Arrestin-C - DP2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
DP2 72.2
Arrestin-C 79.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM6 F 244 6x33 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 G 242 6x31 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 G 242 6x31 s5s6 G 68 N.s5s6.09
Hydrophobic H8 C 308 8x47 s5s6 I 67 N.s5s6.08
Van-der-waals H8 C 308 8x47 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 R 236 5x68 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 R 236 5x68 s15s16 L 240 C.s15s16.02
Hydrophobic TM6 R 243 6x32 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 V 66 2x39 s5s6 L 69 N.s5s6.10
Van-der-waals TM2 V 66 2x39 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 P 136 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 136 34x50 s15s16 S 242 C.s15s16.04
Polar ICL2 Q 140 34x54 S5 Y 59 N.S5.12
Hydrophobic ICL2 Q 140 34x54 S5 Y 59 N.S5.12
Van-der-waals ICL2 Q 140 34x54 S5 Y 59 N.S5.12
Polar TM6 R 243 6x32 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 R 243 6x32 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 V 137 34x51 s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 V 137 34x51 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 P 136 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 136 34x50 s15s16 Y 241 C.s15s16.03
Polar ICL2 Q 140 34x54 S16 Y 246 C.S16.03
Hydrophobic ICL2 Q 140 34x54 S16 Y 246 C.S16.03
Van-der-waals ICL2 Q 140 34x54 S16 Y 246 C.S16.03
Hydrophobic ICL2 V 137 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 V 137 34x51 S16 D 244 C.S16.01
Hydrophobic TM3 V 133 3x54 S6 F 71 N.S6.01
Polar ICL2 Q 140 34x54 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 Q 140 34x54 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 Q 140 34x54 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 N 141 34x55 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 N 141 34x55 s8s9 A 133 N.s8s9.07
Polar TM6 R 243 6x32 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 R 243 6x32 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 R 243 6x32 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 Q 140 34x54 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 Q 140 34x54 s8s9 G 134 N.s8s9.08
Ionic TM5 R 232 5x64 s17s18 E 310 C.s17s18.39
Polar TM5 R 232 5x64 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 R 232 5x64 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 R 232 5x64 s17s18 E 310 C.s17s18.39
Hydrophobic TM6 F 244 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 F 244 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic H8 D 310 8x49 s5s6 V 66 N.s5s6.07
Van-der-waals H8 D 310 8x49 s5s6 V 66 N.s5s6.07
Ionic TM5 R 236 5x68 s17s18 E 310 C.s17s18.39
Polar TM5 R 236 5x68 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 R 236 5x68 s17s18 E 310 C.s17s18.39
Hydrophobic ICL3 R 240 - s9s10 T 154 N.s9s10.09
Van-der-waals ICL3 R 240 - s9s10 T 154 N.s9s10.09
Polar TM6 F 244 6x33 s5s6 I 67 N.s5s6.08
Polar H8 D 310 8x49 s5s6 I 67 N.s5s6.08
Hydrophobic H8 D 310 8x49 s5s6 I 67 N.s5s6.08
Van-der-waals H8 D 310 8x49 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 R 236 5x68 S6 K 73 N.S6.03
Van-der-waals TM5 R 236 5x68 S6 K 73 N.S6.03
Polar ICL3 R 239 - S6 R 72 N.S6.02
Hydrophobic ICL3 R 239 - S6 R 72 N.S6.02
Van-der-waals ICL3 R 239 - S6 R 72 N.S6.02
Aromatic TM5 R 236 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 P 136 34x50 s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 V 137 34x51 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 V 137 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic ICL1 R 62 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL1 R 62 - s5s6 R 61 N.s5s6.02
Polar ICL2 N 141 34x55 S16 D 244 C.S16.01
Hydrophobic ICL2 N 141 34x55 S16 D 244 C.S16.01
Van-der-waals ICL2 N 141 34x55 S16 D 244 C.S16.01
Polar ICL2 Q 140 34x54 S16 D 244 C.S16.01
Hydrophobic ICL2 Q 140 34x54 S16 D 244 C.S16.01
Van-der-waals ICL2 Q 140 34x54 S16 D 244 C.S16.01
Ionic ICL3 R 239 - S6 D 74 N.S6.04
Polar ICL3 R 239 - S6 D 74 N.S6.04
Hydrophobic ICL3 R 239 - S6 D 74 N.S6.04
Van-der-waals ICL3 R 239 - S6 D 74 N.S6.04
Hydrophobic ICL3 R 239 - S6 K 73 N.S6.03
Van-der-waals ICL3 R 239 - S6 K 73 N.S6.03
Hydrophobic TM3 Q 132 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 Q 132 3x53 S6 F 71 N.S6.01
Polar ICL2 Q 140 34x54 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 Q 140 34x54 s8s9 K 135 N.s8s9.09
Hydrophobic TM5 L 233 5x65 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 Q 140 34x54 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 Q 140 34x54 s8s9 A 133 N.s8s9.07