Beta-arrestin-2 - DP2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
DP2 74.0
Beta-arrestin-2 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 17.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM6 V 245 6x34 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 V 245 6x34 s5s6 V 71 N.s5s6.07
Polar ICL2 Q 140 34x54 s8s9 Q 131 N.s8s9.01
Van-der-waals ICL2 Q 140 34x54 s8s9 Q 131 N.s8s9.01
Polar H8 K 314 8x53 s20c C 409 C.s20c.19
Hydrophobic H8 K 314 8x53 s20c C 409 C.s20c.19
Van-der-waals H8 K 314 8x53 s20c C 409 C.s20c.19
Polar TM4 V 145 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 V 145 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 V 145 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 L 233 5x65 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 L 233 5x65 s15s16 F 245 C.s15s16.03
Polar TM5 R 236 5x68 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 R 236 5x68 s15s16 S 246 C.s15s16.04
Van-der-waals TM5 R 236 5x68 s15s16 S 246 C.s15s16.04
Polar TM5 R 232 5x64 s15s16 T 247 C.s15s16.05
Polar H8 R 313 8x52 s20c L 408 C.s20c.18
Hydrophobic H8 R 313 8x52 s20c L 408 C.s20c.18
Van-der-waals H8 R 313 8x52 s20c L 408 C.s20c.18
Hydrophobic ICL2 Q 140 34x54 s17s18 G 287 C.s17s18.12
Van-der-waals ICL2 Q 140 34x54 s17s18 G 287 C.s17s18.12
Hydrophobic TM6 V 245 6x34 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 245 6x34 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 F 244 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 F 244 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 V 66 2x39 s5s6 L 69 N.s5s6.05
Van-der-waals TM2 V 66 2x39 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 V 137 34x51 S16 A 248 C.S16.01
Polar ICL2 Q 140 34x54 S16 Y 250 C.S16.03
Hydrophobic ICL2 Q 140 34x54 S16 Y 250 C.S16.03
Van-der-waals ICL2 Q 140 34x54 S16 Y 250 C.S16.03
Hydrophobic TM2 V 66 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 V 66 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 V 229 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 R 236 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 R 236 5x68 S6 F 76 N.S6.01
Hydrophobic TM6 V 245 6x34 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 V 245 6x34 s5s6 G 73 N.s5s6.09
Hydrophobic H8 D 310 8x49 s20c C 409 C.s20c.19
Van-der-waals H8 D 310 8x49 s20c C 409 C.s20c.19
Ionic H8 R 317 8x56 s20c D 406 C.s20c.16
Polar H8 R 317 8x56 s20c D 406 C.s20c.16
Hydrophobic ICL2 P 136 34x50 s15s16 S 246 C.s15s16.04
Polar TM6 R 243 6x32 s5s6 D 70 N.s5s6.06
Polar TM6 R 243 6x32 s20c C 409 C.s20c.19
Hydrophobic TM6 R 243 6x32 s20c C 409 C.s20c.19
Van-der-waals TM6 R 243 6x32 s20c C 409 C.s20c.19
Polar ICL2 P 136 34x50 S16 Y 250 C.S16.03
Polar ICL2 Q 140 34x54 s17s18 R 286 C.s17s18.11
Hydrophobic H8 D 310 8x49 s20c L 408 C.s20c.18
Van-der-waals H8 D 310 8x49 s20c L 408 C.s20c.18
Hydrophobic TM2 T 64 2x37 s5s6 L 69 N.s5s6.05
Van-der-waals TM2 T 64 2x37 s5s6 L 69 N.s5s6.05
Ionic ICL1 R 62 - s20c D 402 C.s20c.12
Polar ICL1 R 62 - s20c D 402 C.s20c.12
Van-der-waals ICL1 R 62 - s20c D 402 C.s20c.12
Polar TM6 F 244 6x33 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 F 244 6x33 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 F 244 6x33 s5s6 V 71 N.s5s6.07
Polar TM3 R 129 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 129 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 129 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 Q 140 34x54 S8 L 130 N.S8.03
Van-der-waals ICL2 Q 140 34x54 S8 L 130 N.S8.03
Hydrophobic TM4 T 144 4x38 s17s18 R 286 C.s17s18.11
Hydrophobic TM5 L 233 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 233 5x65 s5s6 L 74 N.s5s6.10
Polar TM5 R 236 5x68 s15s16 F 245 C.s15s16.03
Aromatic TM5 R 236 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 236 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 236 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 P 136 34x50 S5 Y 64 N.S5.12
Polar ICL1 R 62 - s8s9 P 134 N.s8s9.04
Van-der-waals ICL1 R 62 - s8s9 P 134 N.s8s9.04
Polar TM6 G 242 6x31 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 G 242 6x31 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 G 242 6x31 s5s6 G 73 N.s5s6.09
Polar H8 R 313 8x52 s20c D 406 C.s20c.16
Van-der-waals H8 R 313 8x52 s20c D 406 C.s20c.16
Hydrophobic ICL2 P 136 34x50 S16 A 248 C.S16.01
Polar ICL3 R 239 - s5s6 S 75 N.s5s6.11
Hydrophobic ICL3 R 239 - s5s6 S 75 N.s5s6.11
Van-der-waals ICL3 R 239 - s5s6 S 75 N.s5s6.11
Hydrophobic TM3 Q 132 3x53 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 Q 132 3x53 s5s6 L 72 N.s5s6.08
Hydrophobic TM4 T 144 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 T 144 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic ICL1 R 62 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 R 62 - s8s9 T 137 N.s8s9.07
Aromatic ICL3 R 239 - S6 F 76 N.S6.01
Hydrophobic ICL3 R 239 - S6 F 76 N.S6.01
Van-der-waals ICL3 R 239 - S6 F 76 N.S6.01
Hydrophobic TM3 Q 132 3x53 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 Q 132 3x53 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 V 137 34x51 S16 Q 249 C.S16.02
Polar ICL2 V 137 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 V 137 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 V 137 34x51 S16 Y 250 C.S16.03
Polar ICL3 R 239 - S6 R 77 N.S6.02
Hydrophobic ICL3 R 239 - S6 R 77 N.S6.02
Van-der-waals ICL3 R 239 - S6 R 77 N.S6.02
Hydrophobic TM3 V 133 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 V 133 3x54 s5s6 L 74 N.s5s6.10