Arrestin-C - P2RY10 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2RY10 76.0
Arrestin-C 80.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 Q 233 - S6 F 71 N.S6.01
Polar ICL2 R 142 34x54 s8s9 G 129 N.s8s9.03
Van-der-waals ICL2 R 142 34x54 s8s9 G 129 N.s8s9.03
Polar ICL3 M 230 - S6 K 73 N.S6.03
Hydrophobic ICL3 M 230 - S6 K 73 N.S6.03
Van-der-waals ICL3 M 230 - S6 K 73 N.S6.03
Hydrophobic ICL2 F 139 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 F 139 34x51 S16 D 244 C.S16.01
Hydrophobic TM3 F 134 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 F 139 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 F 139 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 R 142 34x54 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 R 142 34x54 s8s9 A 133 N.s8s9.07
Hydrophobic TM6 M 244 6x37 s5s6 V 66 N.s5s6.07
Polar ICL3 A 231 - S6 K 73 N.S6.03
Hydrophobic ICL3 A 231 - S6 K 73 N.S6.03
Van-der-waals ICL3 A 231 - S6 K 73 N.S6.03
Hydrophobic ICL2 R 142 34x54 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 R 142 34x54 s8s9 K 135 N.s8s9.09
Hydrophobic ICL3 A 231 - s15s16 L 240 C.s15s16.02
Hydrophobic TM2 I 70 2x40 s5s6 V 66 N.s5s6.07
Polar ICL3 A 231 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 A 231 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 A 231 - s15s16 Y 241 C.s15s16.03
Ionic H8 D 314 8x52 s9s10 K 157 N.s9s10.12
Polar H8 D 314 8x52 s9s10 K 157 N.s9s10.12
Van-der-waals H8 D 314 8x52 s9s10 K 157 N.s9s10.12
Polar TM6 E 237 6x30 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 E 237 6x30 s5s6 T 70 N.s5s6.11
Hydrophobic ICL2 P 138 34x50 S6 F 71 N.S6.01
Hydrophobic TM2 N 67 2x37 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 N 67 2x37 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 131 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 131 3x50 s5s6 I 67 N.s5s6.08
Polar ICL2 R 142 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 R 142 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 R 142 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic ICL3 F 232 - S6 R 72 N.S6.02
Hydrophobic TM5 L 225 5x65 s5s6 L 69 N.s5s6.10
Polar ICL3 Q 233 - S6 R 72 N.S6.02
Hydrophobic ICL3 Q 233 - S6 R 72 N.S6.02
Van-der-waals ICL3 Q 233 - S6 R 72 N.S6.02
Polar ICL2 R 142 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 R 142 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 R 142 34x54 s5s6 R 61 N.s5s6.02
Ionic TM2 K 68 2x38 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 K 68 2x38 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 K 68 2x38 s5s6 D 63 N.s5s6.04
Polar ICL2 P 138 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 138 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 138 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 A 141 34x53 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 A 141 34x53 s8s9 K 135 N.s8s9.09
Hydrophobic ICL3 F 232 - S6 F 71 N.S6.01
Van-der-waals ICL3 F 232 - S6 F 71 N.S6.01
Hydrophobic TM2 K 68 2x38 s5s6 R 61 N.s5s6.02
Van-der-waals TM2 K 68 2x38 s5s6 R 61 N.s5s6.02
Polar ICL3 Q 233 - s5s6 T 70 N.s5s6.11
Hydrophobic ICL3 Q 233 - s5s6 T 70 N.s5s6.11
Van-der-waals ICL3 Q 233 - s5s6 T 70 N.s5s6.11
Polar TM2 N 67 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 N 67 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 N 67 2x37 s5s6 D 63 N.s5s6.04
Polar ICL2 R 142 34x54 s8s9 P 128 N.s8s9.02
Hydrophobic ICL2 R 142 34x54 s8s9 P 128 N.s8s9.02
Van-der-waals ICL2 R 142 34x54 s8s9 P 128 N.s8s9.02
Polar TM7 M 308 7x56 s5s6 G 68 N.s5s6.09
Polar ICL3 F 232 - s15s16 Y 241 C.s15s16.03
Aromatic ICL3 F 232 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 F 232 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 F 232 - s15s16 Y 241 C.s15s16.03
Polar TM7 S 310 7x58 s5s6 E 65 N.s5s6.06
Van-der-waals TM7 S 310 7x58 s5s6 E 65 N.s5s6.06
Polar TM3 F 134 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic TM6 M 244 6x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 M 244 6x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 M 308 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 F 139 34x51 s8s9 G 134 N.s8s9.08
Hydrophobic TM2 M 73 2x43 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 E 237 6x30 s5s6 G 68 N.s5s6.09
Hydrophobic ICL1 K 66 - s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 K 66 - s5s6 D 63 N.s5s6.04
Polar TM7 A 309 7x57 s5s6 V 66 N.s5s6.07
Hydrophobic TM7 A 309 7x57 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 D 143 34x55 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 D 143 34x55 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 F 139 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 F 139 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic TM6 A 241 6x34 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 241 6x34 s5s6 L 69 N.s5s6.10
Polar ICL2 P 138 34x50 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 P 138 34x50 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 P 138 34x50 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 F 139 34x51 s8s9 A 133 N.s8s9.07
Polar ICL2 R 142 34x54 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 R 142 34x54 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 R 142 34x54 s8s9 G 134 N.s8s9.08
Polar ICL2 F 139 34x51 S5 Y 59 N.S5.12
Aromatic ICL2 F 139 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 F 139 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 F 139 34x51 S5 Y 59 N.S5.12
Hydrophobic TM3 L 135 3x54 S6 F 71 N.S6.01
Hydrophobic ICL3 Q 233 - s5s6 L 69 N.s5s6.10
Van-der-waals ICL3 Q 233 - s5s6 L 69 N.s5s6.10
Hydrophobic TM3 L 135 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 L 135 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 F 134 3x53 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 F 134 3x53 s5s6 I 67 N.s5s6.08