Arrestin-C - P2Y14 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
P2Y14 78.4
Arrestin-C 79.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM6 T 225 6x28 s9s10 T 154 N.s9s10.09
Hydrophobic TM6 T 225 6x28 s9s10 T 154 N.s9s10.09
Van-der-waals TM6 T 225 6x28 s9s10 T 154 N.s9s10.09
Polar C-term R 327 - s20c D 385 C.s20c.19
Hydrophobic C-term R 327 - s20c D 385 C.s20c.19
Van-der-waals C-term R 327 - s20c D 385 C.s20c.19
Ionic H8 R 303 8x51 s5s6 E 65 N.s5s6.06
Polar H8 R 303 8x51 s5s6 E 65 N.s5s6.06
Van-der-waals H8 R 303 8x51 s5s6 E 65 N.s5s6.06
Hydrophobic TM7 L 298 7x56 s5s6 I 67 N.s5s6.08
Polar C-term I 322 - s20c E 383 C.s20c.17
Hydrophobic C-term I 322 - s20c E 383 C.s20c.17
Van-der-waals C-term I 322 - s20c E 383 C.s20c.17
Hydrophobic TM5 I 213 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 R 222 6x25 S9 F 146 N.S9.10
Van-der-waals TM6 R 222 6x25 S9 F 146 N.S9.10
Hydrophobic TM2 F 56 2x39 s5s6 I 67 N.s5s6.08
Polar TM6 R 222 6x25 S9 C 147 N.S9.11
Hydrophobic TM6 R 222 6x25 S9 C 147 N.S9.11
Van-der-waals TM6 R 222 6x25 S9 C 147 N.S9.11
Polar H8 Q 300 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic H8 Q 300 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 Q 300 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic TM2 K 54 2x37 s5s6 R 61 N.s5s6.02
Van-der-waals TM2 K 54 2x37 s5s6 R 61 N.s5s6.02
Polar H8 Q 300 8x48 s5s6 D 62 N.s5s6.03
Hydrophobic H8 Q 300 8x48 s5s6 D 62 N.s5s6.03
Van-der-waals H8 Q 300 8x48 s5s6 D 62 N.s5s6.03
Hydrophobic TM6 I 235 6x38 s5s6 I 67 N.s5s6.08
Polar TM6 R 222 6x25 s9s10 V 155 N.s9s10.10
Hydrophobic TM6 R 222 6x25 s9s10 V 155 N.s9s10.10
Van-der-waals TM6 R 222 6x25 s9s10 V 155 N.s9s10.10
Polar TM7 L 298 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic TM7 L 298 7x56 s5s6 V 66 N.s5s6.07
Van-der-waals TM7 L 298 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 L 127 34x51 s17s18 E 310 C.s17s18.39
Van-der-waals ICL2 L 127 34x51 s17s18 E 310 C.s17s18.39
Polar TM3 R 119 3x50 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 R 119 3x50 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 R 119 3x50 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 T 129 34x53 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 T 129 34x53 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 T 129 34x53 s15s16 L 243 C.s15s16.05
Polar TM6 S 221 6x24 s9s10 P 151 N.s9s10.03
Hydrophobic TM6 S 221 6x24 s9s10 P 151 N.s9s10.03
Van-der-waals TM6 S 221 6x24 s9s10 P 151 N.s9s10.03
Hydrophobic TM6 R 222 6x25 S9 K 144 N.S9.08
Van-der-waals TM6 R 222 6x25 S9 K 144 N.S9.08
Hydrophobic TM6 R 222 6x25 s9s10 E 153 N.s9s10.08
Van-der-waals TM6 R 222 6x25 s9s10 E 153 N.s9s10.08
Hydrophobic TM6 T 225 6x28 s9s10 E 153 N.s9s10.08
Hydrophobic C-term S 323 - s20c E 383 C.s20c.17
Van-der-waals C-term S 323 - s20c E 383 C.s20c.17
Ionic C-term K 326 - s20c E 383 C.s20c.17
Polar C-term K 326 - s20c E 383 C.s20c.17
Hydrophobic C-term K 326 - s20c E 383 C.s20c.17
Van-der-waals C-term K 326 - s20c E 383 C.s20c.17
Polar C-term R 327 - s20c E 386 C.s20c.20
Hydrophobic C-term R 327 - s20c E 386 C.s20c.20
Van-der-waals C-term R 327 - s20c E 386 C.s20c.20
Polar C-term K 326 - s20c A 382 C.s20c.15
Hydrophobic C-term K 326 - s20c A 382 C.s20c.15
Van-der-waals C-term K 326 - s20c A 382 C.s20c.15
Hydrophobic TM6 S 221 6x24 S9 F 146 N.S9.10
Van-der-waals TM6 S 221 6x24 S9 F 146 N.S9.10
Hydrophobic TM3 R 119 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 119 3x50 s5s6 I 67 N.s5s6.08
Polar H8 C 299 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic H8 C 299 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 C 299 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 T 129 34x53 s15s16 Y 241 C.s15s16.03
Hydrophobic C-term I 325 - s20c V 380 C.s20c.13
Van-der-waals C-term I 325 - s20c V 380 C.s20c.13
Hydrophobic C-term I 325 - s20c G 384 C.s20c.18
Van-der-waals C-term I 325 - s20c G 384 C.s20c.18
Hydrophobic C-term R 324 - s20c G 384 C.s20c.18
Van-der-waals C-term R 324 - s20c G 384 C.s20c.18
Hydrophobic ICL3 L 218 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 L 218 - s9s10 E 152 N.s9s10.07
Hydrophobic C-term I 325 - s20c A 382 C.s20c.15
Van-der-waals C-term I 325 - s20c A 382 C.s20c.15
Hydrophobic C-term I 325 - s20c D 385 C.s20c.19
Van-der-waals C-term I 325 - s20c D 385 C.s20c.19
Hydrophobic TM6 S 221 6x24 S5 M 52 N.S5.05
Van-der-waals TM6 S 221 6x24 S5 M 52 N.S5.05
Hydrophobic ICL3 S 220 - S5 M 52 N.S5.05
Polar C-term I 322 - s20c G 384 C.s20c.18
Hydrophobic ICL3 K 219 - S6 V 77 N.S6.07
Van-der-waals ICL3 K 219 - S6 V 77 N.S6.07
Polar ICL2 P 126 34x50 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 P 126 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 126 34x50 s15s16 Y 241 C.s15s16.03
Hydrophobic H8 Q 300 8x48 s5s6 V 66 N.s5s6.07
Van-der-waals H8 Q 300 8x48 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 P 126 34x50 S6 K 73 N.S6.03
Hydrophobic H8 P 301 8x49 s5s6 V 66 N.s5s6.07
Van-der-waals H8 P 301 8x49 s5s6 V 66 N.s5s6.07
Hydrophobic ICL3 S 220 - S6 V 77 N.S6.07
Hydrophobic C-term K 326 - s20c D 385 C.s20c.19
Van-der-waals C-term K 326 - s20c D 385 C.s20c.19
Polar C-term R 327 - s20c S 388 C.s20c.22
Hydrophobic C-term R 327 - s20c S 388 C.s20c.22
Van-der-waals C-term R 327 - s20c S 388 C.s20c.22
Van-der-waals TM6 N 223 6x26 s9s10 K 157 N.s9s10.12
Polar TM6 S 221 6x24 s9s10 E 153 N.s9s10.08
Van-der-waals TM6 S 221 6x24 s9s10 E 153 N.s9s10.08
Hydrophobic C-term I 322 - s20c V 380 C.s20c.13
Van-der-waals C-term I 322 - s20c V 380 C.s20c.13
Hydrophobic C-term K 326 - s20c G 384 C.s20c.18
Van-der-waals C-term K 326 - s20c G 384 C.s20c.18
Polar ICL2 W 128 34x52 s17s18 E 310 C.s17s18.39
Polar C-term G 328 - s20c D 385 C.s20c.19
Hydrophobic C-term G 328 - s20c D 385 C.s20c.19
Van-der-waals C-term G 328 - s20c D 385 C.s20c.19
Polar TM6 N 223 6x26 s9s10 S 156 N.s9s10.11
Hydrophobic TM6 N 223 6x26 s9s10 S 156 N.s9s10.11
Polar TM3 R 119 3x50 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 R 119 3x50 s5s6 D 63 N.s5s6.04
Polar TM6 N 223 6x26 s9s10 V 155 N.s9s10.10
Hydrophobic TM6 N 223 6x26 s9s10 V 155 N.s9s10.10
Van-der-waals TM6 N 223 6x26 s9s10 V 155 N.s9s10.10
Polar TM6 S 231 6x34 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 K 122 3x53 S6 F 71 N.S6.01
Polar TM6 R 222 6x25 s9s10 T 154 N.s9s10.09
Hydrophobic TM6 R 222 6x25 s9s10 T 154 N.s9s10.09
Van-der-waals TM6 R 222 6x25 s9s10 T 154 N.s9s10.09
Hydrophobic TM3 R 119 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 119 3x50 s5s6 V 66 N.s5s6.07
Polar C-term N 318 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term N 318 - s9s10 K 157 N.s9s10.12
Hydrophobic H8 P 301 8x49 s5s6 D 63 N.s5s6.04
Hydrophobic C-term K 326 - s20c E 386 C.s20c.20
Van-der-waals C-term K 326 - s20c E 386 C.s20c.20
Polar TM6 R 222 6x25 S9 S 145 N.S9.09
Van-der-waals TM6 R 222 6x25 S9 S 145 N.S9.09
Hydrophobic TM3 K 122 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 K 122 3x53 s5s6 L 64 N.s5s6.05
Polar TM6 S 224 6x27 s9s10 E 152 N.s9s10.07
Hydrophobic TM2 F 56 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 F 56 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 L 127 34x51 s15s16 L 240 C.s15s16.02
Van-der-waals ICL2 L 127 34x51 s15s16 L 240 C.s15s16.02
Polar C-term R 324 - s20c D 385 C.s20c.19
Hydrophobic C-term R 324 - s20c D 385 C.s20c.19
Van-der-waals C-term R 324 - s20c D 385 C.s20c.19
Hydrophobic TM6 S 226 6x29 s9s10 T 154 N.s9s10.09
Van-der-waals TM6 S 226 6x29 s9s10 T 154 N.s9s10.09
Hydrophobic TM6 S 224 6x27 s9s10 T 154 N.s9s10.09
Polar TM6 R 222 6x25 s9s10 D 159 N.s9s10.14
Hydrophobic TM6 R 222 6x25 s9s10 D 159 N.s9s10.14
Van-der-waals TM6 R 222 6x25 s9s10 D 159 N.s9s10.14
Hydrophobic C-term D 321 - s20c V 380 C.s20c.13
Van-der-waals C-term D 321 - s20c V 380 C.s20c.13
Ionic TM2 K 54 2x37 s5s6 D 63 N.s5s6.04
Polar TM2 K 54 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 K 54 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 K 54 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 I 123 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 123 3x54 s5s6 L 69 N.s5s6.10
Polar C-term S 323 - s20c G 384 C.s20c.18
Hydrophobic C-term S 323 - s20c G 384 C.s20c.18
Van-der-waals C-term S 323 - s20c G 384 C.s20c.18
Van-der-waals ICL3 S 220 - S6 D 74 N.S6.04
Hydrophobic TM6 S 221 6x24 s9s10 E 152 N.s9s10.07
Van-der-waals TM6 S 221 6x24 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 N 223 6x26 s9s10 T 154 N.s9s10.09
Van-der-waals TM6 N 223 6x26 s9s10 T 154 N.s9s10.09
Hydrophobic TM3 K 122 3x53 s15s16 Y 241 C.s15s16.03
Van-der-waals TM3 K 122 3x53 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 R 222 6x25 S10 Y 160 N.S10.01
Van-der-waals TM6 R 222 6x25 S10 Y 160 N.S10.01
Hydrophobic ICL3 K 219 - S5 M 52 N.S5.05
Van-der-waals ICL3 K 219 - S5 M 52 N.S5.05
Hydrophobic TM6 N 223 6x26 S10 Y 160 N.S10.01
Van-der-waals TM6 N 223 6x26 S10 Y 160 N.S10.01
Hydrophobic C-term I 325 - s20c E 381 C.s20c.14
Van-der-waals C-term I 325 - s20c E 381 C.s20c.14
Hydrophobic C-term R 324 - s20c E 383 C.s20c.17
Hydrophobic C-term I 325 - s20c E 383 C.s20c.17
Van-der-waals C-term I 325 - s20c E 383 C.s20c.17