S-arrestin - P2RY8 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2RY8 78.4
S-arrestin 80.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 18.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic C-term L 352 - s10s11 E 187 C.s10s11.04
Van-der-waals C-term L 352 - s10s11 E 187 C.s10s11.04
Ionic TM6 R 229 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 Q 231 6x30 s5s6 E 74 N.s5s6.03
Van-der-waals TM6 Q 231 6x30 s5s6 E 74 N.s5s6.03
Polar TM4 R 137 4x39 s8s9 Q 141 N.s8s9.05
Hydrophobic TM4 R 137 4x39 s8s9 Q 141 N.s8s9.05
Van-der-waals TM4 R 137 4x39 s8s9 Q 141 N.s8s9.05
Hydrophobic ICL2 L 129 34x51 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 L 129 34x51 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 L 129 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 L 129 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 P 128 34x50 s15s16 Y 254 C.s15s16.03
Polar ICL3 H 227 - S6 R 84 N.S6.02
Aromatic ICL3 H 227 - S6 R 84 N.S6.02
Hydrophobic ICL3 H 227 - S6 R 84 N.S6.02
Van-der-waals ICL3 H 227 - S6 R 84 N.S6.02
Polar C-term R 354 - s10s11 E 187 C.s10s11.04
Hydrophobic C-term R 354 - s10s11 E 187 C.s10s11.04
Van-der-waals C-term R 354 - s10s11 E 187 C.s10s11.04
Hydrophobic TM6 R 232 6x31 s5s6 L 81 N.s5s6.10
Hydrophobic C-term L 325 - s20c N 386 C.s20c.05
Van-der-waals C-term L 325 - s20c N 386 C.s20c.05
Polar TM2 S 56 2x37 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 S 56 2x37 s5s6 D 77 N.s5s6.06
Van-der-waals TM2 S 56 2x37 s5s6 D 77 N.s5s6.06
Ionic H8 R 298 8x48 s5s6 E 74 N.s5s6.03
Polar H8 R 298 8x48 s5s6 E 74 N.s5s6.03
Hydrophobic H8 R 298 8x48 s5s6 E 74 N.s5s6.03
Van-der-waals H8 R 298 8x48 s5s6 E 74 N.s5s6.03
Hydrophobic C-term E 356 - s3s4 V 39 N.s3s4.02
Van-der-waals C-term E 356 - s3s4 V 39 N.s3s4.02
Hydrophobic TM3 G 124 3x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 G 124 3x53 s5s6 V 78 N.s5s6.07
Hydrophobic H8 S 297 8x47 s5s6 I 76 N.s5s6.05
Van-der-waals H8 S 297 8x47 s5s6 I 76 N.s5s6.05
Hydrophobic TM7 A 296 7x56 s5s6 I 76 N.s5s6.05
Polar C-term F 359 - s17s18 T 314 C.s17s18.30
Van-der-waals C-term F 359 - s17s18 T 314 C.s17s18.30
Hydrophobic TM3 V 125 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM2 V 59 2x40 s5s6 I 76 N.s5s6.05
Polar C-term R 329 - s20c E 392 C.s20c.11
Van-der-waals C-term R 329 - s20c E 392 C.s20c.11
Hydrophobic TM2 M 62 2x43 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 M 62 2x43 s5s6 I 76 N.s5s6.05
Polar ICL2 S 130 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 S 130 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 S 130 34x52 S16 D 257 C.S16.01
Polar TM7 A 296 7x56 s5s6 G 80 N.s5s6.09
Polar C-term R 321 - s17s18 K 304 C.s17s18.20
Van-der-waals C-term R 321 - s17s18 K 304 C.s17s18.20
Hydrophobic TM6 A 239 6x38 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 G 124 3x53 S6 F 83 N.S6.01
Hydrophobic C-term F 359 - s17s18 I 316 C.s17s18.32
Van-der-waals C-term F 359 - s17s18 I 316 C.s17s18.32
Polar C-term R 329 - s20c A 393 C.s20c.12
Hydrophobic ICL2 K 132 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 K 132 34x54 s8s9 K 145 N.s8s9.09
Polar C-term S 357 - s17s18 I 316 C.s17s18.32
Van-der-waals C-term S 357 - s17s18 I 316 C.s17s18.32
Polar TM6 Q 231 6x30 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 Q 231 6x30 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 Q 231 6x30 s5s6 G 80 N.s5s6.09
Hydrophobic ICL1 M 52 - s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 L 129 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 129 34x51 S5 Y 71 N.S5.12
Polar C-term Q 353 - s10s11 E 187 C.s10s11.04
Van-der-waals C-term Q 353 - s10s11 E 187 C.s10s11.04
Hydrophobic C-term F 359 - S18 L 328 C.S18.02
Van-der-waals C-term F 359 - S18 L 328 C.S18.02
Polar ICL2 K 132 34x54 S16 Y 259 C.S16.03
Hydrophobic ICL2 K 132 34x54 S16 Y 259 C.S16.03
Van-der-waals ICL2 K 132 34x54 S16 Y 259 C.S16.03
Hydrophobic C-term F 359 - S15 N 250 C.S15.13
Ionic C-term E 356 - S19 R 358 C.S19.10
Polar C-term E 356 - S19 R 358 C.S19.10
Hydrophobic C-term E 356 - S19 R 358 C.S19.10
Van-der-waals C-term E 356 - S19 R 358 C.S19.10
Hydrophobic ICL2 L 129 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 129 34x51 S15 V 251 C.S15.14
Ionic ICL2 R 135 34x57 s5s6 D 77 N.s5s6.06
Polar ICL2 R 135 34x57 s5s6 D 77 N.s5s6.06
Van-der-waals ICL2 R 135 34x57 s5s6 D 77 N.s5s6.06
Hydrophobic C-term E 356 - s17s18 I 315 C.s17s18.31
Hydrophobic TM3 V 125 3x54 S6 F 83 N.S6.01
Hydrophobic TM6 A 235 6x34 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 235 6x34 s5s6 L 81 N.s5s6.10
Hydrophobic C-term F 326 - s20c E 392 C.s20c.11
Van-der-waals C-term F 326 - s20c E 392 C.s20c.11
Ionic ICL2 K 132 34x54 s8s9 D 142 N.s8s9.06
Polar ICL2 K 132 34x54 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 K 132 34x54 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 K 132 34x54 s8s9 D 142 N.s8s9.06
Hydrophobic TM3 R 121 3x50 s5s6 I 79 N.s5s6.08
Polar TM2 S 58 2x39 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 S 58 2x39 s5s6 D 77 N.s5s6.06
Van-der-waals TM2 S 58 2x39 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 L 220 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 220 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 L 238 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 238 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 L 129 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 L 129 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic TM6 Q 231 6x30 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 V 125 3x54 s5s6 V 78 N.s5s6.07
Ionic C-term D 316 - s9s10 K 170 N.s9s10.12
Ionic ICL3 H 227 - s9s10 E 165 N.s9s10.07
Polar ICL3 H 227 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 H 227 - s9s10 E 165 N.s9s10.07
Hydrophobic C-term E 356 - s10s11 P 185 C.s10s11.02
Van-der-waals C-term E 356 - s10s11 P 185 C.s10s11.02
Polar C-term F 359 - S18 S 330 C.S18.04
Hydrophobic C-term F 359 - S18 S 330 C.S18.04
Van-der-waals C-term F 359 - S18 S 330 C.S18.04
Hydrophobic TM3 R 121 3x50 s5s6 D 77 N.s5s6.06
Van-der-waals TM3 R 121 3x50 s5s6 D 77 N.s5s6.06
Polar C-term T 317 - s1s2 R 22 N.s1s2.02
Hydrophobic C-term T 317 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term T 317 - s1s2 R 22 N.s1s2.02
Van-der-waals ICL3 E 225 - S6 R 84 N.S6.02
Hydrophobic C-term F 359 - s17s18 R 322 C.s17s18.38
Van-der-waals C-term F 359 - s17s18 R 322 C.s17s18.38
Hydrophobic C-term V 358 - S19 R 358 C.S19.10
Van-der-waals C-term V 358 - S19 R 358 C.S19.10
Polar TM6 Q 231 6x30 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 Q 231 6x30 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 Q 231 6x30 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 A 235 6x34 s5s6 I 79 N.s5s6.08
Polar ICL2 S 130 34x52 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 S 130 34x52 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 S 130 34x52 s15s16 S 255 C.s15s16.04
Polar ICL2 R 135 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic ICL3 E 225 - S6 R 85 N.S6.03
Van-der-waals ICL3 E 225 - S6 R 85 N.S6.03
Polar ICL2 P 128 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 128 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 128 34x50 S5 Y 71 N.S5.12
Hydrophobic C-term L 325 - s17s18 K 304 C.s17s18.20
Van-der-waals C-term L 325 - s17s18 K 304 C.s17s18.20