ArrestinDb

Beta-arrestin-2 - EP₁ receptor complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
EP₁	70.9
Beta-arrestin-2	77.8

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.5

iPTM Score: 0.3

PAE mean: 24.1

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	TM3	V	139	3x54	s5s6	L	74	N.s5s6.10
Hydrophobic	TM2	F	73	2x39	s5s6	V	71	N.s5s6.07
Hydrophobic	ICL2	L	143	34x51	S15	I	242	C.S15.14
Hydrophobic	TM2	S	69	2x35	s5s6	R	66	N.s5s6.02
Hydrophobic	ICL2	L	143	34x51	S16	Y	250	C.S16.03
Hydrophobic	ICL2	V	149	34x57	s8s9	T	137	N.s8s9.07
Hydrophobic	ICL2	A	147	34x55	s8s9	D	136	N.s8s9.06
Hydrophobic	TM2	S	69	2x35	s5s6	D	68	N.s5s6.04
Hydrophobic	TM2	F	73	2x39	s5s6	L	72	N.s5s6.08
Hydrophobic	TM6	M	295	6x33	s5s6	L	74	N.s5s6.10
Hydrophobic	TM2	L	74	2x40	s5s6	V	71	N.s5s6.07
Hydrophobic	TM3	R	135	3x50	s5s6	L	72	N.s5s6.08
Hydrophobic	ICL2	P	142	34x50	s15s16	S	246	C.s15s16.04
Hydrophobic	TM2	R	68	2x34	s5s6	R	66	N.s5s6.02
Hydrophobic	TM5	L	229	5x63	s5s6	L	74	N.s5s6.10
Hydrophobic	ICL2	A	147	34x55	s8s9	E	135	N.s8s9.05
Hydrophobic	TM6	R	287	6x25	s9s10	K	158	N.s9s10.09
Hydrophobic	ICL1	L	64	12x50	s5s6	V	71	N.s5s6.07
Hydrophobic	ICL2	L	143	34x51	S16	Q	249	C.S16.02
Hydrophobic	TM2	A	71	2x37	s5s6	D	68	N.s5s6.04
Hydrophobic	TM2	R	66	2x32	s20c	D	402	C.s20c.12
Hydrophobic	ICL2	L	143	34x51	s15s16	S	246	C.s15s16.04
Hydrophobic	TM2	R	67	2x33	s5s6	D	68	N.s5s6.04
Hydrophobic	TM2	S	69	2x35	s8s9	K	139	N.s8s9.09
Hydrophobic	ICL2	H	145	34x53	s5s6	R	66	N.s5s6.02
Hydrophobic	ICL2	H	145	34x53	s8s9	T	137	N.s8s9.07
Hydrophobic	ICL2	L	143	34x51	S16	A	248	C.S16.01
Hydrophobic	ICL3	S	284	-	S6	D	79	N.S6.04
Hydrophobic	TM3	R	141	3x56	s15s16	S	246	C.s15s16.04
Hydrophobic	ICL2	A	146	34x54	s8s9	D	136	N.s8s9.06
Hydrophobic	ICL2	V	149	34x57	s5s6	R	66	N.s5s6.02
Hydrophobic	ICL2	A	146	34x54	s8s9	T	137	N.s8s9.07
Hydrophobic	TM5	R	236	5x70	S6	K	78	N.S6.03
Hydrophobic	ICL3	S	284	-	S6	I	82	N.S6.07
Hydrophobic	TM5	R	239	5x73	s17s18	N	312	C.s17s18.37
Hydrophobic	ICL2	R	148	34x56	s8s9	T	137	N.s8s9.07
Hydrophobic	TM2	R	68	2x34	s5s6	D	68	N.s5s6.04
Hydrophobic	H8	R	355	8x47	s5s6	L	72	N.s5s6.08
Hydrophobic	TM3	V	139	3x54	S6	F	76	N.S6.01
Hydrophobic	TM2	A	70	2x36	s5s6	D	68	N.s5s6.04
Hydrophobic	ICL1	L	64	12x50	s5s6	E	67	N.s5s6.03
Hydrophobic	TM2	R	67	2x33	s5s6	D	70	N.s5s6.06
Hydrophobic	ICL2	P	142	34x50	s15s16	F	245	C.s15s16.03
Hydrophobic	TM2	A	70	2x36	s5s6	V	71	N.s5s6.07
Hydrophobic	ICL2	L	143	34x51	s15s16	T	247	C.s15s16.05
Hydrophobic	H8	R	355	8x47	s5s6	V	71	N.s5s6.07
Hydrophobic	ICL2	A	146	34x54	s8s9	G	138	N.s8s9.08
Hydrophobic	ICL2	P	142	34x50	S5	Y	64	N.S5.12
Hydrophobic	TM4	S	150	4x38	s8s9	T	137	N.s8s9.07
Hydrophobic	TM5	L	229	5x63	S6	F	76	N.S6.01
Hydrophobic	TM6	H	291	6x29	s5s6	G	73	N.s5s6.09
Hydrophobic	ICL3	S	281	-	S6	I	82	N.S6.07
Hydrophobic	TM2	A	70	2x36	s5s6	E	67	N.s5s6.03
Hydrophobic	TM5	R	236	5x70	s15s16	F	245	C.s15s16.03
Hydrophobic	ICL3	R	280	-	s9s10	L	155	N.s9s10.03
Hydrophobic	TM2	R	67	2x33	s5s6	E	67	N.s5s6.03
Ionic	TM2	R	66	2x32	s20c	D	403	C.s20c.13
Ionic	TM2	R	67	2x33	s5s6	D	70	N.s5s6.06
Ionic	TM5	R	239	5x73	s17s18	E	314	C.s17s18.39
Ionic	TM5	R	235	5x69	s17s18	E	314	C.s17s18.39
Ionic	TM2	R	67	2x33	s5s6	E	67	N.s5s6.03
Polar	ICL2	L	143	34x51	S5	Y	64	N.S5.12
Polar	TM2	S	69	2x35	s5s6	R	66	N.s5s6.02
Polar	TM5	R	236	5x70	S6	R	77	N.S6.02
Polar	ICL2	L	143	34x51	S16	Y	250	C.S16.03
Polar	TM2	R	66	2x32	s20c	D	403	C.s20c.13
Polar	ICL2	A	147	34x55	s8s9	T	137	N.s8s9.07
Polar	ICL2	V	149	34x57	s8s9	T	137	N.s8s9.07
Polar	TM2	S	69	2x35	s5s6	D	68	N.s5s6.04
Polar	TM2	T	72	2x38	s5s6	D	68	N.s5s6.04
Polar	ICL2	P	142	34x50	s15s16	S	246	C.s15s16.04
Polar	TM2	A	71	2x37	s5s6	D	68	N.s5s6.04
Polar	TM2	R	66	2x32	s20c	D	402	C.s20c.12
Polar	ICL2	A	146	34x54	s5s6	R	66	N.s5s6.02
Polar	ICL2	L	143	34x51	s15s16	S	246	C.s15s16.04
Polar	ICL2	H	145	34x53	s5s6	R	66	N.s5s6.02
Polar	ICL2	H	145	34x53	s8s9	T	137	N.s8s9.07
Polar	TM2	S	69	2x35	s5s6	L	69	N.s5s6.05
Polar	ICL3	S	284	-	S6	D	79	N.S6.04
Polar	ICL2	A	146	34x54	s8s9	D	136	N.s8s9.06
Polar	ICL2	V	149	34x57	s5s6	R	66	N.s5s6.02
Polar	ICL2	A	146	34x54	s8s9	T	137	N.s8s9.07
Polar	TM5	R	239	5x73	s17s18	N	312	C.s17s18.37
Polar	ICL2	R	148	34x56	s8s9	T	137	N.s8s9.07
Polar	TM2	R	68	2x34	s5s6	D	68	N.s5s6.04
Polar	TM2	A	70	2x36	s5s6	D	68	N.s5s6.04
Polar	TM2	R	67	2x33	s5s6	D	70	N.s5s6.06
Polar	TM2	T	72	2x38	s5s6	R	66	N.s5s6.02
Polar	TM5	R	239	5x73	s17s18	E	314	C.s17s18.39
Polar	H8	R	355	8x47	s5s6	V	71	N.s5s6.07
Polar	ICL2	A	146	34x54	s8s9	G	138	N.s8s9.08
Polar	TM2	S	69	2x35	s5s6	E	67	N.s5s6.03
Polar	ICL2	P	142	34x50	S5	Y	64	N.S5.12
Polar	TM6	H	291	6x29	s5s6	G	73	N.s5s6.09
Polar	TM5	R	235	5x69	s17s18	E	314	C.s17s18.39
Polar	TM2	R	67	2x33	s5s6	E	67	N.s5s6.03
Van-der-waals	ICL2	A	146	34x54	s8s9	E	135	N.s8s9.05
Van-der-waals	ICL2	L	143	34x51	S5	Y	64	N.S5.12
Van-der-waals	ICL2	L	143	34x51	S15	I	242	C.S15.14
Van-der-waals	TM2	S	69	2x35	s5s6	R	66	N.s5s6.02
Van-der-waals	ICL2	L	143	34x51	S16	Y	250	C.S16.03
Van-der-waals	ICL2	A	147	34x55	s8s9	T	137	N.s8s9.07
Van-der-waals	ICL2	V	149	34x57	s8s9	T	137	N.s8s9.07
Van-der-waals	ICL2	A	147	34x55	s8s9	D	136	N.s8s9.06
Van-der-waals	TM2	S	69	2x35	s5s6	D	68	N.s5s6.04
Van-der-waals	TM2	F	73	2x39	s5s6	L	72	N.s5s6.08
Van-der-waals	TM6	M	295	6x33	s5s6	L	74	N.s5s6.10
Van-der-waals	TM3	R	135	3x50	s5s6	L	72	N.s5s6.08
Van-der-waals	ICL2	P	142	34x50	s15s16	S	246	C.s15s16.04
Van-der-waals	TM5	L	229	5x63	s5s6	L	74	N.s5s6.10
Van-der-waals	ICL2	A	147	34x55	s8s9	E	135	N.s8s9.05
Van-der-waals	TM2	R	66	2x32	s5s6	E	67	N.s5s6.03
Van-der-waals	TM6	R	287	6x25	s9s10	K	158	N.s9s10.09
Van-der-waals	ICL1	L	64	12x50	s5s6	V	71	N.s5s6.07
Van-der-waals	ICL2	L	143	34x51	S16	Q	249	C.S16.02
Van-der-waals	TM2	A	71	2x37	s5s6	D	68	N.s5s6.04
Van-der-waals	TM2	R	66	2x32	s20c	D	402	C.s20c.12
Van-der-waals	ICL2	L	143	34x51	s15s16	S	246	C.s15s16.04
Van-der-waals	TM2	R	67	2x33	s5s6	D	68	N.s5s6.04
Van-der-waals	ICL2	H	145	34x53	s5s6	R	66	N.s5s6.02
Van-der-waals	ICL2	H	145	34x53	s8s9	T	137	N.s8s9.07
Van-der-waals	ICL2	L	143	34x51	S16	A	248	C.S16.01
Van-der-waals	ICL3	S	284	-	S6	D	79	N.S6.04
Van-der-waals	ICL2	A	146	34x54	s8s9	D	136	N.s8s9.06
Van-der-waals	ICL2	V	149	34x57	s5s6	R	66	N.s5s6.02
Van-der-waals	ICL2	A	146	34x54	s8s9	T	137	N.s8s9.07
Van-der-waals	TM5	R	236	5x70	S6	K	78	N.S6.03
Van-der-waals	ICL3	S	284	-	S6	I	82	N.S6.07
Van-der-waals	TM5	R	239	5x73	s17s18	N	312	C.s17s18.37
Van-der-waals	TM2	R	68	2x34	s5s6	D	68	N.s5s6.04
Van-der-waals	H8	R	355	8x47	s5s6	L	72	N.s5s6.08
Van-der-waals	TM3	V	139	3x54	S6	F	76	N.S6.01
Van-der-waals	TM2	A	70	2x36	s5s6	D	68	N.s5s6.04
Van-der-waals	TM2	R	67	2x33	s5s6	D	70	N.s5s6.06
Van-der-waals	ICL2	P	142	34x50	s15s16	F	245	C.s15s16.03
Van-der-waals	TM2	A	70	2x36	s5s6	V	71	N.s5s6.07
Van-der-waals	ICL2	L	143	34x51	s15s16	T	247	C.s15s16.05
Van-der-waals	H8	R	355	8x47	s5s6	V	71	N.s5s6.07
Van-der-waals	ICL2	A	146	34x54	s8s9	G	138	N.s8s9.08
Van-der-waals	TM2	S	69	2x35	s5s6	E	67	N.s5s6.03
Van-der-waals	ICL2	P	142	34x50	S5	Y	64	N.S5.12
Van-der-waals	TM4	S	150	4x38	s8s9	T	137	N.s8s9.07
Van-der-waals	TM5	L	229	5x63	S6	F	76	N.S6.01
Van-der-waals	TM6	H	291	6x29	s5s6	G	73	N.s5s6.09
Van-der-waals	TM5	R	236	5x70	s15s16	F	245	C.s15s16.03
Van-der-waals	ICL3	R	280	-	s9s10	L	155	N.s9s10.03
Van-der-waals	TM2	R	67	2x33	s5s6	E	67	N.s5s6.03
Van-der-waals	ICL2	A	146	34x54	S16	Y	250	C.S16.03
Van-der-waals	H8	R	360	8x52	s9s10	K	158	N.s9s10.09

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Main reference

Beta-arrestin-2 - EP1 receptor complex model Download Full