S-arrestin - P2RY10 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2RY10 77.0
S-arrestin 80.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 138 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 138 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals TM2 N 67 2x37 s5s6 D 75 N.s5s6.04
Polar ICL2 R 142 34x54 S16 Y 259 C.S16.03
Hydrophobic ICL2 R 142 34x54 S16 Y 259 C.S16.03
Van-der-waals ICL2 R 142 34x54 S16 Y 259 C.S16.03
Hydrophobic TM3 F 134 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 F 134 3x53 S6 F 83 N.S6.01
Polar TM3 R 131 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 131 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 131 3x50 s5s6 V 78 N.s5s6.07
Polar ICL2 R 142 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 R 142 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 142 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 L 135 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 L 135 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 F 134 3x53 s5s6 V 78 N.s5s6.07
Polar TM7 S 310 7x58 s5s6 D 77 N.s5s6.06
Hydrophobic TM7 S 310 7x58 s5s6 D 77 N.s5s6.06
Van-der-waals TM7 S 310 7x58 s5s6 D 77 N.s5s6.06
Ionic H8 R 325 8x63 s20c E 405 C.s20c.24
Polar ICL1 K 66 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL1 K 66 - s8s9 Q 141 N.s8s9.05
Polar ICL2 F 139 34x51 S5 Y 71 N.S5.12
Aromatic ICL2 F 139 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 F 139 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 F 139 34x51 S5 Y 71 N.S5.12
Aromatic ICL3 F 232 - S6 F 83 N.S6.01
Hydrophobic ICL3 F 232 - S6 F 83 N.S6.01
Van-der-waals ICL3 F 232 - S6 F 83 N.S6.01
Polar ICL3 Q 233 - s5s6 T 82 N.s5s6.11
Hydrophobic ICL3 Q 233 - s5s6 T 82 N.s5s6.11
Van-der-waals ICL3 Q 233 - s5s6 T 82 N.s5s6.11
Hydrophobic TM6 A 241 6x34 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 241 6x34 s5s6 L 81 N.s5s6.10
Polar ICL2 P 138 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 138 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 138 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 F 139 34x51 S5 F 69 N.S5.10
Hydrophobic ICL2 F 139 34x51 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 F 139 34x51 s15s16 Y 254 C.s15s16.03
Polar ICL3 A 231 - S6 D 86 N.S6.04
Hydrophobic ICL2 F 139 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 F 139 34x51 S15 V 251 C.S15.14
Hydrophobic TM6 A 241 6x34 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 A 241 6x34 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 Q 233 - S6 R 84 N.S6.02
Van-der-waals ICL3 Q 233 - S6 R 84 N.S6.02
Hydrophobic TM3 R 131 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 131 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 M 230 - S6 R 85 N.S6.03
Van-der-waals ICL3 M 230 - S6 R 85 N.S6.03
Hydrophobic ICL3 A 231 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL3 A 231 - s15s16 Y 254 C.s15s16.03
Polar TM6 S 236 6x29 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 S 236 6x29 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 S 236 6x29 s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 P 138 34x50 S6 F 83 N.S6.01
Hydrophobic TM6 I 235 6x28 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 I 235 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 I 235 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 I 235 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM3 L 135 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 L 135 3x54 S6 F 83 N.S6.01
Polar TM7 E 311 7x59 s5s6 D 77 N.s5s6.06
Hydrophobic TM7 E 311 7x59 s5s6 D 77 N.s5s6.06
Van-der-waals TM7 E 311 7x59 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 L 225 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 G 234 6x27 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 G 234 6x27 s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 F 139 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 F 139 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 F 139 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 F 139 34x51 S16 D 257 C.S16.01
Hydrophobic TM2 A 69 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 A 69 2x39 s5s6 V 78 N.s5s6.07
Polar ICL3 M 230 - S6 D 86 N.S6.04
Hydrophobic ICL3 M 230 - S6 D 86 N.S6.04
Van-der-waals ICL3 M 230 - S6 D 86 N.S6.04
Hydrophobic ICL2 F 139 34x51 S9 C 147 N.S9.01
Polar ICL1 K 66 - s8s9 S 143 N.s8s9.07
Van-der-waals ICL1 K 66 - s8s9 S 143 N.s8s9.07
Hydrophobic ICL3 F 232 - s5s6 L 81 N.s5s6.10
Hydrophobic TM6 M 244 6x37 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 M 244 6x37 s5s6 V 78 N.s5s6.07
Hydrophobic ICL3 A 231 - S6 R 84 N.S6.02
Van-der-waals ICL3 A 231 - S6 R 84 N.S6.02
Polar ICL3 A 231 - S6 R 85 N.S6.03
Hydrophobic ICL3 A 231 - S6 R 85 N.S6.03
Van-der-waals ICL3 A 231 - S6 R 85 N.S6.03
Van-der-waals TM6 E 237 6x30 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 E 237 6x30 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 E 237 6x30 s5s6 L 81 N.s5s6.10
Polar ICL3 F 232 - S6 R 84 N.S6.02
Hydrophobic ICL3 F 232 - S6 R 84 N.S6.02
Van-der-waals ICL3 F 232 - S6 R 84 N.S6.02
Hydrophobic H8 R 318 8x56 s20c R 398 C.s20c.17
Van-der-waals H8 R 318 8x56 s20c R 398 C.s20c.17
Hydrophobic TM6 M 244 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 M 244 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 M 230 - S6 L 87 N.S6.05
Hydrophobic TM3 L 135 3x54 s5s6 I 79 N.s5s6.08