S-arrestin - EP4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
EP4 64.1
S-arrestin 81.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 A 209 5x64 s15s16 Y 254 C.s15s16.03
Polar ICL2 Y 125 34x51 s17s18 G 296 C.s17s18.12
Hydrophobic ICL2 Y 125 34x51 s17s18 G 296 C.s17s18.12
Van-der-waals ICL2 Y 125 34x51 s17s18 G 296 C.s17s18.12
Polar ICL1 Q 49 - s5s6 D 77 N.s5s6.06
Hydrophobic ICL1 Q 49 - s5s6 D 77 N.s5s6.06
Van-der-waals ICL1 Q 49 - s5s6 D 77 N.s5s6.06
Polar ICL3 R 256 - S6 S 90 N.S6.08
Hydrophobic ICL3 R 256 - S6 S 90 N.S6.08
Van-der-waals ICL3 R 256 - S6 S 90 N.S6.08
Hydrophobic ICL2 A 124 34x50 S5 Y 71 N.S5.12
Ionic ICL3 R 258 - s9s10 D 162 N.s9s10.04
Polar ICL3 R 258 - s9s10 D 162 N.s9s10.04
Van-der-waals ICL3 R 258 - s9s10 D 162 N.s9s10.04
Hydrophobic TM6 L 273 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 273 6x36 s5s6 I 79 N.s5s6.08
Polar ICL2 S 128 34x54 s17s18 R 295 C.s17s18.11
Van-der-waals ICL2 S 128 34x54 s17s18 R 295 C.s17s18.11
Hydrophobic TM7 Y 329 7x53 s5s6 I 79 N.s5s6.08
Polar H8 T 335 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 T 335 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 T 335 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 R 220 5x75 s17s18 L 325 C.s17s18.41
Van-der-waals TM5 R 220 5x75 s17s18 L 325 C.s17s18.41
Polar TM3 N 122 3x55 s15s16 S 255 C.s15s16.04
Hydrophobic TM3 N 122 3x55 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 N 122 3x55 s15s16 S 255 C.s15s16.04
Hydrophobic ICL1 Q 49 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 Q 49 - s5s6 D 75 N.s5s6.04
Hydrophobic TM6 I 263 6x26 S6 D 86 N.S6.04
Van-der-waals TM6 I 263 6x26 S6 D 86 N.S6.04
Hydrophobic ICL3 F 260 - S6 Y 88 N.S6.06
Polar ICL2 F 126 34x52 S16 Y 259 C.S16.03
Van-der-waals ICL2 F 126 34x52 S16 Y 259 C.S16.03
Hydrophobic ICL2 S 128 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 H 129 34x55 s17s18 G 296 C.s17s18.12
Polar TM5 M 213 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 M 213 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 M 213 5x68 S6 R 85 N.S6.03
Hydrophobic H8 R 333 8x47 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 F 260 - S6 F 89 N.S6.07
Polar ICL2 Y 125 34x51 S16 Y 259 C.S16.03
Aromatic ICL2 Y 125 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 Y 125 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 Y 125 34x51 S16 Y 259 C.S16.03
Hydrophobic TM3 A 120 3x53 S6 F 83 N.S6.01
Hydrophobic TM4 D 132 4x38 s8s9 K 145 N.s8s9.09
Van-der-waals TM4 D 132 4x38 s8s9 K 145 N.s8s9.09
Polar TM5 R 220 5x75 s17s18 T 323 C.s17s18.39
Hydrophobic TM5 R 220 5x75 s17s18 T 323 C.s17s18.39
Van-der-waals TM5 R 220 5x75 s17s18 T 323 C.s17s18.39
Hydrophobic TM2 T 52 2x37 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 T 52 2x37 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 Y 125 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 Y 125 34x51 S8 L 136 N.S8.03
Ionic TM5 R 220 5x75 s17s18 D 321 C.s17s18.37
Hydrophobic TM3 R 117 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 117 3x50 s5s6 I 79 N.s5s6.08
Polar H8 R 333 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 R 333 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 L 210 5x65 s15s16 Y 254 C.s15s16.03
Polar ICL3 R 256 - S6 Y 88 N.S6.06
Hydrophobic ICL3 R 256 - S6 Y 88 N.S6.06
Van-der-waals ICL3 R 256 - S6 Y 88 N.S6.06
Polar ICL2 A 124 34x50 S16 D 257 C.S16.01
Hydrophobic TM3 I 121 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 I 121 3x54 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 I 121 3x54 s15s16 Y 254 C.s15s16.03
Ionic ICL1 R 46 - s5s6 D 75 N.s5s6.04
Polar ICL1 R 46 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 R 46 - s5s6 D 75 N.s5s6.04
Hydrophobic TM5 M 213 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 M 213 5x68 s15s16 Y 254 C.s15s16.03
Polar ICL2 Y 125 34x51 S16 K 261 C.S16.05
Hydrophobic ICL2 Y 125 34x51 S16 K 261 C.S16.05
Van-der-waals ICL2 Y 125 34x51 S16 K 261 C.S16.05
Polar ICL3 R 256 - S6 F 89 N.S6.07
Ionic TM6 R 262 6x25 s9s10 E 164 N.s9s10.06
Polar TM6 R 262 6x25 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 R 262 6x25 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 262 6x25 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 M 270 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 M 270 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 M 270 6x33 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 M 270 6x33 s5s6 G 80 N.s5s6.09
Ionic C-term R 368 - s20c E 405 C.s20c.24
Polar C-term R 368 - s20c E 405 C.s20c.24
Hydrophobic TM2 F 54 2x39 s5s6 I 79 N.s5s6.08
Van-der-waals TM2 F 54 2x39 s5s6 I 79 N.s5s6.08
Polar ICL2 V 131 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 V 131 34x57 s8s9 K 145 N.s8s9.09
Ionic TM3 H 123 3x56 S16 D 257 C.S16.01
Polar TM3 H 123 3x56 S16 D 257 C.S16.01
Hydrophobic TM3 H 123 3x56 S16 D 257 C.S16.01
Van-der-waals TM3 H 123 3x56 S16 D 257 C.S16.01
Ionic TM6 R 262 6x25 s9s10 D 166 N.s9s10.08
Polar TM6 R 262 6x25 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 R 262 6x25 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 R 262 6x25 s9s10 D 166 N.s9s10.08
Hydrophobic ICL3 S 259 - S6 F 89 N.S6.07
Hydrophobic ICL2 Y 125 34x51 S15 V 251 C.S15.14
Polar ICL2 H 129 34x55 S16 K 261 C.S16.05
Ionic ICL1 E 48 - s20c R 398 C.s20c.17
Polar ICL1 E 48 - s20c R 398 C.s20c.17
Hydrophobic ICL2 S 128 34x54 S9 C 147 N.S9.01
Hydrophobic ICL1 E 48 - s5s6 D 75 N.s5s6.04
Van-der-waals ICL1 E 48 - s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 Y 127 34x53 S6 F 83 N.S6.01
Van-der-waals ICL2 Y 127 34x53 S6 F 83 N.S6.01
Hydrophobic TM2 F 54 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 F 54 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 117 3x50 s5s6 V 78 N.s5s6.07
Polar ICL2 H 129 34x55 s17s18 R 295 C.s17s18.11
Aromatic ICL2 H 129 34x55 s17s18 R 295 C.s17s18.11
Hydrophobic ICL2 H 129 34x55 s17s18 R 295 C.s17s18.11
Van-der-waals ICL2 H 129 34x55 s17s18 R 295 C.s17s18.11