Beta-arrestin-2 - PAR4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
PAR4 71.8
Beta-arrestin-2 78.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 182 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 182 34x51 S16 Y 250 C.S16.03
Polar ICL2 R 183 34x52 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 R 183 34x52 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 R 183 34x52 s8s9 T 137 N.s8s9.07
Polar TM2 S 111 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 111 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 111 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 L 178 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 L 178 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 R 185 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 185 34x54 s5s6 R 66 N.s5s6.02
Aromatic TM6 Y 278 6x31 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 Y 278 6x31 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 Y 278 6x31 s15s16 F 245 C.s15s16.03
Hydrophobic TM2 L 115 2x43 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 L 115 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 L 178 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 L 178 3x54 S6 F 76 N.S6.01
Hydrophobic H8 S 344 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 R 188 34x57 s5s6 L 69 N.s5s6.05
Van-der-waals ICL2 R 188 34x57 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 A 177 3x53 S6 F 76 N.S6.01
Polar ICL2 R 185 34x54 s8s9 P 132 N.s8s9.02
Hydrophobic ICL2 R 185 34x54 s8s9 P 132 N.s8s9.02
Van-der-waals ICL2 R 185 34x54 s8s9 P 132 N.s8s9.02
Hydrophobic TM3 R 174 3x50 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 L 182 34x51 S15 I 242 C.S15.14
Ionic ICL3 R 277 - S6 D 79 N.S6.04
Polar ICL3 R 277 - S6 D 79 N.S6.04
Hydrophobic ICL3 R 277 - S6 D 79 N.S6.04
Van-der-waals ICL3 R 277 - S6 D 79 N.S6.04
Hydrophobic TM6 L 284 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 284 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM7 V 343 7x56 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 A 177 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 177 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM2 L 115 2x43 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 P 181 34x50 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 P 181 34x50 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 L 284 6x37 s5s6 G 73 N.s5s6.09
Hydrophobic TM2 L 109 2x37 s5s6 E 67 N.s5s6.03
Polar ICL2 P 181 34x50 s8s9 K 139 N.s8s9.09
Hydrophobic ICL2 P 181 34x50 s8s9 K 139 N.s8s9.09
Polar ICL2 R 185 34x54 s8s9 G 133 N.s8s9.03
Van-der-waals ICL2 R 185 34x54 s8s9 G 133 N.s8s9.03
Hydrophobic ICL2 P 181 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 181 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 L 182 34x51 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 L 182 34x51 s15s16 T 247 C.s15s16.05
Hydrophobic TM2 L 109 2x37 s5s6 R 66 N.s5s6.02
Polar ICL2 P 181 34x50 s8s9 G 138 N.s8s9.08
Hydrophobic ICL2 P 181 34x50 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 P 181 34x50 s8s9 G 138 N.s8s9.08
Hydrophobic TM7 Y 340 7x53 s5s6 L 72 N.s5s6.08
Polar ICL2 R 185 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 R 185 34x54 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 R 185 34x54 s8s9 T 137 N.s8s9.07
Polar ICL2 P 181 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 181 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 181 34x50 S5 Y 64 N.S5.12
Hydrophobic TM6 A 281 6x34 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 281 6x34 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 R 185 34x54 s8s9 K 139 N.s8s9.09
Polar ICL2 R 185 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 R 185 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 R 185 34x54 s8s9 D 136 N.s8s9.06
Polar TM3 A 177 3x53 s8s9 K 139 N.s8s9.09
Hydrophobic TM3 A 177 3x53 s8s9 K 139 N.s8s9.09
Van-der-waals TM3 A 177 3x53 s8s9 K 139 N.s8s9.09
Hydrophobic TM5 L 271 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 V 170 3x46 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 182 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 182 34x51 S16 A 248 C.S16.01
Hydrophobic ICL3 R 277 - S6 K 78 N.S6.03
Van-der-waals ICL3 R 277 - S6 K 78 N.S6.03
Ionic H8 D 349 8x52 s9s10 K 161 N.s9s10.12
Polar H8 D 349 8x52 s9s10 K 161 N.s9s10.12
Hydrophobic H8 D 349 8x52 s9s10 K 161 N.s9s10.12
Van-der-waals H8 D 349 8x52 s9s10 K 161 N.s9s10.12
Hydrophobic TM2 L 109 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 L 109 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 A 186 34x55 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 A 186 34x55 s8s9 T 137 N.s8s9.07
Hydrophobic TM2 S 111 2x39 s5s6 L 72 N.s5s6.08
Polar ICL2 A 184 34x53 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 A 184 34x53 s8s9 T 137 N.s8s9.07
Polar ICL3 R 277 - S6 R 77 N.S6.02
Hydrophobic ICL3 R 277 - S6 R 77 N.S6.02
Van-der-waals ICL3 R 277 - S6 R 77 N.S6.02
Polar ICL2 R 185 34x54 s8s9 G 138 N.s8s9.08
Hydrophobic ICL2 R 185 34x54 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 R 185 34x54 s8s9 G 138 N.s8s9.08
Polar TM6 H 280 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM7 Y 340 7x53 s5s6 V 71 N.s5s6.07
Polar H8 S 344 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic H8 S 344 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 S 344 8x47 s5s6 D 70 N.s5s6.06
Polar ICL1 R 108 - s20c Y 404 C.s20c.14
Van-der-waals ICL1 R 108 - s20c Y 404 C.s20c.14
Ionic ICL2 R 188 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 188 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 188 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 188 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 L 182 34x51 s8s9 G 138 N.s8s9.08
Polar ICL2 L 182 34x51 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 L 182 34x51 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 L 182 34x51 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 L 182 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 L 182 34x51 s15s16 S 246 C.s15s16.04
Polar ICL2 R 188 34x57 s5s6 R 66 N.s5s6.02
Polar TM3 R 174 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 174 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 174 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 P 107 - s20c Y 404 C.s20c.14
Van-der-waals ICL1 P 107 - s20c Y 404 C.s20c.14