Arrestin-C - EP3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
EP3 72.3
Arrestin-C 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM3 A 158 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic TM3 A 158 3x53 s8s9 K 135 N.s8s9.09
Van-der-waals TM3 A 158 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic TM3 R 155 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 155 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 I 159 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 159 3x54 S6 F 71 N.S6.01
Hydrophobic TM3 I 159 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 159 3x54 s5s6 L 69 N.s5s6.10
Polar ICL1 K 83 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL1 K 83 - s5s6 R 61 N.s5s6.02
Ionic H8 R 361 8x58 s9s10 E 152 N.s9s10.07
Polar H8 R 361 8x58 s9s10 E 152 N.s9s10.07
Hydrophobic H8 R 361 8x58 s9s10 E 152 N.s9s10.07
Van-der-waals H8 R 361 8x58 s9s10 E 152 N.s9s10.07
Polar ICL1 R 84 - s8s9 D 132 N.s8s9.06
Van-der-waals ICL1 R 84 - s8s9 D 132 N.s8s9.06
Hydrophobic ICL1 R 80 - s5s6 V 66 N.s5s6.07
Van-der-waals ICL1 R 80 - s5s6 V 66 N.s5s6.07
Polar H8 Y 362 8x59 s9s10 E 153 N.s9s10.08
Hydrophobic H8 Y 362 8x59 s9s10 E 153 N.s9s10.08
Van-der-waals H8 Y 362 8x59 s9s10 E 153 N.s9s10.08
Polar H8 R 350 8x47 s5s6 G 68 N.s5s6.09
Hydrophobic H8 R 350 8x47 s5s6 G 68 N.s5s6.09
Van-der-waals H8 R 350 8x47 s5s6 G 68 N.s5s6.09
Hydrophobic ICL2 H 163 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 H 163 34x51 S8 L 126 N.S8.03
Polar TM5 R 259 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 R 259 5x68 s15s16 Y 241 C.s15s16.03
Polar TM5 R 259 5x68 s15s16 V 239 C.s15s16.01
Hydrophobic TM5 R 259 5x68 s15s16 V 239 C.s15s16.01
Van-der-waals TM5 R 259 5x68 s15s16 V 239 C.s15s16.01
Ionic TM4 K 170 4x38 s8s9 E 131 N.s8s9.05
Polar TM4 K 170 4x38 s8s9 E 131 N.s8s9.05
Hydrophobic TM4 K 170 4x38 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 K 170 4x38 s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 Y 165 34x53 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 Y 165 34x53 s8s9 K 135 N.s8s9.09
Hydrophobic TM3 A 158 3x53 s5s6 L 64 N.s5s6.05
Polar H8 N 365 8x62 s9s10 N 150 N.s9s10.02
Hydrophobic H8 N 365 8x62 s9s10 N 150 N.s9s10.02
Van-der-waals H8 N 365 8x62 s9s10 N 150 N.s9s10.02
Hydrophobic TM5 K 263 5x72 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 K 263 5x72 s15s16 L 240 C.s15s16.02
Hydrophobic TM5 L 256 5x65 s5s6 L 69 N.s5s6.10
Polar TM5 R 259 5x68 s15s16 S 242 C.s15s16.04
Van-der-waals TM5 R 259 5x68 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 R 259 5x68 s15s16 L 243 C.s15s16.05
Polar ICL2 M 169 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 M 169 34x57 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 M 169 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic TM5 R 259 5x68 s15s16 L 240 C.s15s16.02
Hydrophobic TM2 K 85 2x36 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 K 85 2x36 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 Y 165 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 R 155 3x50 s5s6 L 69 N.s5s6.10
Polar ICL2 Y 165 34x53 s5s6 D 63 N.s5s6.04
Polar ICL2 P 162 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 162 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 162 34x50 S5 Y 59 N.S5.12
Polar TM6 W 273 6x26 s15s16 Y 241 C.s15s16.03
Aromatic TM6 W 273 6x26 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 W 273 6x26 s15s16 Y 241 C.s15s16.03
Van-der-waals TM6 W 273 6x26 s15s16 Y 241 C.s15s16.03
Polar ICL2 A 166 34x54 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 A 166 34x54 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 A 166 34x54 s8s9 K 135 N.s8s9.09
Hydrophobic H8 C 358 8x55 s9s10 T 154 N.s9s10.09
Polar ICL2 H 163 34x51 S5 Y 59 N.S5.12
Aromatic ICL2 H 163 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 H 163 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 H 163 34x51 S5 Y 59 N.S5.12
Polar TM4 T 171 4x39 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 T 280 6x33 s5s6 L 69 N.s5s6.10
Polar ICL2 A 166 34x54 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 A 166 34x54 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 A 166 34x54 s8s9 G 134 N.s8s9.08
Hydrophobic TM2 F 88 2x39 s5s6 V 66 N.s5s6.07
Ionic ICL1 R 80 - s5s6 E 65 N.s5s6.06
Polar ICL1 R 80 - s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 H 163 34x51 S9 C 137 N.S9.01
Hydrophobic TM5 K 263 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 K 263 5x72 S6 K 73 N.S6.03
Polar TM2 F 88 2x39 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 F 88 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 F 88 2x39 s5s6 D 63 N.s5s6.04
Polar TM2 S 87 2x38 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 S 87 2x38 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 S 87 2x38 s5s6 D 63 N.s5s6.04
Polar TM2 S 87 2x38 s5s6 R 61 N.s5s6.02
Hydrophobic TM2 S 87 2x38 s5s6 R 61 N.s5s6.02
Van-der-waals TM2 S 87 2x38 s5s6 R 61 N.s5s6.02
Ionic ICL1 R 79 - s20c E 383 C.s20c.17
Polar ICL1 R 79 - s20c E 383 C.s20c.17
Hydrophobic ICL1 R 79 - s20c E 383 C.s20c.17
Van-der-waals ICL1 R 79 - s20c E 383 C.s20c.17
Polar ICL1 R 84 - s5s6 R 61 N.s5s6.02
Hydrophobic ICL1 R 84 - s5s6 R 61 N.s5s6.02
Van-der-waals ICL1 R 84 - s5s6 R 61 N.s5s6.02
Polar ICL1 R 84 - s8s9 G 134 N.s8s9.08
Hydrophobic ICL1 R 84 - s8s9 G 134 N.s8s9.08
Van-der-waals ICL1 R 84 - s8s9 G 134 N.s8s9.08
Hydrophobic TM5 A 262 5x71 s17s18 E 310 C.s17s18.39
Polar ICL1 R 84 - s8s9 A 133 N.s8s9.07
Hydrophobic ICL1 R 84 - s8s9 A 133 N.s8s9.07
Van-der-waals ICL1 R 84 - s8s9 A 133 N.s8s9.07
Ionic TM2 K 85 2x36 s5s6 E 65 N.s5s6.06
Polar TM2 K 85 2x36 s5s6 E 65 N.s5s6.06
Hydrophobic TM2 K 85 2x36 s5s6 E 65 N.s5s6.06
Van-der-waals TM2 K 85 2x36 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 P 162 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 162 34x50 s15s16 S 242 C.s15s16.04
Polar ICL2 M 169 34x57 s8s9 G 134 N.s8s9.08
Hydrophobic TM4 K 170 4x38 s8s9 A 133 N.s8s9.07
Hydrophobic TM3 A 158 3x53 S6 F 71 N.S6.01
Hydrophobic ICL2 A 166 34x54 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 A 166 34x54 s8s9 D 132 N.s8s9.06
Ionic TM5 R 259 5x68 s17s18 E 310 C.s17s18.39
Polar TM5 R 259 5x68 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 R 259 5x68 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 R 259 5x68 s17s18 E 310 C.s17s18.39
Polar ICL2 P 162 34x50 S16 D 244 C.S16.01
Hydrophobic ICL2 P 162 34x50 S16 D 244 C.S16.01
Van-der-waals ICL2 P 162 34x50 S16 D 244 C.S16.01
Polar TM6 S 269 6x22 S6 K 73 N.S6.03
Hydrophobic TM6 S 269 6x22 S6 K 73 N.S6.03
Van-der-waals TM6 S 269 6x22 S6 K 73 N.S6.03
Polar TM6 S 269 6x22 S6 D 74 N.S6.04
Van-der-waals TM6 S 269 6x22 S6 D 74 N.S6.04
Van-der-waals ICL1 R 84 - s5s6 D 62 N.s5s6.03
Polar H8 Y 362 8x59 s9s10 T 154 N.s9s10.09
Hydrophobic H8 Y 362 8x59 s9s10 T 154 N.s9s10.09
Van-der-waals H8 Y 362 8x59 s9s10 T 154 N.s9s10.09
Hydrophobic TM2 F 88 2x39 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 F 88 2x39 s5s6 I 67 N.s5s6.08
Ionic TM2 K 85 2x36 s5s6 D 62 N.s5s6.03
Polar TM2 K 85 2x36 s5s6 D 62 N.s5s6.03
Hydrophobic TM2 K 85 2x36 s5s6 D 62 N.s5s6.03
Van-der-waals TM2 K 85 2x36 s5s6 D 62 N.s5s6.03
Hydrophobic ICL1 R 84 - s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 R 84 - s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 Y 165 34x53 s5s6 L 64 N.s5s6.05
Hydrophobic ICL3 A 266 - s17s18 L 311 C.s17s18.40
Aromatic TM6 W 273 6x26 S6 K 73 N.S6.03
Hydrophobic TM6 W 273 6x26 S6 K 73 N.S6.03
Van-der-waals TM6 W 273 6x26 S6 K 73 N.S6.03
Hydrophobic ICL2 S 167 34x55 s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 S 167 34x55 s8s9 E 131 N.s8s9.05
Polar ICL2 H 163 34x51 S16 Y 246 C.S16.03
Aromatic ICL2 H 163 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 H 163 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 H 163 34x51 S16 Y 246 C.S16.03
Polar ICL1 S 82 - s5s6 D 62 N.s5s6.03
Hydrophobic ICL1 S 82 - s5s6 D 62 N.s5s6.03
Van-der-waals ICL1 S 82 - s5s6 D 62 N.s5s6.03
Hydrophobic ICL2 H 163 34x51 S15 V 238 C.S15.14
Polar TM6 Q 272 6x25 S6 D 74 N.S6.04
Hydrophobic TM6 Q 272 6x25 S6 D 74 N.S6.04
Van-der-waals TM6 Q 272 6x25 S6 D 74 N.S6.04
Polar ICL2 S 167 34x55 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 S 167 34x55 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 S 167 34x55 s8s9 D 132 N.s8s9.06
Hydrophobic TM2 L 89 2x40 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 L 89 2x40 s5s6 V 66 N.s5s6.07
Hydrophobic ICL1 R 84 - s8s9 P 136 N.s8s9.10
Van-der-waals ICL1 R 84 - s8s9 P 136 N.s8s9.10
Polar ICL2 H 163 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 H 163 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 H 163 34x51 S16 D 244 C.S16.01
Aromatic TM5 K 263 5x72 s15s16 Y 241 C.s15s16.03
Polar ICL2 P 162 34x50 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 P 162 34x50 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 P 162 34x50 s8s9 K 135 N.s8s9.09