Beta-arrestin-1 - P2Y14 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2Y14 80.9
Beta-arrestin-1 79.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 18.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 127 34x51 S8 L 129 N.S8.03
Van-der-waals ICL2 L 127 34x51 S8 L 129 N.S8.03
Ionic ICL3 K 219 - s17s18 E 313 C.s17s18.39
Polar ICL3 K 219 - s17s18 E 313 C.s17s18.39
Van-der-waals ICL3 K 219 - s17s18 E 313 C.s17s18.39
Hydrophobic TM2 F 56 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 F 56 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 119 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 119 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 I 209 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 K 122 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 K 122 3x53 s5s6 L 68 N.s5s6.05
Polar ICL2 T 129 34x53 s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 T 129 34x53 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 T 129 34x53 s17s18 R 285 C.s17s18.11
Hydrophobic TM7 L 298 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 123 3x54 S6 F 75 N.S6.01
Polar TM5 K 212 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 K 212 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 K 212 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 S 231 6x34 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 S 231 6x34 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 123 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 123 3x54 s5s6 L 73 N.s5s6.10
Polar TM6 S 231 6x34 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 S 231 6x34 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 S 220 - s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 T 129 34x53 s8s9 G 132 N.s8s9.03
Van-der-waals TM5 S 216 5x68 S6 F 75 N.S6.01
Hydrophobic C-term D 319 - s9s10 K 157 N.s9s10.09
Polar C-term N 318 - s5s6 D 69 N.s5s6.06
Hydrophobic H8 Q 300 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 Q 300 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 S 216 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 S 216 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 P 126 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 126 34x50 S5 Y 63 N.S5.12
Polar TM3 R 119 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 119 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 119 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 123 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 123 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic C-term L 320 - s9s10 K 157 N.s9s10.09
Van-der-waals C-term L 320 - s9s10 K 157 N.s9s10.09
Polar ICL2 Q 133 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 Q 133 34x57 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Q 133 34x57 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 K 122 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 I 123 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 123 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 I 213 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 I 213 5x65 s5s6 L 73 N.s5s6.10
Ionic TM3 K 122 3x53 s5s6 D 67 N.s5s6.04
Polar TM3 K 122 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 K 122 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 K 122 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 I 235 6x38 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 235 6x38 s5s6 L 71 N.s5s6.08
Ionic TM2 K 54 2x37 s20c E 404 C.s20c.14
Polar TM2 K 54 2x37 s20c E 404 C.s20c.14
Hydrophobic TM2 K 54 2x37 s20c E 404 C.s20c.14
Van-der-waals TM2 K 54 2x37 s20c E 404 C.s20c.14
Polar TM6 N 234 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 I 213 5x65 S6 F 75 N.S6.01
Van-der-waals TM5 I 213 5x65 S6 F 75 N.S6.01
Ionic C-term K 326 - s9s10 E 155 N.s9s10.07
Polar C-term K 326 - s9s10 E 155 N.s9s10.07
Hydrophobic C-term K 326 - s9s10 E 155 N.s9s10.07
Van-der-waals C-term K 326 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL2 L 127 34x51 S9 C 140 N.S9.01
Hydrophobic C-term D 319 - s9s10 I 158 N.s9s10.10
Van-der-waals C-term D 319 - s9s10 I 158 N.s9s10.10
Hydrophobic TM2 K 54 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 K 54 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 L 127 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 127 34x51 S15 I 241 C.S15.14
Polar ICL3 S 220 - S6 R 76 N.S6.02
Polar TM5 K 212 5x64 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 K 212 5x64 s15s16 N 245 C.s15s16.04
Van-der-waals TM5 K 212 5x64 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 T 129 34x53 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 T 129 34x53 s8s9 D 135 N.s8s9.06
Hydrophobic C-term I 322 - s9s10 I 158 N.s9s10.10
Hydrophobic TM5 H 217 5x69 S6 F 75 N.S6.01
Hydrophobic TM5 I 209 5x61 s5s6 L 73 N.s5s6.10
Polar TM3 V 124 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 V 124 3x55 s15s16 N 245 C.s15s16.04
Polar ICL3 K 219 - S6 K 77 N.S6.03
Van-der-waals ICL3 K 219 - S6 K 77 N.S6.03
Hydrophobic ICL2 L 127 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 127 34x51 S16 Y 249 C.S16.03
Ionic C-term D 319 - S9 K 147 N.S9.08
Ionic H8 E 304 8x52 s9s10 K 160 N.s9s10.12
Hydrophobic H8 C 299 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 I 238 6x41 s5s6 L 71 N.s5s6.08
Hydrophobic TM4 S 134 4x38 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 S 134 4x38 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 L 127 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL3 S 220 - S6 K 77 N.S6.03
Van-der-waals ICL3 S 220 - S6 K 77 N.S6.03
Hydrophobic TM7 L 298 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 L 298 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic C-term S 323 - s9s10 E 155 N.s9s10.07
Van-der-waals C-term S 323 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL2 L 127 34x51 S16 A 247 C.S16.01