 317 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term T 317 - s9s10 K 160 N.s9s10.12
Hydrophobic ICL3 A 226 - S6 F 75 N.S6.01
Van-der-waals ICL3 A 226 - S6 F 75 N.S6.01
Hydrophobic TM6 L 238 6x37 s5s6 L 71 N.s5s6.08
Ionic C-term R 322 - s20c D 401 C.s20c.11
Polar C-term R 322 - s20c D 401 C.s20c.11
Hydrophobic C-term R 322 - s20c D 401 C.s20c.11
Van-der-waals C-term R 322 - s20c D 401 C.s20c.11
Polar ICL2 L 129 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 129 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 P 128 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 128 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 V 125 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 129 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 129 34x51 S15 I 241 C.S15.14
Ionic C-term R 315 - s20c E 407 C.s20c.17
Polar C-term R 315 - s20c E 407 C.s20c.17
Hydrophobic TM6 A 235 6x34 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 235 6x34 s5s6 L 73 N.s5s6.10
Hydrophobic C-term L 318 - s5s6 T 74 N.s5s6.11
Polar C-term T 320 - s20c E 406 C.s20c.16
Hydrophobic C-term T 320 - s20c E 406 C.s20c.16
Van-der-waals C-term T 320 - s20c E 406 C.s20c.16
Hydrophobic C-term L 318 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term L 318 - s9s10 K 160 N.s9s10.12
Polar C-term D 316 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term D 316 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term D 316 - s9s10 K 160 N.s9s10.12
Polar ICL3 A 226 - S6 R 76 N.S6.02
Hydrophobic ICL3 A 226 - S6 R 76 N.S6.02
Van-der-waals ICL3 A 226 - S6 R 76 N.S6.02
Hydrophobic ICL1 R 55 - s8s9 T 136 N.s8s9.07
Polar TM3 Y 127 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 Y 127 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 Y 127 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic H8 R 298 8x48 s5s6 G 72 N.s5s6.09
Van-der-waals C-term D 319 - s9s10 K 160 N.s9s10.12
Polar C-term R 315 - s9s10 K 160 N.s9s10.12
Polar C-term T 320 - s20c E 405 C.s20c.15
Hydrophobic C-term T 320 - s20c E 405 C.s20c.15
Van-der-waals C-term T 320 - s20c E 405 C.s20c.15
Hydrophobic C-term T 320 - s20c E 404 C.s20c.14
Van-der-waals C-term T 320 - s20c E 404 C.s20c.14
Hydrophobic TM3 V 125 3x54 s5s6 L 73 N.s5s6.10
Ionic TM6 E 230 6x29 s9s10 K 157 N.s9s10.09
Polar TM6 E 230 6x29 s9s10 K 157 N.s9s10.09
Hydrophobic TM3 V 125 3x54 S6 F 75 N.S6.01
Polar H8 E 299 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 E 299 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 E 299 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic TM2 M 62 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic ICL3 H 227 - s5s6 T 74 N.s5s6.11
Van-der-waals ICL3 H 227 - s5s6 T 74 N.s5s6.11
Polar C-term T 320 - s20c E 407 C.s20c.17
Hydrophobic C-term T 320 - s20c E 407 C.s20c.17
Van-der-waals C-term T 320 - s20c E 407 C.s20c.17
Hydrophobic C-term R 322 - s20c K 403 C.s20c.13
Polar C-term R 321 - s20c E 407 C.s20c.17
Hydrophobic C-term R 321 - s20c E 407 C.s20c.17
Van-der-waals C-term R 321 - s20c E 407 C.s20c.17
Hydrophobic C-term R 322 - s20c R 395 C.s20c.05
Van-der-waals C-term R 322 - s20c R 395 C.s20c.05
Polar C-term L 318 - s8s9 K 138 N.s8s9.09
Polar C-term E 323 - s20c G 411 C.s20c.21
Hydrophobic TM5 T 216 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 Q 231 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic C-term R 321 - s20c E 406 C.s20c.16
Van-der-waals C-term R 321 - s20c E 406 C.s20c.16
Polar C-term T 317 - S10 R 165 N.S10.03
Van-der-waals C-term T 317 - S10 R 165 N.S10.03
Hydrophobic TM3 R 121 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic H8 S 297 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 297 8x47 s5s6 D 69 N.s5s6.06
Polar C-term R 322 - s20c D 402 C.s20c.12
Hydrophobic C-term R 322 - s20c D 402 C.s20c.12
Van-der-waals C-term R 322 - s20c D 402 C.s20c.12
Hydrophobic TM6 A 239 6x38 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 235 6x34 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 235 6x34 s5s6 L 71 N.s5s6.08
Polar ICL2 S 130 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 S 130 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 L 238 6x37 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 L 238 6x37 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 121 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 121 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 129 34x51 S9 C 140 N.S9.01
Hydrophobic TM5 L 220 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 220 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 V 125 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 L 129 34x51 S16 A 247 C.S16.01
Hydrophobic ICL3 H 227 - s5s6 L 73 N.s5s6.10
Van-der-waals ICL3 H 227 - s5s6 L 73 N.s5s6.10
Ionic C-term D 319 - s8s9 K 138 N.s8s9.09
Ionic ICL3 E 225 - S6 K 77 N.S6.03
Polar ICL3 E 225 - S6 K 77 N.S6.03
Hydrophobic ICL3 E 225 - S6 K 77 N.S6.03
Van-der-waals ICL3 E 225 - S6 K 77 N.S6.03
Hydrophobic H8 S 297 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 S 297 8x47 s5s6 V 70 N.s5s6.07