Beta-arrestin-1 - DP1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
DP1 78.1
Beta-arrestin-1 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 S 133 3x53 s5s6 L 68 N.s5s6.05
Polar TM6 H 263 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic ICL1 P 56 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL1 P 56 - s5s6 D 67 N.s5s6.04
Hydrophobic TM6 L 266 6x36 s5s6 L 71 N.s5s6.08
Polar ICL2 R 141 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 R 141 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 R 141 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL1 R 52 - s9s10 R 161 N.s9s10.13
Polar ICL2 R 141 34x54 s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 R 141 34x54 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 R 141 34x54 s8s9 K 138 N.s8s9.09
Hydrophobic ICL2 Y 140 34x53 s5s6 L 68 N.s5s6.05
Van-der-waals ICL2 Y 140 34x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 M 228 5x66 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 M 228 5x66 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 E 259 6x29 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 L 232 5x70 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 L 232 5x70 s15s16 F 244 C.s15s16.03
Ionic TM5 H 235 5x73 s17s18 E 313 C.s17s18.39
Polar TM5 H 235 5x73 s17s18 E 313 C.s17s18.39
Hydrophobic TM5 H 235 5x73 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 H 235 5x73 s17s18 E 313 C.s17s18.39
Hydrophobic TM3 C 130 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 C 130 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 F 138 34x51 S8 L 129 N.S8.03
Hydrophobic ICL2 F 138 34x51 s8s9 P 131 N.s8s9.02
Van-der-waals ICL2 F 138 34x51 s8s9 P 131 N.s8s9.02
Polar ICL2 H 143 34x56 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 L 54 - s20c K 403 C.s20c.13
Van-der-waals ICL1 L 54 - s20c K 403 C.s20c.13
Hydrophobic TM5 L 232 5x70 s15s16 L 243 C.s15s16.02
Van-der-waals TM5 L 232 5x70 s15s16 L 243 C.s15s16.02
Polar TM5 R 231 5x69 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 231 5x69 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 E 260 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 F 138 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 F 138 34x51 S15 I 241 C.S15.14
Hydrophobic TM3 C 130 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 E 260 6x30 s15s16 F 244 C.s15s16.03
Van-der-waals TM6 E 260 6x30 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 E 129 3x49 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 E 129 3x49 s5s6 V 70 N.s5s6.07
Aromatic ICL2 F 138 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 F 138 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 F 138 34x51 S16 Y 249 C.S16.03
Hydrophobic TM5 M 228 5x66 S6 F 75 N.S6.01
Van-der-waals TM5 M 228 5x66 S6 F 75 N.S6.01
Hydrophobic H8 R 327 8x47 s5s6 L 71 N.s5s6.08
Van-der-waals H8 R 327 8x47 s5s6 L 71 N.s5s6.08
Ionic ICL3 R 251 - s9s10 E 155 N.s9s10.07
Polar ICL3 R 251 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL2 F 138 34x51 S16 A 247 C.S16.01
Polar ICL1 R 52 - s9s10 K 160 N.s9s10.12
Hydrophobic ICL1 R 52 - s9s10 K 160 N.s9s10.12
Van-der-waals ICL1 R 52 - s9s10 K 160 N.s9s10.12
Hydrophobic ICL2 F 138 34x51 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 F 138 34x51 s8s9 D 135 N.s8s9.06
Hydrophobic TM6 H 263 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 H 263 6x33 s5s6 L 73 N.s5s6.10
Polar H8 R 332 8x52 s5s6 L 71 N.s5s6.08
Polar TM3 L 134 3x54 S5 Y 63 N.S5.12
Hydrophobic TM3 S 133 3x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 L 225 5x63 s5s6 L 73 N.s5s6.10
Ionic ICL2 R 142 34x55 s8s9 D 135 N.s8s9.06
Polar ICL2 R 142 34x55 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 R 142 34x55 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 142 34x55 s8s9 D 135 N.s8s9.06
Hydrophobic TM5 L 225 5x63 S6 F 75 N.S6.01
Van-der-waals TM5 L 225 5x63 S6 F 75 N.S6.01
Polar TM4 T 145 4x38 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 R 141 34x54 s8s9 A 139 N.s8s9.10
Van-der-waals ICL2 R 141 34x54 s8s9 A 139 N.s8s9.10
Polar TM5 H 235 5x73 s17s18 N 311 C.s17s18.37
Hydrophobic TM5 H 235 5x73 s17s18 N 311 C.s17s18.37
Van-der-waals TM5 H 235 5x73 s17s18 N 311 C.s17s18.37
Polar ICL2 I 144 34x57 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 I 144 34x57 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 I 144 34x57 s8s9 T 136 N.s8s9.07
Polar TM5 L 232 5x70 S6 K 77 N.S6.03
Hydrophobic TM5 L 232 5x70 S6 K 77 N.S6.03
Van-der-waals TM5 L 232 5x70 S6 K 77 N.S6.03
Polar ICL1 L 54 - s20c E 405 C.s20c.15
Hydrophobic ICL1 L 54 - s20c E 405 C.s20c.15
Van-der-waals ICL1 L 54 - s20c E 405 C.s20c.15
Hydrophobic ICL2 R 141 34x54 s8s9 P 131 N.s8s9.02
Van-der-waals ICL2 R 141 34x54 s8s9 P 131 N.s8s9.02
Polar ICL2 R 141 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 R 141 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 141 34x54 s8s9 T 136 N.s8s9.07
Polar H8 R 332 8x52 s5s6 G 72 N.s5s6.09
Hydrophobic H8 R 332 8x52 s5s6 G 72 N.s5s6.09
Van-der-waals H8 R 332 8x52 s5s6 G 72 N.s5s6.09
Polar TM5 R 231 5x69 s15s16 T 246 C.s15s16.05
Hydrophobic TM5 R 231 5x69 s15s16 T 246 C.s15s16.05
Van-der-waals TM5 R 231 5x69 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 F 138 34x51 S9 C 140 N.S9.01
Hydrophobic ICL2 P 137 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 137 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 137 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 137 34x50 s15s16 N 245 C.s15s16.04
Ionic ICL2 R 142 34x55 s8s9 E 134 N.s8s9.05
Polar ICL2 R 142 34x55 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 142 34x55 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 R 142 34x55 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 Y 140 34x53 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 Y 140 34x53 s8s9 G 137 N.s8s9.08
Polar TM6 H 263 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 H 263 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 H 263 6x33 s5s6 L 71 N.s5s6.08
Polar TM6 E 259 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 E 259 6x29 s5s6 T 74 N.s5s6.11
Polar TM5 H 235 5x73 S6 K 77 N.S6.03
Ionic ICL2 H 143 34x56 s8s9 E 134 N.s8s9.05
Polar ICL2 H 143 34x56 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 H 143 34x56 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 H 143 34x56 s8s9 E 134 N.s8s9.05
Hydrophobic TM6 E 260 6x30 S6 F 75 N.S6.01
Van-der-waals TM6 E 260 6x30 S6 F 75 N.S6.01
Polar ICL2 R 141 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 R 141 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 141 34x54 s8s9 D 135 N.s8s9.06
Polar H8 R 327 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 R 327 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 R 141 34x54 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 R 141 34x54 s8s9 E 134 N.s8s9.05
Hydrophobic ICL1 L 54 - s20c E 404 C.s20c.14
Van-der-waals ICL1 L 54 - s20c E 404 C.s20c.14
Hydrophobic TM2 F 61 2x39 s5s6 D 69 N.s5s6.06
Van-der-waals TM2 F 61 2x39 s5s6 D 69 N.s5s6.06
Polar ICL2 Y 140 34x53 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 Y 140 34x53 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 Y 140 34x53 s8s9 T 136 N.s8s9.07
Polar ICL1 P 53 - s20c E 405 C.s20c.15
Hydrophobic ICL1 P 53 - s20c E 405 C.s20c.15
Van-der-waals ICL1 P 53 - s20c E 405 C.s20c.15
Hydrophobic TM3 L 134 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 L 134 3x54 S6 F 75 N.S6.01
Polar TM3 G 135 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 G 135 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 H 235 5x73 s17s18 I 314 C.s17s18.40
Hydrophobic TM2 F 61 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 F 61 2x39 s5s6 V 70 N.s5s6.07
Polar TM3 L 134 3x54 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 L 134 3x54 s15s16 N 245 C.s15s16.04
Polar TM2 S 59 2x37 s5s6 D 69 N.s5s6.06
Hydrophobic TM2 S 59 2x37 s5s6 D 69 N.s5s6.06