Beta-arrestin-2 - PAR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
PAR1 67.2
Beta-arrestin-2 77.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM2 K 135 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic TM2 K 135 2x37 s5s6 E 67 N.s5s6.03
Van-der-waals TM7 Y 373 7x55 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 P 207 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 207 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL3 V 302 - S6 F 76 N.S6.01
Polar H8 S 375 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 S 375 8x47 s5s6 V 71 N.s5s6.07
Polar ICL2 M 208 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 M 208 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 M 208 34x51 S16 Y 250 C.S16.03
Hydrophobic TM5 L 297 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 297 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 P 207 34x50 S6 F 76 N.S6.01
Polar TM7 A 374 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic TM7 A 374 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 A 374 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 V 302 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 M 208 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 M 208 34x51 S15 I 242 C.S15.14
Polar H8 S 376 8x48 s5s6 G 73 N.s5s6.09
Van-der-waals H8 S 376 8x48 s5s6 G 73 N.s5s6.09
Van-der-waals ICL2 L 211 34x54 S5 Y 64 N.S5.12
Hydrophobic H8 S 375 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 V 204 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 V 204 3x54 s5s6 L 74 N.s5s6.10
Polar ICL2 R 214 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 Q 209 34x52 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 Q 209 34x52 s15s16 T 247 C.s15s16.05
Hydrophobic ICL2 L 211 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 L 211 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 V 204 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 V 204 3x54 S6 F 76 N.S6.01
Hydrophobic TM5 I 293 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 R 310 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 R 310 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 V 302 - S6 K 78 N.S6.03
Van-der-waals ICL3 V 302 - S6 K 78 N.S6.03
Hydrophobic ICL2 Q 209 34x52 S16 A 248 C.S16.01
Polar H8 S 376 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 S 376 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 S 376 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 V 204 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic H8 E 377 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 E 377 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 R 200 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 200 3x50 s5s6 L 72 N.s5s6.08
Polar TM6 K 307 6x30 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 K 307 6x30 s5s6 S 75 N.s5s6.11
Polar TM3 R 200 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 200 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 200 3x50 s5s6 V 71 N.s5s6.07
Polar TM6 K 307 6x30 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 K 307 6x30 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 307 6x30 s5s6 G 73 N.s5s6.09
Polar ICL2 P 207 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 207 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 207 34x50 S5 Y 64 N.S5.12
Hydrophobic TM2 A 137 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 A 137 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 L 314 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 V 302 - S6 R 77 N.S6.02
Van-der-waals ICL3 V 302 - S6 R 77 N.S6.02
Polar ICL2 Q 209 34x52 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 Q 209 34x52 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 A 203 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 203 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 M 208 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 M 208 34x51 S16 A 248 C.S16.01
Polar ICL2 M 208 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 M 208 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 M 208 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 M 208 34x51 S8 L 130 N.S8.03
Hydrophobic ICL2 M 208 34x51 S9 C 141 N.S9.01
Van-der-waals ICL2 M 208 34x51 S9 C 141 N.S9.01
Hydrophobic TM6 K 307 6x30 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 K 307 6x30 s5s6 L 74 N.s5s6.10
Ionic TM2 K 135 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 K 135 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 K 135 2x37 s5s6 D 68 N.s5s6.04
Ionic TM2 K 135 2x37 s5s6 D 70 N.s5s6.06
Polar TM2 K 135 2x37 s5s6 D 70 N.s5s6.06
Van-der-waals TM2 K 135 2x37 s5s6 D 70 N.s5s6.06
Polar ICL2 M 208 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 M 208 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM6 A 311 6x34 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 A 311 6x34 s5s6 L 72 N.s5s6.08