Arrestin-C - PAR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
PAR3 75.2
Arrestin-C 82.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 T 128 2x39 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 I 195 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL1 T 123 - s5s6 L 64 N.s5s6.05
Ionic TM4 K 206 4x38 s5s6 E 65 N.s5s6.06
Polar TM4 K 206 4x38 s5s6 E 65 N.s5s6.06
Hydrophobic TM6 W 296 6x31 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 W 296 6x31 s5s6 L 69 N.s5s6.10
Hydrophobic C-term T 373 - S6 F 71 N.S6.01
Polar C-term T 369 - s5s6 G 68 N.s5s6.09
Ionic ICL2 R 202 34x54 S16 D 244 C.S16.01
Polar C-term Y 371 - S6 F 71 N.S6.01
Hydrophobic C-term Y 371 - S6 F 71 N.S6.01
Van-der-waals C-term Y 371 - S6 F 71 N.S6.01
Polar ICL2 Y 201 34x53 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 Y 201 34x53 s5s6 E 65 N.s5s6.06
Van-der-waals ICL2 Y 201 34x53 s5s6 E 65 N.s5s6.06
Polar TM4 K 206 4x38 S5 Y 59 N.S5.12
Van-der-waals TM4 K 206 4x38 S5 Y 59 N.S5.12
Polar ICL1 S 125 - s5s6 E 65 N.s5s6.06
Van-der-waals ICL1 S 125 - s5s6 E 65 N.s5s6.06
Hydrophobic C-term Y 371 - s5s6 L 69 N.s5s6.10
Van-der-waals C-term Y 371 - s5s6 L 69 N.s5s6.10
Hydrophobic C-term L 372 - S6 R 72 N.S6.02
Van-der-waals C-term L 372 - S6 R 72 N.S6.02
Polar C-term T 373 - S6 R 72 N.S6.02
Van-der-waals C-term T 373 - S6 R 72 N.S6.02
Hydrophobic TM2 I 126 2x37 s8s9 A 133 N.s8s9.07
Van-der-waals TM2 I 126 2x37 s8s9 A 133 N.s8s9.07
Hydrophobic TM3 A 194 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 A 194 3x53 S6 F 71 N.S6.01
Polar C-term Y 371 - S6 R 72 N.S6.02
Van-der-waals C-term Y 371 - S6 R 72 N.S6.02
Polar ICL1 S 125 - s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 S 125 - s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 S 125 - s5s6 D 63 N.s5s6.04
Hydrophobic TM3 A 194 3x53 s5s6 E 65 N.s5s6.06
Van-der-waals TM3 A 194 3x53 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 G 203 34x55 s15s16 S 242 C.s15s16.04
Polar C-term Y 371 - s5s6 T 70 N.s5s6.11
Hydrophobic C-term Y 371 - s5s6 T 70 N.s5s6.11
Van-der-waals C-term Y 371 - s5s6 T 70 N.s5s6.11
Hydrophobic ICL2 F 199 34x51 S6 K 73 N.S6.03
Van-der-waals ICL2 F 199 34x51 S6 K 73 N.S6.03
Hydrophobic ICL2 R 202 34x54 S15 V 238 C.S15.14
Van-der-waals ICL2 R 202 34x54 S15 V 238 C.S15.14
Hydrophobic ICL2 R 202 34x54 S5 F 57 N.S5.10
Van-der-waals ICL2 R 202 34x54 S5 F 57 N.S5.10
Hydrophobic ICL2 F 199 34x51 S6 F 71 N.S6.01
Ionic ICL3 D 293 - s9s10 K 157 N.s9s10.12
Polar ICL3 D 293 - s9s10 K 157 N.s9s10.12
Van-der-waals ICL3 D 293 - s9s10 K 157 N.s9s10.12
Aromatic ICL2 F 199 34x51 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 F 199 34x51 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 F 199 34x51 s15s16 Y 241 C.s15s16.03
Polar TM2 C 127 2x38 s5s6 E 65 N.s5s6.06
Hydrophobic TM2 C 127 2x38 s5s6 E 65 N.s5s6.06
Van-der-waals TM2 C 127 2x38 s5s6 E 65 N.s5s6.06
Polar C-term S 368 - s5s6 R 61 N.s5s6.02
Hydrophobic C-term S 368 - s5s6 R 61 N.s5s6.02
Van-der-waals C-term S 368 - s5s6 R 61 N.s5s6.02
Hydrophobic TM6 W 296 6x31 s5s6 G 68 N.s5s6.09
Polar ICL2 R 202 34x54 S9 C 137 N.S9.01
Hydrophobic ICL2 R 202 34x54 S9 C 137 N.S9.01
Van-der-waals ICL2 R 202 34x54 S9 C 137 N.S9.01
Hydrophobic ICL2 P 198 34x50 S6 F 71 N.S6.01
Van-der-waals ICL2 P 198 34x50 S6 F 71 N.S6.01
Polar ICL2 G 203 34x55 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 G 203 34x55 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 G 203 34x55 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 F 199 34x51 S6 R 72 N.S6.02
Van-der-waals ICL2 F 199 34x51 S6 R 72 N.S6.02
Hydrophobic C-term A 370 - s5s6 T 70 N.s5s6.11
Hydrophobic ICL1 S 125 - s5s6 L 64 N.s5s6.05
Van-der-waals TM4 K 206 4x38 s8s9 K 135 N.s8s9.09
Polar C-term T 369 - s5s6 T 70 N.s5s6.11
Van-der-waals C-term T 369 - s5s6 T 70 N.s5s6.11
Hydrophobic ICL2 R 202 34x54 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 R 202 34x54 s15s16 Y 241 C.s15s16.03
Hydrophobic C-term R 365 - s5s6 D 62 N.s5s6.03
Hydrophobic ICL2 F 199 34x51 S5 F 57 N.S5.10
Polar ICL2 R 202 34x54 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 R 202 34x54 s15s16 S 242 C.s15s16.04
Hydrophobic C-term T 364 - s5s6 I 67 N.s5s6.08
Van-der-waals C-term T 364 - s5s6 I 67 N.s5s6.08
Hydrophobic TM3 A 194 3x53 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 I 195 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 195 3x54 s5s6 I 67 N.s5s6.08
Polar TM2 T 128 2x39 s5s6 E 65 N.s5s6.06
Van-der-waals TM2 T 128 2x39 s5s6 E 65 N.s5s6.06
Hydrophobic TM5 L 289 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM7 M 361 7x56 s5s6 L 64 N.s5s6.05
Van-der-waals TM7 M 361 7x56 s5s6 L 64 N.s5s6.05
Polar ICL1 R 124 - s8s9 P 130 N.s8s9.04
Hydrophobic ICL1 R 124 - s8s9 P 130 N.s8s9.04
Van-der-waals ICL1 R 124 - s8s9 P 130 N.s8s9.04
Hydrophobic TM6 Y 299 6x34 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 Y 299 6x34 s5s6 I 67 N.s5s6.08
Hydrophobic C-term S 362 - s5s6 L 64 N.s5s6.05
Van-der-waals C-term S 362 - s5s6 L 64 N.s5s6.05
Hydrophobic TM3 I 195 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 195 3x54 S6 F 71 N.S6.01
Hydrophobic ICL2 R 202 34x54 S5 Y 59 N.S5.12
Van-der-waals ICL2 R 202 34x54 S5 Y 59 N.S5.12