Beta-arrestin-2 - P2Y11 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2Y11 75.4
Beta-arrestin-2 78.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL3 P 236 - S6 K 78 N.S6.03
Hydrophobic ICL2 F 135 34x51 S9 C 141 N.S9.01
Hydrophobic TM3 I 131 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 131 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 L 228 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 G 237 - s15s16 F 245 C.s15s16.03
Hydrophobic C-term Y 338 - s1s2 C 17 N.s1s2.04
Polar ICL2 P 134 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 134 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 134 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL3 G 237 - S6 K 78 N.S6.03
Polar H8 C 332 8x54 s20c D 406 C.s20c.16
Hydrophobic H8 C 332 8x54 s20c D 406 C.s20c.16
Polar ICL2 L 141 34x57 s5s6 R 66 N.s5s6.02
Polar ICL2 A 137 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 A 137 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 A 137 34x53 s5s6 R 66 N.s5s6.02
Polar H8 C 330 8x52 s20c C 409 C.s20c.19
Hydrophobic H8 C 330 8x52 s20c C 409 C.s20c.19
Van-der-waals H8 C 330 8x52 s20c C 409 C.s20c.19
Ionic TM2 H 62 2x37 s5s6 E 67 N.s5s6.03
Polar TM2 H 62 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic TM2 H 62 2x37 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 H 62 2x37 s5s6 E 67 N.s5s6.03
Ionic TM2 H 62 2x37 s5s6 D 68 N.s5s6.04
Polar TM2 H 62 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 H 62 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 H 62 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL3 G 237 - S6 R 77 N.S6.02
Van-der-waals ICL3 G 237 - S6 R 77 N.S6.02
Hydrophobic TM7 A 324 7x56 s5s6 L 72 N.s5s6.08
Polar TM3 R 127 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 127 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 127 3x50 s5s6 V 71 N.s5s6.07
Ionic ICL2 R 138 34x54 s8s9 D 136 N.s8s9.06
Polar ICL2 R 138 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 R 138 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 R 138 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic TM7 A 324 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 A 324 7x56 s5s6 V 71 N.s5s6.07
Polar ICL2 R 138 34x54 S8 L 130 N.S8.03
Hydrophobic ICL2 R 138 34x54 S8 L 130 N.S8.03
Van-der-waals ICL2 R 138 34x54 S8 L 130 N.S8.03
Hydrophobic TM2 A 64 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 A 64 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 S 235 - S6 F 76 N.S6.01
Hydrophobic ICL3 S 235 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 S 235 - s15s16 F 245 C.s15s16.03
Polar TM2 A 64 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 A 64 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 A 64 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 138 34x54 S16 Y 250 C.S16.03
Hydrophobic TM6 L 249 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 249 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 F 135 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 F 135 34x51 S16 A 248 C.S16.01
Hydrophobic TM3 I 131 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 131 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM7 A 324 7x56 s5s6 D 70 N.s5s6.06
Hydrophobic ICL3 M 238 - S6 F 76 N.S6.01
Van-der-waals ICL3 M 238 - S6 F 76 N.S6.01
Aromatic ICL2 F 135 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 F 135 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 F 135 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL1 P 60 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 P 60 - s8s9 E 135 N.s8s9.05
Hydrophobic TM2 H 62 2x37 s8s9 D 136 N.s8s9.06
Polar H8 V 325 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 S 139 34x55 S16 Y 250 C.S16.03
Hydrophobic ICL3 P 236 - s15s16 F 245 C.s15s16.03
Polar TM3 V 132 3x55 s15s16 S 246 C.s15s16.04
Polar TM2 P 63 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 P 63 2x38 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 P 63 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 138 34x54 s8s9 A 140 N.s8s9.10
Van-der-waals ICL2 R 138 34x54 s8s9 A 140 N.s8s9.10
Polar H8 C 335 8x57 s1s2 P 15 N.s1s2.02
Hydrophobic H8 C 335 8x57 s1s2 P 15 N.s1s2.02
Hydrophobic ICL3 M 238 - s5s6 L 74 N.s5s6.10
Van-der-waals ICL3 M 238 - s5s6 L 74 N.s5s6.10
Hydrophobic TM3 G 130 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 G 130 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 R 138 34x54 s8s9 P 132 N.s8s9.02
Van-der-waals ICL2 R 138 34x54 s8s9 P 132 N.s8s9.02
Polar TM7 A 324 7x56 s5s6 G 73 N.s5s6.09
Van-der-waals TM7 A 324 7x56 s5s6 G 73 N.s5s6.09
Polar TM3 G 130 3x53 S5 Y 64 N.S5.12
Polar TM3 N 126 3x49 s5s6 D 68 N.s5s6.04
Hydrophobic TM4 P 143 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 P 143 4x39 s8s9 E 135 N.s8s9.05
Polar ICL2 F 135 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 F 135 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 F 135 34x51 S16 Y 250 C.S16.03
Polar TM2 H 62 2x37 s8s9 E 135 N.s8s9.05
Hydrophobic TM2 H 62 2x37 s8s9 E 135 N.s8s9.05
Van-der-waals TM2 H 62 2x37 s8s9 E 135 N.s8s9.05
Ionic ICL1 K 57 - s5s6 E 67 N.s5s6.03
Polar ICL1 K 57 - s5s6 E 67 N.s5s6.03
Hydrophobic ICL1 K 57 - s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 K 57 - s5s6 E 67 N.s5s6.03
Hydrophobic ICL2 P 134 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 134 34x50 s15s16 S 246 C.s15s16.04
Polar TM6 E 242 6x30 s5s6 S 75 N.s5s6.11
Hydrophobic TM3 R 127 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 127 3x50 s5s6 L 72 N.s5s6.08
Polar TM2 H 62 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 F 135 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 F 135 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM6 V 246 6x34 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 246 6x34 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 I 131 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 131 3x54 s5s6 L 72 N.s5s6.08
Polar ICL2 R 138 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 138 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 138 34x54 s5s6 R 66 N.s5s6.02
Polar H8 P 326 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 P 326 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 P 326 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 F 135 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 F 135 34x51 S15 I 242 C.S15.14
Hydrophobic TM3 I 131 3x54 S6 F 76 N.S6.01