ArrestinDb

S-arrestin - DP₁ receptor complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
DP₁	77.2
S-arrestin	78.8

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.4

PAE mean: 20.7

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Aromatic	ICL2	F	138	34x51	S16	Y	259	C.S16.03
Hydrophobic	ICL2	F	138	34x51	S9	C	147	N.S9.01
Hydrophobic	ICL3	R	251	-	s9s10	D	162	N.s9s10.04
Hydrophobic	TM3	C	130	3x50	s5s6	V	78	N.s5s6.07
Hydrophobic	TM5	M	228	5x66	s15s16	Y	254	C.s15s16.03
Hydrophobic	ICL2	P	137	34x50	S16	D	257	C.S16.01
Hydrophobic	TM3	L	134	3x54	S6	F	83	N.S6.01
Hydrophobic	H8	R	332	8x52	s5s6	G	80	N.s5s6.09
Hydrophobic	TM6	H	263	6x33	s5s6	L	81	N.s5s6.10
Hydrophobic	TM6	Q	256	6x26	s9s10	D	166	N.s9s10.08
Hydrophobic	TM5	S	238	5x76	s7s8	Y	129	N.s7s8.05
Hydrophobic	TM5	R	231	5x69	s17s18	T	323	C.s17s18.39
Hydrophobic	TM3	S	133	3x53	s5s6	V	78	N.s5s6.07
Hydrophobic	TM6	E	259	6x29	s5s6	L	81	N.s5s6.10
Hydrophobic	ICL2	F	138	34x51	S5	Y	71	N.S5.12
Hydrophobic	ICL2	P	137	34x50	s15s16	S	255	C.s15s16.04
Hydrophobic	ICL1	L	54	-	s20c	R	398	C.s20c.17
Hydrophobic	ICL2	F	138	34x51	S8	L	136	N.S8.03
Hydrophobic	TM5	H	235	5x73	s17s18	V	324	C.s17s18.40
Hydrophobic	ICL2	R	141	34x54	s8s9	P	138	N.s8s9.02
Hydrophobic	TM2	F	61	2x39	s5s6	V	78	N.s5s6.07
Hydrophobic	TM5	H	235	5x73	s17s18	D	321	C.s17s18.37
Hydrophobic	H8	R	327	8x47	s5s6	I	79	N.s5s6.08
Hydrophobic	TM2	S	59	2x37	s5s6	D	77	N.s5s6.06
Hydrophobic	TM5	M	228	5x66	S6	F	83	N.S6.01
Hydrophobic	TM2	F	61	2x39	s5s6	D	77	N.s5s6.06
Hydrophobic	ICL2	R	141	34x54	s8s9	K	145	N.s8s9.09
Hydrophobic	TM3	H	136	3x56	S16	D	257	C.S16.01
Hydrophobic	ICL2	Y	140	34x53	s8s9	K	145	N.s8s9.09
Hydrophobic	ICL2	R	141	34x54	s8s9	S	146	N.s8s9.10
Hydrophobic	ICL2	P	137	34x50	S5	Y	71	N.S5.12
Hydrophobic	ICL2	Y	140	34x53	s5s6	V	78	N.s5s6.07
Hydrophobic	TM3	C	130	3x50	s5s6	I	79	N.s5s6.08
Hydrophobic	TM5	R	231	5x69	S6	R	85	N.S6.03
Hydrophobic	ICL2	F	138	34x51	S16	D	257	C.S16.01
Hydrophobic	TM3	G	135	3x55	s15s16	S	255	C.s15s16.04
Hydrophobic	TM3	E	129	3x49	s5s6	V	78	N.s5s6.07
Hydrophobic	ICL1	L	54	-	s20c	E	394	C.s20c.13
Hydrophobic	ICL1	P	53	-	s20c	R	398	C.s20c.17
Hydrophobic	ICL2	F	138	34x51	S16	Y	259	C.S16.03
Hydrophobic	TM5	L	232	5x70	S6	R	85	N.S6.03
Hydrophobic	ICL2	F	138	34x51	S15	V	251	C.S15.14
Hydrophobic	TM6	H	263	6x33	s5s6	I	79	N.s5s6.08
Ionic	ICL3	R	251	-	s9s10	D	162	N.s9s10.04
Ionic	TM5	H	235	5x73	s17s18	D	321	C.s17s18.37
Ionic	TM3	H	136	3x56	S16	D	257	C.S16.01
Ionic	ICL1	R	51	-	s20c	E	405	C.s20c.24
Polar	ICL3	R	251	-	s9s10	D	162	N.s9s10.04
Polar	ICL2	P	137	34x50	S16	D	257	C.S16.01
Polar	TM5	R	231	5x69	s15s16	V	252	C.s15s16.01
Polar	H8	R	332	8x52	s5s6	G	80	N.s5s6.09
Polar	TM6	Q	256	6x26	s9s10	D	166	N.s9s10.08
Polar	TM5	S	238	5x76	s7s8	Y	129	N.s7s8.05
Polar	H8	R	327	8x47	s5s6	V	78	N.s5s6.07
Polar	ICL2	F	138	34x51	S5	Y	71	N.S5.12
Polar	TM5	H	235	5x73	s17s18	D	321	C.s17s18.37
Polar	TM2	S	59	2x37	s5s6	D	77	N.s5s6.06
Polar	H8	R	332	8x52	s5s6	I	79	N.s5s6.08
Polar	ICL2	R	141	34x54	S8	L	136	N.S8.03
Polar	ICL2	R	141	34x54	s8s9	K	145	N.s8s9.09
Polar	TM5	R	231	5x69	s15s16	L	253	C.s15s16.02
Polar	TM3	H	136	3x56	S16	D	257	C.S16.01
Polar	ICL2	P	137	34x50	S5	Y	71	N.S5.12
Polar	TM5	R	231	5x69	S6	R	85	N.S6.03
Polar	ICL2	F	138	34x51	S16	D	257	C.S16.01
Polar	ICL2	F	138	34x51	S16	Y	259	C.S16.03
Polar	TM5	L	232	5x70	S6	R	85	N.S6.03
Polar	TM6	H	263	6x33	s5s6	I	79	N.s5s6.08
Van-der-waals	ICL3	R	251	-	s9s10	D	162	N.s9s10.04
Van-der-waals	TM5	M	228	5x66	s15s16	Y	254	C.s15s16.03
Van-der-waals	ICL2	P	137	34x50	S16	D	257	C.S16.01
Van-der-waals	TM3	L	134	3x54	S6	F	83	N.S6.01
Van-der-waals	TM5	R	231	5x69	s15s16	V	252	C.s15s16.01
Van-der-waals	H8	R	332	8x52	s5s6	G	80	N.s5s6.09
Van-der-waals	TM6	H	263	6x33	s5s6	L	81	N.s5s6.10
Van-der-waals	TM6	Q	256	6x26	s9s10	D	166	N.s9s10.08
Van-der-waals	TM5	S	238	5x76	s7s8	Y	129	N.s7s8.05
Van-der-waals	H8	R	327	8x47	s5s6	V	78	N.s5s6.07
Van-der-waals	ICL2	P	137	34x50	s15s16	S	255	C.s15s16.04
Van-der-waals	ICL1	L	54	-	s20c	R	398	C.s20c.17
Van-der-waals	ICL2	F	138	34x51	S8	L	136	N.S8.03
Van-der-waals	TM5	H	235	5x73	s17s18	V	324	C.s17s18.40
Van-der-waals	ICL2	R	141	34x54	s8s9	P	138	N.s8s9.02
Van-der-waals	TM2	F	61	2x39	s5s6	V	78	N.s5s6.07
Van-der-waals	H8	R	327	8x47	s5s6	I	79	N.s5s6.08
Van-der-waals	TM2	S	59	2x37	s5s6	D	77	N.s5s6.06
Van-der-waals	H8	R	332	8x52	s5s6	I	79	N.s5s6.08
Van-der-waals	TM5	M	228	5x66	S6	F	83	N.S6.01
Van-der-waals	TM2	F	61	2x39	s5s6	D	77	N.s5s6.06
Van-der-waals	ICL2	R	141	34x54	s8s9	K	145	N.s8s9.09
Van-der-waals	TM5	R	231	5x69	s15s16	L	253	C.s15s16.02
Van-der-waals	TM3	H	136	3x56	S16	D	257	C.S16.01
Van-der-waals	ICL2	Y	140	34x53	s8s9	K	145	N.s8s9.09
Van-der-waals	ICL2	R	141	34x54	s8s9	S	146	N.s8s9.10
Van-der-waals	ICL2	P	137	34x50	S5	Y	71	N.S5.12
Van-der-waals	ICL3	D	249	-	s9s10	D	162	N.s9s10.04
Van-der-waals	TM5	R	231	5x69	S6	R	85	N.S6.03
Van-der-waals	ICL2	F	138	34x51	S16	D	257	C.S16.01
Van-der-waals	TM3	G	135	3x55	s15s16	S	255	C.s15s16.04
Van-der-waals	TM3	E	129	3x49	s5s6	V	78	N.s5s6.07
Van-der-waals	ICL1	L	54	-	s20c	E	394	C.s20c.13
Van-der-waals	ICL1	P	53	-	s20c	R	398	C.s20c.17
Van-der-waals	ICL2	F	138	34x51	S16	Y	259	C.S16.03
Van-der-waals	TM5	L	232	5x70	S6	R	85	N.S6.03
Van-der-waals	ICL2	F	138	34x51	S15	V	251	C.S15.14
Van-der-waals	TM6	H	263	6x33	s5s6	I	79	N.s5s6.08

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Main reference

S-arrestin - DP1 receptor complex model Download Full