Beta-arrestin-2 - EP2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
EP2 76.6
Beta-arrestin-2 77.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 Y 142 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 Y 142 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 Y 142 34x51 S5 Y 64 N.S5.12
Polar ICL2 Q 145 34x54 s8s9 G 138 N.s8s9.08
Polar ICL2 Y 142 34x51 S9 C 141 N.S9.01
Hydrophobic ICL2 Y 142 34x51 S9 C 141 N.S9.01
Van-der-waals ICL2 Y 142 34x51 S9 C 141 N.S9.01
Hydrophobic ICL1 A 58 - s20c Y 404 C.s20c.14
Van-der-waals ICL1 A 58 - s20c Y 404 C.s20c.14
Hydrophobic TM5 L 222 5x63 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 M 269 6x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 M 269 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 134 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 134 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 I 138 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 138 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 L 265 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 Y 142 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 Y 142 34x51 S15 I 242 C.S15.14
Hydrophobic TM3 I 138 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 138 3x54 S6 F 76 N.S6.01
Polar ICL2 Q 145 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 Q 145 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 Q 145 34x54 s8s9 D 136 N.s8s9.06
Ionic TM1 R 49 1x60 s5s6 D 70 N.s5s6.06
Polar TM1 R 49 1x60 s5s6 D 70 N.s5s6.06
Hydrophobic TM1 R 49 1x60 s5s6 D 70 N.s5s6.06
Van-der-waals TM1 R 49 1x60 s5s6 D 70 N.s5s6.06
Polar TM2 S 65 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 65 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 65 2x37 s5s6 D 68 N.s5s6.04
Polar TM5 R 228 5x69 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 228 5x69 s15s16 F 245 C.s15s16.03
Aromatic ICL2 Y 142 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 Y 142 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 Y 142 34x51 S16 Y 250 C.S16.03
Polar ICL2 R 146 34x55 s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 R 146 34x55 s17s18 R 286 C.s17s18.11
Hydrophobic H8 P 320 8x48 s5s6 L 72 N.s5s6.08
Van-der-waals H8 P 320 8x48 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 Y 144 34x53 s5s6 L 69 N.s5s6.05
Van-der-waals ICL2 Y 144 34x53 s5s6 L 69 N.s5s6.05
Polar ICL1 G 59 - s20c Y 404 C.s20c.14
Hydrophobic ICL1 G 59 - s20c Y 404 C.s20c.14
Van-der-waals ICL1 G 59 - s20c Y 404 C.s20c.14
Ionic ICL1 R 61 - s20c D 402 C.s20c.12
Polar ICL1 R 61 - s20c D 402 C.s20c.12
Van-der-waals ICL1 R 61 - s20c D 402 C.s20c.12
Ionic ICL3 R 250 - s9s10 E 156 N.s9s10.07
Polar ICL3 R 250 - s9s10 E 156 N.s9s10.07
Hydrophobic ICL3 R 250 - s9s10 E 156 N.s9s10.07
Van-der-waals ICL3 R 250 - s9s10 E 156 N.s9s10.07
Hydrophobic TM3 E 133 3x49 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 E 133 3x49 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 F 67 2x39 s5s6 D 70 N.s5s6.06
Hydrophobic TM2 F 67 2x39 s5s6 D 70 N.s5s6.06
Polar TM5 R 228 5x69 S6 K 78 N.S6.03
Hydrophobic ICL1 R 60 - s9s10 K 161 N.s9s10.12
Van-der-waals ICL1 R 60 - s9s10 K 161 N.s9s10.12
Polar TM6 H 262 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 H 262 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 H 262 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 H 68 2x40 s5s6 D 70 N.s5s6.06
Polar ICL2 P 141 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 141 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 141 34x50 S5 Y 64 N.S5.12
Hydrophobic TM5 M 225 5x66 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 M 225 5x66 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 M 225 5x66 S6 F 76 N.S6.01
Van-der-waals TM5 M 225 5x66 S6 F 76 N.S6.01
Hydrophobic TM5 S 229 5x70 S6 K 78 N.S6.03
Hydrophobic ICL2 Y 142 34x51 S16 A 248 C.S16.01
Polar TM5 S 232 5x73 S6 K 78 N.S6.03
Van-der-waals TM5 S 232 5x73 S6 K 78 N.S6.03
Hydrophobic TM3 R 134 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 134 3x50 s5s6 L 72 N.s5s6.08
Polar ICL1 S 63 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL1 S 63 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL1 S 63 - s5s6 D 68 N.s5s6.04
Polar TM6 H 262 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 H 262 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 H 262 6x33 s5s6 L 72 N.s5s6.08
Polar ICL1 S 63 - s8s9 T 137 N.s8s9.07
Hydrophobic TM5 S 232 5x73 s17s18 V 315 C.s17s18.40
Van-der-waals TM5 S 232 5x73 s17s18 V 315 C.s17s18.40
Hydrophobic TM3 S 137 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 S 137 3x53 s5s6 L 69 N.s5s6.05
Polar ICL2 Q 145 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 Q 145 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Q 145 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 S 137 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 Y 142 34x51 S8 L 130 N.S8.03
Van-der-waals ICL2 Y 142 34x51 S8 L 130 N.S8.03
Hydrophobic TM5 R 228 5x69 s15s16 T 247 C.s15s16.05
Polar TM6 H 262 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 H 262 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 H 262 6x33 s5s6 G 73 N.s5s6.09
Ionic TM5 R 228 5x69 s17s18 E 314 C.s17s18.39
Polar TM5 R 228 5x69 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 R 228 5x69 s17s18 E 314 C.s17s18.39
Hydrophobic TM2 S 65 2x37 s5s6 D 70 N.s5s6.06
Polar TM6 S 255 6x26 S6 R 77 N.S6.02
Polar ICL2 V 148 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 V 148 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 V 148 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 L 266 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 Q 145 34x54 s8s9 A 140 N.s8s9.10
Van-der-waals ICL2 Q 145 34x54 s8s9 A 140 N.s8s9.10
Hydrophobic ICL2 Y 144 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 P 141 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 L 222 5x63 S6 F 76 N.S6.01
Van-der-waals TM5 L 222 5x63 S6 F 76 N.S6.01
Hydrophobic TM2 F 67 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 F 67 2x39 s5s6 V 71 N.s5s6.07