S-arrestin - PAC1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
PAC1 70.2
S-arrestin 79.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
01
iPTM Score: 0.4
01
PAE mean: 20.5
031


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:
D04I08s5s6R03D04L05S6Q05s8s9S04s15s16Y03S16ArrestinR-D-S6x41T-F-R2x46GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsArrestin segments:s5s6S6s8s9s15s16S16GPCR segments:TM2ICL2ICL3TM6

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x392x433x503x533x543x553x565x655x685x696x366x407x538x49C.S16.03C.S16.01C.s15s16.04C.s15s16.03C.S15.14N.S9.01N.s8s9.09N.s8s9.05N.S8.03N.S6.05N.S6.04N.S6.03N.S6.01N.s5s6.10N.s5s6.08N.s5s6.07N.s5s6.06N.s5s6.05N.s5s6.04N.S5.12Res. Pos.PAC1 (AFM_PACR_HUMAN_ARRS_HUMAN)- (AFM_PACR_HUMAN_ARRS_HUMAN)---------------RHLLLVELKLSLYERHLLLVELKLSLYETDDVIYIFSDLYVYRDLLCQK

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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