Beta-arrestin-2 - P2Y13 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
P2Y13 78.6
Beta-arrestin-2 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Van-der-waals TM6 L 253 6x34 s5s6 S 75 N.s5s6.11
Polar TM3 R 141 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 141 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 141 3x50 s5s6 L 72 N.s5s6.08
Polar ICL2 P 148 34x50 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 P 148 34x50 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 P 148 34x50 s8s9 T 137 N.s8s9.07
Polar ICL2 R 150 34x52 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 R 150 34x52 s8s9 T 137 N.s8s9.07
Hydrophobic H8 K 322 8x48 s5s6 V 71 N.s5s6.07
Van-der-waals H8 K 322 8x48 s5s6 V 71 N.s5s6.07
Polar ICL2 N 151 34x53 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 N 151 34x53 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 N 151 34x53 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 L 149 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 149 34x51 S16 A 248 C.S16.01
Hydrophobic C-term L 353 - H1 K 108 N.H1.09
Polar ICL2 N 151 34x53 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 N 151 34x53 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 N 151 34x53 s8s9 E 135 N.s8s9.05
Hydrophobic TM7 L 320 7x56 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 K 144 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 K 144 3x53 s5s6 L 69 N.s5s6.05
Ionic H8 K 322 8x48 s5s6 E 67 N.s5s6.03
Polar H8 K 322 8x48 s5s6 E 67 N.s5s6.03
Hydrophobic H8 K 322 8x48 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 322 8x48 s5s6 E 67 N.s5s6.03
Polar TM5 K 234 5x64 s15s16 F 245 C.s15s16.03
Polar ICL2 K 155 34x57 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 K 155 34x57 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 K 155 34x57 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 L 253 6x34 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 L 253 6x34 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 V 257 6x38 s5s6 L 74 N.s5s6.10
Hydrophobic TM7 L 320 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 L 320 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 V 235 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 V 235 5x65 s5s6 L 74 N.s5s6.10
Polar ICL3 K 241 - S6 K 78 N.S6.03
Hydrophobic TM3 I 145 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 I 145 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 145 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 P 148 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 148 34x50 s15s16 S 246 C.s15s16.04
Polar ICL2 P 148 34x50 s8s9 G 138 N.s8s9.08
Hydrophobic ICL2 P 148 34x50 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 P 148 34x50 s8s9 G 138 N.s8s9.08
Hydrophobic TM5 S 238 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 S 238 5x68 S6 F 76 N.S6.01
Hydrophobic TM6 V 257 6x38 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 257 6x38 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 S 242 - S6 F 76 N.S6.01
Van-der-waals ICL3 S 242 - S6 F 76 N.S6.01
Hydrophobic ICL2 L 149 34x51 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 L 149 34x51 s8s9 G 138 N.s8s9.08
Ionic ICL3 K 241 - s17s18 E 314 C.s17s18.39
Polar ICL3 K 241 - s17s18 E 314 C.s17s18.39
Van-der-waals ICL3 K 241 - s17s18 E 314 C.s17s18.39
Hydrophobic H8 C 321 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 C 321 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 L 149 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 149 34x51 S5 Y 64 N.S5.12
Hydrophobic TM2 F 78 2x39 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 P 148 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 148 34x50 S5 Y 64 N.S5.12
Hydrophobic TM5 S 238 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 S 238 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 N 151 34x53 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 L 149 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 149 34x51 S15 I 242 C.S15.14
Ionic TM4 K 156 4x38 s8s9 E 135 N.s8s9.05
Polar TM4 K 156 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 K 156 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 K 156 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM6 V 257 6x38 s5s6 G 73 N.s5s6.09
Hydrophobic TM7 F 319 7x55 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 F 319 7x55 s5s6 V 71 N.s5s6.07
Polar C-term K 335 - s20c Q 407 C.s20c.17
Van-der-waals C-term K 335 - s20c Q 407 C.s20c.17
Polar H8 K 323 8x49 s20c Y 404 C.s20c.14
Hydrophobic H8 K 323 8x49 s20c Y 404 C.s20c.14
Van-der-waals H8 K 323 8x49 s20c Y 404 C.s20c.14
Hydrophobic TM3 K 144 3x53 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 L 253 6x34 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 L 253 6x34 s5s6 G 73 N.s5s6.09
Polar ICL2 L 149 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 149 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 149 34x51 S16 Y 250 C.S16.03