S-arrestin - EP1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
EP1 71.3
S-arrestin 78.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM2 R 68 2x34 s8s9 P 140 N.s8s9.04
Van-der-waals TM2 R 68 2x34 s8s9 P 140 N.s8s9.04
Hydrophobic TM2 R 67 2x33 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 R 67 2x33 s5s6 Q 73 N.s5s6.02
Polar TM2 R 66 2x32 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL1 L 64 12x50 s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 L 64 12x50 s5s6 D 75 N.s5s6.04
Van-der-waals TM3 T 140 3x55 s15s16 Y 254 C.s15s16.03
Polar ICL2 L 143 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 143 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 143 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 143 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 L 143 34x51 S9 C 147 N.S9.01
Hydrophobic TM6 Q 298 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 Q 298 6x36 s5s6 I 79 N.s5s6.08
Polar ICL2 A 146 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 A 146 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 A 146 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals H8 R 355 8x47 s5s6 G 80 N.s5s6.09
Polar ICL3 R 280 - S5 Y 62 N.S5.03
Van-der-waals ICL3 R 280 - S5 Y 62 N.S5.03
Ionic TM5 R 239 5x73 s17s18 D 321 C.s17s18.37
Polar TM5 R 239 5x73 s17s18 D 321 C.s17s18.37
Hydrophobic TM5 R 239 5x73 s17s18 D 321 C.s17s18.37
Van-der-waals TM5 R 239 5x73 s17s18 D 321 C.s17s18.37
Ionic TM2 R 66 2x32 s20c E 395 C.s20c.14
Polar TM2 R 66 2x32 s20c E 395 C.s20c.14
Hydrophobic TM2 R 66 2x32 s20c E 395 C.s20c.14
Van-der-waals TM2 R 66 2x32 s20c E 395 C.s20c.14
Polar H8 R 355 8x47 s5s6 D 77 N.s5s6.06
Polar TM2 R 68 2x34 s5s6 Q 73 N.s5s6.02
Hydrophobic TM2 R 68 2x34 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 R 68 2x34 s5s6 Q 73 N.s5s6.02
Hydrophobic TM2 A 70 2x36 s5s6 V 78 N.s5s6.07
Hydrophobic ICL3 G 283 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 G 283 - s9s10 A 163 N.s9s10.05
Polar ICL2 L 143 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 L 143 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 143 34x51 S16 Y 259 C.S16.03
Polar TM2 R 68 2x34 s8s9 Q 141 N.s8s9.05
Hydrophobic TM2 R 68 2x34 s8s9 Q 141 N.s8s9.05
Van-der-waals TM2 R 68 2x34 s8s9 Q 141 N.s8s9.05
Hydrophobic TM5 R 236 5x70 S6 R 85 N.S6.03
Van-der-waals TM5 R 236 5x70 S6 R 85 N.S6.03
Hydrophobic ICL2 L 143 34x51 S8 L 136 N.S8.03
Polar ICL3 S 284 - S6 D 86 N.S6.04
Van-der-waals ICL3 S 284 - S6 D 86 N.S6.04
Hydrophobic TM5 L 229 5x63 s5s6 L 81 N.s5s6.10
Hydrophobic H8 R 355 8x47 s5s6 I 79 N.s5s6.08
Van-der-waals H8 R 355 8x47 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 P 142 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 142 34x50 s15s16 Y 254 C.s15s16.03
Polar ICL3 S 284 - s9s10 A 163 N.s9s10.05
Hydrophobic TM6 M 295 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 V 139 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 139 3x54 S6 F 83 N.S6.01
Hydrophobic TM2 A 70 2x36 s5s6 D 75 N.s5s6.04
Polar TM5 R 236 5x70 S6 R 84 N.S6.02
Polar TM2 R 68 2x34 s8s9 S 143 N.s8s9.07
Van-der-waals TM2 R 68 2x34 s8s9 S 143 N.s8s9.07
Hydrophobic TM3 G 138 3x53 S6 F 83 N.S6.01
Hydrophobic TM2 S 69 2x35 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 S 69 2x35 s5s6 I 76 N.s5s6.05
Hydrophobic TM2 A 70 2x36 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 H 291 6x29 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 H 291 6x29 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 S 69 2x35 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 S 69 2x35 s5s6 V 78 N.s5s6.07
Polar ICL3 S 281 - S6 F 89 N.S6.07
Hydrophobic ICL3 S 281 - S6 F 89 N.S6.07
Van-der-waals ICL3 S 281 - S6 F 89 N.S6.07
Hydrophobic ICL3 R 280 - s9s10 T 161 N.s9s10.03
Van-der-waals ICL3 R 280 - s9s10 T 161 N.s9s10.03
Ionic TM2 R 67 2x33 s5s6 D 75 N.s5s6.04
Polar TM2 R 67 2x33 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 R 67 2x33 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 R 67 2x33 s5s6 D 75 N.s5s6.04
Polar TM6 H 291 6x29 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 H 291 6x29 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 H 291 6x29 s5s6 G 80 N.s5s6.09
Hydrophobic ICL3 S 284 - S6 F 89 N.S6.07
Van-der-waals ICL3 S 284 - S6 F 89 N.S6.07
Polar TM5 R 236 5x70 S6 D 86 N.S6.04
Polar H8 R 355 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 R 355 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 R 355 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 R 287 6x25 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 287 6x25 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 M 295 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 M 295 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 A 146 34x54 S5 Y 71 N.S5.12
Van-der-waals ICL2 A 146 34x54 S5 Y 71 N.S5.12
Ionic H8 R 360 8x52 s9s10 D 166 N.s9s10.08
Hydrophobic TM2 F 73 2x39 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 F 73 2x39 s5s6 I 79 N.s5s6.08
Polar ICL2 L 144 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 L 144 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 L 144 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 P 142 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 P 142 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 R 135 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 135 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 R 239 5x73 s17s18 V 324 C.s17s18.40
Van-der-waals TM5 R 239 5x73 s17s18 V 324 C.s17s18.40
Ionic TM6 R 287 6x25 s9s10 D 166 N.s9s10.08
Polar TM6 R 287 6x25 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 R 287 6x25 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 R 287 6x25 s9s10 D 166 N.s9s10.08
Hydrophobic ICL3 S 284 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 S 284 - s9s10 E 165 N.s9s10.07
Polar TM2 S 69 2x35 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 S 69 2x35 s5s6 Q 73 N.s5s6.02
Hydrophobic TM2 R 68 2x34 s8s9 G 144 N.s8s9.08
Polar ICL2 A 147 34x55 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 A 147 34x55 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 A 147 34x55 s8s9 K 145 N.s8s9.09
Hydrophobic ICL1 L 64 12x50 s5s6 D 77 N.s5s6.06
Van-der-waals ICL1 L 64 12x50 s5s6 D 77 N.s5s6.06
Ionic TM2 R 67 2x33 s5s6 E 74 N.s5s6.03
Polar TM2 R 67 2x33 s5s6 E 74 N.s5s6.03
Hydrophobic TM2 R 67 2x33 s5s6 E 74 N.s5s6.03
Van-der-waals TM2 R 67 2x33 s5s6 E 74 N.s5s6.03
Polar ICL2 L 143 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 L 143 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 L 143 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic TM6 H 291 6x29 s5s6 L 81 N.s5s6.10
Polar ICL2 P 142 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 142 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 142 34x50 S5 Y 71 N.S5.12
Ionic TM6 R 287 6x25 s9s10 E 164 N.s9s10.06
Polar TM6 R 287 6x25 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 R 287 6x25 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 287 6x25 s9s10 E 164 N.s9s10.06
Hydrophobic ICL3 R 280 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 R 280 - s9s10 A 163 N.s9s10.05
Polar ICL2 L 143 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 L 143 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 L 143 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 L 143 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 143 34x51 S15 V 251 C.S15.14
Hydrophobic TM3 R 141 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic TM2 F 73 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 F 73 2x39 s5s6 V 78 N.s5s6.07