S-arrestin - P2Y12 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2Y12 78.1
S-arrestin 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 130 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 F 130 34x51 S15 V 251 C.S15.14
Hydrophobic TM5 T 223 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 T 223 5x72 S6 R 85 N.S6.03
Polar TM5 R 222 5x71 s15s16 V 252 C.s15s16.01
Hydrophobic TM5 L 216 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 216 5x65 s5s6 L 81 N.s5s6.10
Polar ICL2 P 129 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 129 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 129 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL3 V 229 - S6 D 86 N.S6.04
Van-der-waals ICL3 V 229 - S6 D 86 N.S6.04
Ionic TM6 K 233 6x33 s9s10 E 164 N.s9s10.06
Polar TM6 K 233 6x33 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 K 233 6x33 s9s10 E 164 N.s9s10.06
Hydrophobic TM7 L 301 7x56 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 F 130 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 F 130 34x51 S16 D 257 C.S16.01
Ionic TM6 K 232 6x32 S6 D 86 N.S6.04
Polar TM6 K 232 6x32 S6 D 86 N.S6.04
Hydrophobic TM6 K 232 6x32 S6 D 86 N.S6.04
Van-der-waals TM6 K 232 6x32 S6 D 86 N.S6.04
Ionic H8 K 303 8x48 s5s6 E 74 N.s5s6.03
Polar H8 K 303 8x48 s5s6 E 74 N.s5s6.03
Hydrophobic H8 K 303 8x48 s5s6 E 74 N.s5s6.03
Van-der-waals H8 K 303 8x48 s5s6 E 74 N.s5s6.03
Polar ICL2 F 130 34x51 S16 Y 259 C.S16.03
Aromatic ICL2 F 130 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 F 130 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 F 130 34x51 S16 Y 259 C.S16.03
Hydrophobic TM3 K 125 3x53 s5s6 I 76 N.s5s6.05
Polar TM5 R 222 5x71 S6 R 85 N.S6.03
Hydrophobic TM5 R 222 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 R 222 5x71 S6 R 85 N.S6.03
Polar TM5 S 219 5x68 s15s16 L 253 C.s15s16.02
Hydrophobic TM6 V 238 6x38 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 238 6x38 s5s6 L 81 N.s5s6.10
Ionic H8 R 306 8x51 s5s6 D 77 N.s5s6.06
Polar ICL2 F 130 34x51 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 F 130 34x51 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 F 130 34x51 s8s9 K 145 N.s8s9.09
Polar ICL2 P 129 34x50 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 P 129 34x50 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 P 129 34x50 s8s9 K 145 N.s8s9.09
Ionic H8 K 303 8x48 s5s6 D 77 N.s5s6.06
Polar H8 K 303 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 K 303 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 K 303 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 P 129 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 129 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 T 126 3x54 s5s6 L 81 N.s5s6.10
Polar TM3 T 126 3x54 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 T 126 3x54 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 T 126 3x54 s15s16 Y 254 C.s15s16.03
Hydrophobic H8 C 302 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 F 59 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 F 59 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 L 301 7x56 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 L 301 7x56 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 L 216 5x65 S6 F 83 N.S6.01
Van-der-waals TM5 L 216 5x65 S6 F 83 N.S6.01
Hydrophobic TM3 K 125 3x53 s5s6 I 79 N.s5s6.08
Van-der-waals ICL2 F 130 34x51 s15s16 S 255 C.s15s16.04
Polar ICL2 T 132 34x53 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 T 132 34x53 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 T 132 34x53 s8s9 D 142 N.s8s9.06
Polar ICL2 F 130 34x51 S5 Y 71 N.S5.12
Aromatic ICL2 F 130 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 F 130 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 F 130 34x51 S5 Y 71 N.S5.12
Ionic C-term K 314 - s20c E 405 C.s20c.24
Polar C-term K 314 - s20c E 405 C.s20c.24
Hydrophobic C-term K 314 - s20c E 405 C.s20c.24
Van-der-waals C-term K 314 - s20c E 405 C.s20c.24
Polar ICL2 S 133 34x54 s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 S 133 34x54 s8s9 D 142 N.s8s9.06
Polar ICL2 K 131 34x52 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 K 131 34x52 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 K 131 34x52 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 F 130 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 F 130 34x51 S8 L 136 N.S8.03
Polar TM5 R 222 5x71 s15s16 Y 254 C.s15s16.03
Polar TM6 N 235 6x35 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 N 235 6x35 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 N 235 6x35 s5s6 G 80 N.s5s6.09
Polar TM6 V 238 6x38 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 V 238 6x38 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 V 238 6x38 s5s6 I 79 N.s5s6.08
Polar TM3 R 122 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 R 122 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 122 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 P 129 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 P 129 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic TM6 K 237 6x37 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 T 132 34x53 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 T 132 34x53 s8s9 K 145 N.s8s9.09
Polar TM6 K 232 6x32 S6 R 84 N.S6.02
Hydrophobic TM6 K 232 6x32 S6 R 84 N.S6.02
Van-der-waals TM6 K 232 6x32 S6 R 84 N.S6.02
Hydrophobic TM5 S 219 5x68 S6 F 83 N.S6.01
Van-der-waals TM5 S 219 5x68 S6 F 83 N.S6.01
Hydrophobic TM5 S 219 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 F 130 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 F 130 34x51 S9 C 147 N.S9.01