Beta-arrestin-1 - P2Y13 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2Y13 80.1
Beta-arrestin-1 80.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 17.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM3 R 141 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 L 253 6x34 s5s6 D 69 N.s5s6.06
Van-der-waals TM6 L 253 6x34 s5s6 D 69 N.s5s6.06
Polar C-term N 350 - s20c N 417 C.s20c.27
Hydrophobic C-term N 350 - s20c N 417 C.s20c.27
Van-der-waals C-term N 350 - s20c N 417 C.s20c.27
Hydrophobic ICL2 L 149 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 L 149 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 P 148 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 V 257 6x38 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 257 6x38 s5s6 L 71 N.s5s6.08
Ionic TM3 K 144 3x53 s5s6 D 67 N.s5s6.04
Polar TM3 K 144 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 K 144 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 K 144 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 I 145 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 145 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 P 148 34x50 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 V 235 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 K 144 3x53 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 145 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 L 149 34x51 S8 L 129 N.S8.03
Ionic H8 K 323 8x49 s5s6 E 66 N.s5s6.03
Hydrophobic H8 K 323 8x49 s5s6 E 66 N.s5s6.03
Polar TM5 K 234 5x64 s15s16 N 245 C.s15s16.04
Polar ICL2 P 148 34x50 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 P 148 34x50 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 P 148 34x50 s5s6 R 65 N.s5s6.02
Polar ICL3 K 241 - s15s16 F 244 C.s15s16.03
Polar TM6 L 253 6x34 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 L 253 6x34 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 L 253 6x34 s5s6 G 72 N.s5s6.09
Hydrophobic ICL3 K 241 - S6 F 75 N.S6.01
Hydrophobic TM3 I 145 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 145 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 P 148 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 148 34x50 S5 Y 63 N.S5.12
Hydrophobic TM3 K 144 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 K 144 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 L 149 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 149 34x51 S5 Y 63 N.S5.12
Hydrophobic TM4 P 157 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 P 157 4x39 s8s9 E 134 N.s8s9.05
Polar C-term T 348 - s20c N 416 C.s20c.26
Hydrophobic C-term T 348 - s20c N 416 C.s20c.26
Van-der-waals C-term T 348 - s20c N 416 C.s20c.26
Hydrophobic ICL2 L 149 34x51 S9 C 140 N.S9.01
Polar TM3 I 146 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 I 146 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 149 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 149 34x51 S15 I 241 C.S15.14
Polar C-term T 348 - s20c N 417 C.s20c.27
Hydrophobic C-term T 348 - s20c N 417 C.s20c.27
Van-der-waals C-term T 348 - s20c N 417 C.s20c.27
Hydrophobic H8 K 322 8x48 s5s6 V 70 N.s5s6.07
Hydrophobic ICL3 S 242 - S6 F 75 N.S6.01
Van-der-waals ICL3 S 242 - S6 F 75 N.S6.01
Ionic H8 K 322 8x48 s20c E 405 C.s20c.15
Polar H8 K 322 8x48 s20c E 405 C.s20c.15
Hydrophobic H8 K 322 8x48 s20c E 405 C.s20c.15
Van-der-waals H8 K 322 8x48 s20c E 405 C.s20c.15
Hydrophobic ICL2 L 149 34x51 s5s6 R 65 N.s5s6.02
Polar TM6 S 244 6x25 S6 D 78 N.S6.04
Van-der-waals TM6 S 244 6x25 S6 D 78 N.S6.04
Hydrophobic H8 K 322 8x48 s5s6 E 66 N.s5s6.03
Polar ICL2 L 149 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 149 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 149 34x51 S16 Y 249 C.S16.03
Polar H8 K 323 8x49 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 S 238 5x68 s5s6 L 73 N.s5s6.10
Hydrophobic TM7 L 320 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 L 320 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 141 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 141 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 S 238 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 S 238 5x68 s15s16 F 244 C.s15s16.03