S-arrestin - P2Y14 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
P2Y14 79.2
S-arrestin 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 213 5x65 S6 F 83 N.S6.01
Van-der-waals TM5 I 213 5x65 S6 F 83 N.S6.01
Polar TM2 K 54 2x37 s8s9 S 143 N.s8s9.07
Hydrophobic ICL2 L 127 34x51 S8 L 136 N.S8.03
Hydrophobic ICL2 L 127 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 T 129 34x53 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 T 129 34x53 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 T 129 34x53 s8s9 K 145 N.s8s9.09
Ionic TM2 K 54 2x37 s5s6 D 75 N.s5s6.04
Polar TM2 K 54 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 K 54 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 K 54 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM3 I 123 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic TM7 L 298 7x56 s5s6 I 79 N.s5s6.08
Polar ICL3 K 219 - s17s18 T 323 C.s17s18.39
Van-der-waals ICL3 K 219 - s17s18 T 323 C.s17s18.39
Hydrophobic TM3 I 123 3x54 s5s6 I 76 N.s5s6.05
Polar TM3 K 122 3x53 s5s6 Q 73 N.s5s6.02
Hydrophobic TM3 K 122 3x53 s5s6 Q 73 N.s5s6.02
Van-der-waals TM3 K 122 3x53 s5s6 Q 73 N.s5s6.02
Polar ICL2 Q 133 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 Q 133 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 Q 133 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic TM7 L 298 7x56 s5s6 D 77 N.s5s6.06
Van-der-waals TM7 L 298 7x56 s5s6 D 77 N.s5s6.06
Polar C-term N 318 - S10 R 175 N.S10.03
Hydrophobic C-term N 318 - S10 R 175 N.S10.03
Van-der-waals C-term N 318 - S10 R 175 N.S10.03
Polar ICL2 P 126 34x50 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 P 126 34x50 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 P 126 34x50 s8s9 K 145 N.s8s9.09
Hydrophobic TM5 I 209 5x61 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 I 123 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 123 3x54 S6 F 83 N.S6.01
Polar ICL2 W 128 34x52 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 W 128 34x52 s8s9 K 145 N.s8s9.09
Polar TM7 L 298 7x56 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 L 298 7x56 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 L 298 7x56 s5s6 V 78 N.s5s6.07
Polar TM5 K 212 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 K 212 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 K 212 5x64 s15s16 Y 254 C.s15s16.03
Polar TM5 S 216 5x68 s15s16 L 253 C.s15s16.02
Polar ICL3 S 220 - S6 D 86 N.S6.04
Hydrophobic TM2 F 56 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 F 56 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 K 122 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 K 122 3x53 s5s6 I 76 N.s5s6.05
Polar C-term Q 317 - s9s10 K 170 N.s9s10.12
Hydrophobic C-term Q 317 - s9s10 K 170 N.s9s10.12
Van-der-waals C-term Q 317 - s9s10 K 170 N.s9s10.12
Polar ICL3 K 219 - S6 R 85 N.S6.03
Hydrophobic ICL3 K 219 - S6 R 85 N.S6.03
Van-der-waals ICL3 K 219 - S6 R 85 N.S6.03
Hydrophobic TM5 Y 206 5x58 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 S 231 6x34 s5s6 I 79 N.s5s6.08
Polar ICL3 S 220 - S6 R 85 N.S6.03
Hydrophobic ICL3 S 220 - S6 R 85 N.S6.03
Van-der-waals ICL3 S 220 - S6 R 85 N.S6.03
Hydrophobic C-term R 324 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term R 324 - s1s2 R 22 N.s1s2.02
Polar ICL2 L 127 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 L 127 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 L 127 34x51 S16 D 257 C.S16.01
Ionic C-term D 321 - S10 R 175 N.S10.03
Polar C-term D 321 - S10 R 175 N.S10.03
Hydrophobic C-term D 321 - S10 R 175 N.S10.03
Van-der-waals C-term D 321 - S10 R 175 N.S10.03
Polar C-term N 318 - s9s10 K 170 N.s9s10.12
Hydrophobic C-term N 318 - s9s10 K 170 N.s9s10.12
Van-der-waals C-term N 318 - s9s10 K 170 N.s9s10.12
Hydrophobic TM5 I 213 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 I 213 5x65 s5s6 L 81 N.s5s6.10
Polar TM5 S 216 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 S 216 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 S 216 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 I 123 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 P 126 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 126 34x50 S5 Y 71 N.S5.12
Hydrophobic TM6 S 231 6x34 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 S 231 6x34 s5s6 L 81 N.s5s6.10
Polar ICL2 L 127 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 L 127 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 127 34x51 S16 Y 259 C.S16.03
Polar TM3 R 119 3x50 s5s6 D 75 N.s5s6.04
Van-der-waals TM3 R 119 3x50 s5s6 D 75 N.s5s6.04
Polar C-term A 316 - s9s10 K 170 N.s9s10.12
Hydrophobic C-term A 316 - s9s10 K 170 N.s9s10.12
Van-der-waals C-term A 316 - s9s10 K 170 N.s9s10.12
Polar TM6 N 234 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 N 234 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 N 234 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 L 127 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 127 34x51 S15 V 251 C.S15.14
Hydrophobic TM3 R 119 3x50 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 R 119 3x50 s5s6 I 76 N.s5s6.05
Hydrophobic TM5 K 212 5x64 s15s16 S 255 C.s15s16.04
Van-der-waals TM5 K 212 5x64 s15s16 S 255 C.s15s16.04
Hydrophobic TM6 I 235 6x38 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 I 235 6x38 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 R 119 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic C-term I 322 - s5s6 E 74 N.s5s6.03
Van-der-waals C-term I 322 - s5s6 E 74 N.s5s6.03
Polar H8 Q 300 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 Q 300 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 Q 300 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic C-term L 320 - s9s10 K 170 N.s9s10.12
Van-der-waals C-term L 320 - s9s10 K 170 N.s9s10.12
Hydrophobic TM3 R 119 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 119 3x50 s5s6 V 78 N.s5s6.07