ArrestinDb

Arrestin-C - PAR4 complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
PAR4	72.6
Arrestin-C	79.8

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.4

PAE mean: 21.1

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	TM3	A	177	3x53	s15s16	Y	241	C.s15s16.03
Hydrophobic	H8	S	344	8x47	s5s6	E	65	N.s5s6.06
Hydrophobic	ICL1	P	107	-	s5s6	D	62	N.s5s6.03
Hydrophobic	TM6	A	281	6x34	s5s6	L	69	N.s5s6.10
Hydrophobic	TM2	L	109	2x37	s5s6	D	63	N.s5s6.04
Hydrophobic	ICL2	R	185	34x54	s15s16	L	243	C.s15s16.05
Hydrophobic	TM2	L	115	2x43	s5s6	V	66	N.s5s6.07
Hydrophobic	ICL2	L	182	34x51	s15s16	L	243	C.s15s16.05
Hydrophobic	TM5	L	271	5x65	s5s6	L	69	N.s5s6.10
Hydrophobic	TM3	R	174	3x50	s5s6	I	67	N.s5s6.08
Hydrophobic	TM3	L	178	3x54	s5s6	L	69	N.s5s6.10
Hydrophobic	ICL2	L	182	34x51	s15s16	L	240	C.s15s16.02
Hydrophobic	ICL2	R	185	34x54	S15	V	238	C.S15.14
Hydrophobic	TM3	L	178	3x54	s5s6	L	64	N.s5s6.05
Hydrophobic	TM3	L	178	3x54	S6	F	71	N.S6.01
Hydrophobic	TM7	Y	340	7x53	s5s6	V	66	N.s5s6.07
Hydrophobic	ICL2	L	182	34x51	s17s18	E	310	C.s17s18.39
Hydrophobic	TM6	L	284	6x37	s5s6	I	67	N.s5s6.08
Hydrophobic	TM7	Y	341	7x54	s5s6	V	66	N.s5s6.07
Hydrophobic	ICL2	P	181	34x50	s15s16	Y	241	C.s15s16.03
Hydrophobic	ICL2	R	185	34x54	S16	D	244	C.S16.01
Hydrophobic	ICL2	L	182	34x51	s15s16	V	239	C.s15s16.01
Hydrophobic	ICL2	P	181	34x50	S6	F	71	N.S6.01
Hydrophobic	TM3	L	178	3x54	s15s16	Y	241	C.s15s16.03
Hydrophobic	ICL2	R	185	34x54	s15s16	Y	241	C.s15s16.03
Hydrophobic	TM2	L	109	2x37	s8s9	A	133	N.s8s9.07
Hydrophobic	ICL3	R	276	-	s9s10	T	154	N.s9s10.09
Hydrophobic	ICL2	L	182	34x51	s15s16	Y	241	C.s15s16.03
Hydrophobic	TM2	L	109	2x37	s8s9	K	135	N.s8s9.09
Hydrophobic	H8	S	344	8x47	s5s6	V	66	N.s5s6.07
Hydrophobic	H8	E	346	8x49	s5s6	E	65	N.s5s6.06
Hydrophobic	ICL2	R	188	34x57	s5s6	D	63	N.s5s6.04
Hydrophobic	TM6	Y	278	6x31	S6	R	72	N.S6.02
Hydrophobic	TM2	S	111	2x39	s5s6	D	63	N.s5s6.04
Hydrophobic	ICL2	R	188	34x57	s5s6	R	61	N.s5s6.02
Hydrophobic	ICL3	R	277	-	S6	R	72	N.S6.02
Hydrophobic	ICL2	R	185	34x54	s15s16	S	242	C.s15s16.04
Hydrophobic	TM6	H	280	6x33	s5s6	G	68	N.s5s6.09
Hydrophobic	TM6	Y	278	6x31	s5s6	L	69	N.s5s6.10
Hydrophobic	TM2	L	109	2x37	s5s6	D	62	N.s5s6.03
Ionic	ICL3	R	277	-	S6	D	74	N.S6.04
Ionic	ICL2	R	185	34x54	S16	D	244	C.S16.01
Ionic	ICL2	R	188	34x57	s5s6	D	63	N.s5s6.04
Polar	ICL2	P	181	34x50	s15s16	S	242	C.s15s16.04
Polar	H8	S	344	8x47	s5s6	E	65	N.s5s6.06
Polar	ICL3	R	277	-	S6	D	74	N.S6.04
Polar	ICL2	R	185	34x54	s15s16	L	243	C.s15s16.05
Polar	ICL2	R	185	34x54	S15	V	238	C.S15.14
Polar	ICL2	P	181	34x50	s15s16	Y	241	C.s15s16.03
Polar	ICL2	R	185	34x54	S16	D	244	C.S16.01
Polar	TM6	Y	278	6x31	S6	K	73	N.S6.03
Polar	ICL3	R	276	-	s9s10	T	154	N.s9s10.09
Polar	ICL2	L	182	34x51	s15s16	Y	241	C.s15s16.03
Polar	ICL2	R	188	34x57	s5s6	D	63	N.s5s6.04
Polar	TM6	Y	278	6x31	S6	R	72	N.S6.02
Polar	TM2	S	111	2x39	s5s6	D	63	N.s5s6.04
Polar	ICL2	R	185	34x54	s15s16	S	242	C.s15s16.04
Van-der-waals	TM3	A	177	3x53	s15s16	Y	241	C.s15s16.03
Van-der-waals	H8	S	344	8x47	s5s6	E	65	N.s5s6.06
Van-der-waals	ICL1	P	107	-	s5s6	D	62	N.s5s6.03
Van-der-waals	TM6	A	281	6x34	s5s6	L	69	N.s5s6.10
Van-der-waals	TM2	L	109	2x37	s5s6	D	63	N.s5s6.04
Van-der-waals	ICL2	R	185	34x54	s15s16	L	243	C.s15s16.05
Van-der-waals	ICL2	L	182	34x51	s15s16	L	243	C.s15s16.05
Van-der-waals	TM5	L	271	5x65	s5s6	L	69	N.s5s6.10
Van-der-waals	TM3	R	174	3x50	s5s6	I	67	N.s5s6.08
Van-der-waals	ICL2	L	182	34x51	s15s16	L	240	C.s15s16.02
Van-der-waals	ICL2	R	185	34x54	S15	V	238	C.S15.14
Van-der-waals	TM3	L	178	3x54	s5s6	L	64	N.s5s6.05
Van-der-waals	TM7	Y	340	7x53	s5s6	V	66	N.s5s6.07
Van-der-waals	ICL2	L	182	34x51	s17s18	E	310	C.s17s18.39
Van-der-waals	TM6	L	284	6x37	s5s6	I	67	N.s5s6.08
Van-der-waals	ICL2	P	181	34x50	s15s16	Y	241	C.s15s16.03
Van-der-waals	ICL2	R	185	34x54	S16	D	244	C.S16.01
Van-der-waals	ICL2	L	182	34x51	s15s16	V	239	C.s15s16.01
Van-der-waals	ICL2	R	185	34x54	s5s6	R	61	N.s5s6.02
Van-der-waals	TM2	L	109	2x37	s8s9	A	133	N.s8s9.07
Van-der-waals	ICL3	R	276	-	s9s10	T	154	N.s9s10.09
Van-der-waals	ICL2	L	182	34x51	s15s16	Y	241	C.s15s16.03
Van-der-waals	TM2	L	109	2x37	s8s9	K	135	N.s8s9.09
Van-der-waals	H8	E	346	8x49	s5s6	E	65	N.s5s6.06
Van-der-waals	ICL2	R	188	34x57	s5s6	D	63	N.s5s6.04
Van-der-waals	TM6	Y	278	6x31	S6	R	72	N.S6.02
Van-der-waals	TM2	S	111	2x39	s5s6	D	63	N.s5s6.04
Van-der-waals	ICL2	R	188	34x57	s5s6	R	61	N.s5s6.02
Van-der-waals	ICL3	R	277	-	S6	R	72	N.S6.02
Van-der-waals	ICL2	R	185	34x54	s15s16	S	242	C.s15s16.04
Van-der-waals	TM6	Y	278	6x31	s5s6	L	69	N.s5s6.10
Van-der-waals	TM2	L	109	2x37	s5s6	D	62	N.s5s6.03

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Arrestin-C - PAR4 complex model Download Full