Beta-arrestin-2 - FP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
FP 76.7
Beta-arrestin-2 77.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 M 247 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 M 247 6x33 s5s6 G 73 N.s5s6.09
Polar H8 R 308 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 R 308 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 R 308 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL1 K 61 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL1 K 61 - s8s9 E 135 N.s8s9.05
Hydrophobic TM5 V 230 5x66 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 V 230 5x66 s15s16 F 245 C.s15s16.03
Polar ICL1 S 62 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL1 S 62 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL1 S 62 - s5s6 D 68 N.s5s6.04
Polar TM1 Q 60 1x66 s8s9 G 138 N.s8s9.08
Polar ICL2 T 145 34x55 s17s18 R 286 C.s17s18.11
Hydrophobic ICL2 T 145 34x55 s17s18 R 286 C.s17s18.11
Ionic C-term E 334 - s9s10 K 158 N.s9s10.09
Polar C-term E 334 - s9s10 K 158 N.s9s10.09
Hydrophobic C-term E 334 - s9s10 K 158 N.s9s10.09
Van-der-waals C-term E 334 - s9s10 K 158 N.s9s10.09
Aromatic TM6 H 244 6x30 S6 F 76 N.S6.01
Hydrophobic TM6 H 244 6x30 S6 F 76 N.S6.01
Van-der-waals TM6 H 244 6x30 S6 F 76 N.S6.01
Polar ICL1 K 63 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL1 K 63 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL1 K 63 - s5s6 D 68 N.s5s6.04
Hydrophobic TM4 T 148 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 T 148 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM2 F 66 2x39 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 F 66 2x39 s5s6 L 72 N.s5s6.08
Polar ICL2 I 141 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 I 141 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 I 141 34x51 S16 Y 250 C.S16.03
Polar ICL1 S 62 - s8s9 G 138 N.s8s9.08
Polar ICL2 I 147 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 I 147 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 I 147 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 I 141 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 I 141 34x51 S15 I 242 C.S15.14
Hydrophobic TM3 R 133 3x50 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 R 133 3x50 s5s6 L 74 N.s5s6.10
Polar ICL1 S 62 - s5s6 E 67 N.s5s6.03
Ionic TM5 K 233 5x69 s17s18 E 314 C.s17s18.39
Hydrophobic ICL2 T 145 34x55 s17s18 G 287 C.s17s18.12
Hydrophobic TM3 G 136 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 G 136 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 P 140 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 140 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 V 137 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 V 137 3x54 s5s6 L 74 N.s5s6.10
Polar ICL2 H 143 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 H 143 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 H 143 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 H 244 6x30 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 M 247 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 M 247 6x33 s5s6 L 72 N.s5s6.08
Polar ICL2 P 140 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 140 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 140 34x50 S5 Y 64 N.S5.12
Polar TM3 T 138 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 T 138 3x55 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 T 138 3x55 s15s16 S 246 C.s15s16.04
Polar ICL1 S 62 - s8s9 E 135 N.s8s9.05
Polar ICL1 S 62 - s8s9 T 137 N.s8s9.07
Polar ICL1 K 61 - s8s9 T 137 N.s8s9.07
Polar TM2 S 65 2x38 s5s6 R 66 N.s5s6.02
Hydrophobic TM4 T 148 4x38 s17s18 R 286 C.s17s18.11
Van-der-waals TM4 T 148 4x38 s17s18 R 286 C.s17s18.11
Hydrophobic TM2 F 66 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 F 66 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 227 5x63 S6 F 76 N.S6.01
Van-der-waals TM5 L 227 5x63 S6 F 76 N.S6.01
Hydrophobic TM5 L 227 5x63 s5s6 L 74 N.s5s6.10
Polar ICL2 F 142 34x52 S16 Y 250 C.S16.03
Van-der-waals ICL2 F 142 34x52 S16 Y 250 C.S16.03
Polar TM1 R 59 1x65 s20c Y 404 C.s20c.14
Aromatic ICL3 R 238 - S6 F 81 N.S6.06
Hydrophobic ICL3 R 238 - S6 F 81 N.S6.06
Van-der-waals ICL3 R 238 - S6 F 81 N.S6.06
Van-der-waals ICL2 S 144 34x54 s8s9 D 136 N.s8s9.06
Polar TM1 Q 60 1x66 s8s9 T 137 N.s8s9.07
Hydrophobic TM1 Q 60 1x66 s8s9 T 137 N.s8s9.07
Van-der-waals TM1 Q 60 1x66 s8s9 T 137 N.s8s9.07
Hydrophobic TM1 F 58 1x64 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 I 141 34x51 S8 L 130 N.S8.03
Van-der-waals ICL2 I 141 34x51 S8 L 130 N.S8.03
Polar ICL3 R 238 - S6 I 82 N.S6.07
Hydrophobic ICL3 R 238 - S6 I 82 N.S6.07
Van-der-waals ICL3 R 238 - S6 I 82 N.S6.07
Hydrophobic ICL3 R 238 - S6 D 79 N.S6.04
Hydrophobic TM5 S 234 5x70 S6 K 78 N.S6.03
Polar ICL2 S 144 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 S 144 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 S 144 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM2 L 67 2x40 s5s6 V 71 N.s5s6.07
Ionic ICL1 K 63 - s5s6 E 67 N.s5s6.03
Polar ICL1 K 63 - s5s6 E 67 N.s5s6.03
Hydrophobic ICL1 K 63 - s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 K 63 - s5s6 E 67 N.s5s6.03
Hydrophobic ICL1 S 62 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 S 144 34x54 s8s9 A 140 N.s8s9.10
Polar TM2 S 65 2x38 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 V 137 3x54 S6 F 76 N.S6.01
Hydrophobic TM6 M 247 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 M 247 6x33 s5s6 L 74 N.s5s6.10
Polar TM4 S 149 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 S 149 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 I 141 34x51 S16 A 248 C.S16.01
Polar ICL2 I 141 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 I 141 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 I 141 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL1 S 62 - s8s9 D 136 N.s8s9.06
Hydrophobic TM3 R 133 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 133 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 K 63 - s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 I 141 34x51 S9 C 141 N.S9.01