Beta-arrestin-2 - PAR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
PAR3 73.8
Beta-arrestin-2 77.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 195 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 L 289 5x65 S6 F 76 N.S6.01
Hydrophobic TM6 W 296 6x31 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 W 296 6x31 s5s6 L 74 N.s5s6.10
Hydrophobic TM7 M 361 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 M 361 7x56 s5s6 V 71 N.s5s6.07
Polar ICL2 F 199 34x51 S5 Y 64 N.S5.12
Aromatic ICL2 F 199 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 F 199 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 F 199 34x51 S5 Y 64 N.S5.12
Hydrophobic C-term R 365 - s5s6 G 73 N.s5s6.09
Van-der-waals C-term R 365 - s5s6 G 73 N.s5s6.09
Hydrophobic TM5 L 289 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 F 199 34x51 S5 F 62 N.S5.10
Hydrophobic ICL2 R 202 34x54 S5 Y 64 N.S5.12
Polar C-term Y 371 - s5s6 S 75 N.s5s6.11
Hydrophobic C-term Y 371 - s5s6 S 75 N.s5s6.11
Van-der-waals C-term Y 371 - s5s6 S 75 N.s5s6.11
Hydrophobic TM3 A 194 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 194 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 R 202 34x54 s8s9 P 132 N.s8s9.02
Van-der-waals ICL2 R 202 34x54 s8s9 P 132 N.s8s9.02
Polar TM6 Y 299 6x34 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 Y 299 6x34 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 Y 299 6x34 s5s6 L 72 N.s5s6.08
Polar ICL2 F 199 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 F 199 34x51 S16 Y 250 C.S16.03
Ionic C-term R 365 - s5s6 D 70 N.s5s6.06
Polar C-term R 365 - s5s6 D 70 N.s5s6.06
Hydrophobic C-term R 365 - s5s6 D 70 N.s5s6.06
Van-der-waals C-term R 365 - s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 P 198 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 R 191 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 191 3x50 s5s6 L 72 N.s5s6.08
Ionic C-term R 365 - s5s6 E 67 N.s5s6.03
Polar C-term R 365 - s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 F 199 34x51 s15s16 L 244 C.s15s16.02
Van-der-waals ICL2 F 199 34x51 s15s16 L 244 C.s15s16.02
Polar C-term T 364 - s5s6 L 72 N.s5s6.08
Hydrophobic C-term T 364 - s5s6 L 72 N.s5s6.08
Van-der-waals C-term T 364 - s5s6 L 72 N.s5s6.08
Polar ICL2 F 199 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 F 199 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 F 199 34x51 s15s16 S 246 C.s15s16.04
Ionic TM4 K 206 4x38 s5s6 D 68 N.s5s6.04
Polar TM4 K 206 4x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM4 K 206 4x38 s5s6 D 68 N.s5s6.04
Van-der-waals TM4 K 206 4x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM7 M 361 7x56 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 M 361 7x56 s5s6 L 72 N.s5s6.08
Aromatic C-term Y 371 - S6 F 76 N.S6.01
Hydrophobic C-term Y 371 - S6 F 76 N.S6.01
Van-der-waals C-term Y 371 - S6 F 76 N.S6.01
Polar C-term K 374 - S6 K 78 N.S6.03
Hydrophobic C-term K 374 - S6 K 78 N.S6.03
Van-der-waals C-term K 374 - S6 K 78 N.S6.03
Hydrophobic TM3 I 195 3x54 s5s6 L 72 N.s5s6.08
Polar ICL2 R 202 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 202 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 202 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 P 198 34x50 s15s16 F 245 C.s15s16.03
Polar ICL2 R 202 34x54 s8s9 Q 131 N.s8s9.01
Van-der-waals ICL2 R 202 34x54 s8s9 Q 131 N.s8s9.01
Hydrophobic C-term Y 371 - s5s6 L 74 N.s5s6.10
Van-der-waals C-term Y 371 - s5s6 L 74 N.s5s6.10
Polar C-term T 373 - S6 R 77 N.S6.02
Hydrophobic C-term T 373 - S6 R 77 N.S6.02
Van-der-waals C-term T 373 - S6 R 77 N.S6.02
Hydrophobic ICL2 F 199 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 F 199 34x51 S15 I 242 C.S15.14
Hydrophobic TM3 I 195 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 195 3x54 S6 F 76 N.S6.01
Polar C-term L 372 - S6 R 77 N.S6.02
Hydrophobic C-term L 372 - S6 R 77 N.S6.02
Van-der-waals C-term L 372 - S6 R 77 N.S6.02
Hydrophobic ICL2 F 199 34x51 S9 C 141 N.S9.01
Hydrophobic TM3 I 195 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 195 3x54 s5s6 L 74 N.s5s6.10
Polar C-term T 369 - s5s6 S 75 N.s5s6.11
Van-der-waals C-term T 369 - s5s6 S 75 N.s5s6.11
Polar C-term Y 371 - S6 R 77 N.S6.02
Hydrophobic C-term Y 371 - S6 R 77 N.S6.02
Van-der-waals C-term Y 371 - S6 R 77 N.S6.02
Polar ICL2 P 198 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 198 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 198 34x50 S5 Y 64 N.S5.12
Hydrophobic TM6 W 298 6x33 s5s6 L 72 N.s5s6.08
Polar ICL2 Y 201 34x53 s5s6 R 66 N.s5s6.02
Aromatic ICL2 Y 201 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic C-term T 364 - s5s6 G 73 N.s5s6.09
Ionic ICL1 R 124 - s5s6 E 67 N.s5s6.03
Polar ICL1 R 124 - s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 R 124 - s5s6 E 67 N.s5s6.03
Hydrophobic ICL1 R 124 - s20c Y 404 C.s20c.14
Van-der-waals ICL1 R 124 - s20c Y 404 C.s20c.14
Van-der-waals ICL2 R 202 34x54 S9 C 141 N.S9.01
Hydrophobic TM2 I 126 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM4 K 206 4x38 s5s6 R 66 N.s5s6.02
Van-der-waals TM4 K 206 4x38 s5s6 R 66 N.s5s6.02
Polar C-term A 370 - s5s6 S 75 N.s5s6.11
Van-der-waals C-term A 370 - s5s6 S 75 N.s5s6.11
Polar TM6 Y 299 6x34 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 Y 299 6x34 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 Y 299 6x34 s5s6 G 73 N.s5s6.09
Hydrophobic ICL2 F 199 34x51 s15s16 T 247 C.s15s16.05
Aromatic TM5 Y 292 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 Y 292 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Y 292 5x68 s15s16 F 245 C.s15s16.03
Polar C-term T 373 - S6 D 79 N.S6.04
Van-der-waals C-term T 373 - S6 D 79 N.S6.04
Hydrophobic TM3 R 191 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 191 3x50 s5s6 V 71 N.s5s6.07
Ionic ICL2 R 202 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic C-term T 373 - s15s16 F 245 C.s15s16.03
Van-der-waals C-term T 373 - s15s16 F 245 C.s15s16.03
Hydrophobic C-term A 370 - S6 R 77 N.S6.02
Van-der-waals C-term A 370 - S6 R 77 N.S6.02
Polar C-term T 373 - S6 K 78 N.S6.03
Hydrophobic C-term T 373 - S6 K 78 N.S6.03
Van-der-waals C-term T 373 - S6 K 78 N.S6.03
Polar ICL2 R 202 34x54 S8 L 130 N.S8.03
Hydrophobic ICL2 R 202 34x54 S8 L 130 N.S8.03
Van-der-waals ICL2 R 202 34x54 S8 L 130 N.S8.03
Hydrophobic TM2 T 128 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 T 128 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic C-term L 372 - S6 D 79 N.S6.04
Van-der-waals C-term L 372 - S6 D 79 N.S6.04
Aromatic ICL2 R 202 34x54 S16 Y 250 C.S16.03
Hydrophobic ICL2 R 202 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 R 202 34x54 S16 Y 250 C.S16.03
Hydrophobic TM6 Y 299 6x34 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 Y 299 6x34 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 F 199 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 F 199 34x51 S16 A 248 C.S16.01