Beta-arrestin-1 - DP2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
DP2 72.6
Beta-arrestin-1 80.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic H8 C 308 8x47 s5s6 L 71 N.s5s6.08
Van-der-waals H8 C 308 8x47 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 L 247 6x36 s5s6 L 71 N.s5s6.08
Polar TM3 Q 132 3x53 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 Q 132 3x53 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 Q 132 3x53 s15s16 N 245 C.s15s16.04
Polar TM5 R 236 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 R 236 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 236 5x68 s15s16 F 244 C.s15s16.03
Polar TM5 R 236 5x68 s15s16 T 246 C.s15s16.05
Hydrophobic TM5 R 236 5x68 s15s16 T 246 C.s15s16.05
Van-der-waals TM5 R 236 5x68 s15s16 T 246 C.s15s16.05
Polar TM6 R 243 6x32 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 R 243 6x32 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 R 243 6x32 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 233 5x65 S6 F 75 N.S6.01
Hydrophobic TM2 V 66 2x39 s5s6 L 73 N.s5s6.10
Ionic TM6 R 243 6x32 s5s6 D 69 N.s5s6.06
Polar TM6 R 243 6x32 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 R 243 6x32 s5s6 D 69 N.s5s6.06
Van-der-waals TM6 R 243 6x32 s5s6 D 69 N.s5s6.06
Hydrophobic ICL1 R 62 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL1 R 62 - s5s6 R 65 N.s5s6.02
Hydrophobic TM3 V 133 3x54 s15s16 F 244 C.s15s16.03
Hydrophobic TM2 V 66 2x39 s5s6 L 71 N.s5s6.08
Polar ICL2 Q 140 34x54 S16 Y 249 C.S16.03
Hydrophobic ICL2 Q 140 34x54 S16 Y 249 C.S16.03
Van-der-waals ICL2 Q 140 34x54 S16 Y 249 C.S16.03
Hydrophobic ICL3 R 238 - S6 K 77 N.S6.03
Van-der-waals ICL3 R 238 - S6 K 77 N.S6.03
Hydrophobic ICL2 P 136 34x50 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 P 136 34x50 s15s16 T 246 C.s15s16.05
Hydrophobic TM6 R 243 6x32 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 R 243 6x32 s5s6 G 72 N.s5s6.09
Polar H8 D 310 8x49 s5s6 V 70 N.s5s6.07
Hydrophobic H8 D 310 8x49 s5s6 V 70 N.s5s6.07
Van-der-waals H8 D 310 8x49 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 R 243 6x32 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 R 243 6x32 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 T 64 2x37 s5s6 R 65 N.s5s6.02
Van-der-waals TM2 T 64 2x37 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 V 137 34x51 S16 A 247 C.S16.01
Polar ICL2 P 136 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 P 136 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 136 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic H8 P 309 8x48 s5s6 V 70 N.s5s6.07
Hydrophobic TM4 T 144 4x38 s8s9 T 136 N.s8s9.07
Ionic H8 R 317 8x56 s20c E 407 C.s20c.17
Polar H8 R 317 8x56 s20c E 407 C.s20c.17
Hydrophobic H8 R 317 8x56 s20c E 407 C.s20c.17
Van-der-waals H8 R 317 8x56 s20c E 407 C.s20c.17
Polar TM3 V 133 3x54 s15s16 N 245 C.s15s16.04
Polar TM6 F 244 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 F 244 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 F 244 6x33 s5s6 L 71 N.s5s6.08
Polar ICL3 R 238 - S6 R 76 N.S6.02
Hydrophobic ICL3 R 238 - S6 R 76 N.S6.02
Van-der-waals ICL3 R 238 - S6 R 76 N.S6.02
Hydrophobic ICL2 N 141 34x55 s8s9 T 136 N.s8s9.07
Polar ICL2 Q 140 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 Q 140 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 Q 140 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 R 236 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 R 236 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 L 233 5x65 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 G 242 6x31 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 G 242 6x31 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 H 142 34x56 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 Q 140 34x54 S16 A 247 C.S16.01
Hydrophobic TM6 F 244 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 P 136 34x50 S16 A 247 C.S16.01
Hydrophobic H8 M 311 8x50 s5s6 V 70 N.s5s6.07
Van-der-waals H8 M 311 8x50 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 V 137 34x51 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 V 137 34x51 s15s16 T 246 C.s15s16.05
Polar H8 C 308 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic H8 C 308 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 C 308 8x47 s5s6 V 70 N.s5s6.07
Polar ICL2 Q 140 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 Q 140 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 Q 140 34x54 s8s9 G 137 N.s8s9.08
Polar ICL2 R 143 34x57 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 R 143 34x57 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 143 34x57 s8s9 T 136 N.s8s9.07
Polar ICL2 Q 140 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 Q 140 34x54 s8s9 D 135 N.s8s9.06
Ionic H8 K 314 8x53 s20c E 404 C.s20c.14
Polar ICL2 A 139 34x53 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 A 139 34x53 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 A 139 34x53 s8s9 T 136 N.s8s9.07
Van-der-waals ICL3 R 238 - s15s16 F 244 C.s15s16.03
Polar ICL3 R 238 - S6 F 75 N.S6.01
Aromatic ICL3 R 238 - S6 F 75 N.S6.01
Hydrophobic ICL3 R 238 - S6 F 75 N.S6.01
Van-der-waals ICL3 R 238 - S6 F 75 N.S6.01