Arrestin-C - IP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
IP 70.1
Arrestin-C 78.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 L 130 34x56 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 L 130 34x56 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 L 130 34x56 s5s6 R 61 N.s5s6.02
Polar ICL2 A 128 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 A 128 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 A 128 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic TM2 F 49 2x39 s5s6 E 65 N.s5s6.06
Van-der-waals ICL2 Y 125 34x51 S15 V 238 C.S15.14
Polar ICL2 L 126 34x52 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 L 126 34x52 s8s9 D 132 N.s8s9.06
Hydrophobic TM3 L 121 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 A 120 3x53 s5s6 L 64 N.s5s6.05
Polar TM6 E 234 6x30 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 E 234 6x30 s15s16 Y 241 C.s15s16.03
Van-der-waals TM6 E 234 6x30 s15s16 Y 241 C.s15s16.03
Polar ICL2 Y 125 34x51 S16 Y 246 C.S16.03
Aromatic ICL2 Y 125 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 Y 125 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 Y 125 34x51 S16 Y 246 C.S16.03
Polar ICL3 R 227 - S6 L 75 N.S6.05
Polar ICL2 P 124 34x50 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 P 124 34x50 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 P 124 34x50 s8s9 G 134 N.s8s9.08
Hydrophobic TM3 H 123 3x56 s8s9 A 133 N.s8s9.07
Van-der-waals TM3 H 123 3x56 s8s9 A 133 N.s8s9.07
Polar ICL2 Y 127 34x53 s5s6 R 61 N.s5s6.02
Aromatic ICL2 Y 127 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 Y 127 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic ICL3 T 230 - S6 K 73 N.S6.03
Hydrophobic TM3 R 117 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 117 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 Q 216 5x69 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 Q 216 5x69 s17s18 E 310 C.s17s18.39
Hydrophobic TM6 H 237 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 H 237 6x33 s5s6 L 69 N.s5s6.10
Polar ICL2 Q 129 34x55 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 Q 129 34x55 s8s9 D 132 N.s8s9.06
Hydrophobic TM5 M 213 5x66 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 M 213 5x66 s15s16 Y 241 C.s15s16.03
Ionic TM5 H 220 5x73 s17s18 E 310 C.s17s18.39
Polar TM5 H 220 5x73 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 H 220 5x73 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 H 220 5x73 s17s18 E 310 C.s17s18.39
Hydrophobic ICL3 L 224 - s17s18 L 311 C.s17s18.40
Van-der-waals ICL3 L 224 - s17s18 L 311 C.s17s18.40
Hydrophobic H8 R 296 8x47 s5s6 G 68 N.s5s6.09
Van-der-waals H8 R 296 8x47 s5s6 G 68 N.s5s6.09
Polar ICL2 Q 129 34x55 s8s9 G 129 N.s8s9.03
Hydrophobic ICL2 Q 129 34x55 s8s9 G 129 N.s8s9.03
Van-der-waals ICL2 Q 129 34x55 s8s9 G 129 N.s8s9.03
Polar ICL2 Q 129 34x55 s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 Q 129 34x55 s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 Q 129 34x55 s8s9 E 131 N.s8s9.05
Polar H8 R 296 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 R 296 8x47 s5s6 V 66 N.s5s6.07
Ionic ICL3 R 229 - s9s10 E 152 N.s9s10.07
Polar ICL3 R 229 - s9s10 E 152 N.s9s10.07
Van-der-waals TM4 P 133 4x39 s5s6 R 61 N.s5s6.02
Van-der-waals TM5 Q 216 5x69 s15s16 Y 241 C.s15s16.03
Ionic ICL2 D 131 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 E 116 3x49 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 E 116 3x49 s5s6 V 66 N.s5s6.07
Polar ICL2 P 124 34x50 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 P 124 34x50 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 P 124 34x50 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 Y 125 34x51 s8s9 P 128 N.s8s9.02
Van-der-waals ICL2 Y 125 34x51 s8s9 P 128 N.s8s9.02
Hydrophobic ICL2 Y 125 34x51 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 Y 125 34x51 s8s9 D 132 N.s8s9.06
Polar TM2 S 47 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic TM2 S 47 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 S 47 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 A 128 34x54 s8s9 P 136 N.s8s9.10
Van-der-waals ICL2 A 128 34x54 s8s9 P 136 N.s8s9.10
Hydrophobic TM3 L 121 3x54 s5s6 L 69 N.s5s6.10
Polar TM3 A 120 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic TM3 A 120 3x53 s8s9 K 135 N.s8s9.09
Van-der-waals TM3 A 120 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 Y 127 34x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 Q 216 5x69 s15s16 L 243 C.s15s16.05
Van-der-waals TM5 Q 216 5x69 s15s16 L 243 C.s15s16.05
Hydrophobic TM5 M 213 5x66 S5 Y 59 N.S5.12
Van-der-waals TM5 M 213 5x66 S5 Y 59 N.S5.12
Hydrophobic ICL2 A 128 34x54 s8s9 P 128 N.s8s9.02
Van-der-waals ICL2 A 128 34x54 s8s9 P 128 N.s8s9.02
Hydrophobic TM6 M 244 6x40 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 Q 217 5x70 S6 K 73 N.S6.03
Hydrophobic ICL3 L 224 - s17s18 D 308 C.s17s18.37
Polar ICL2 Y 125 34x51 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 Y 125 34x51 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 Y 125 34x51 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 P 124 34x50 s8s9 P 136 N.s8s9.10
Van-der-waals ICL2 P 124 34x50 s8s9 P 136 N.s8s9.10
Hydrophobic TM5 V 206 5x59 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 P 124 34x50 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 P 124 34x50 s8s9 K 135 N.s8s9.09
Hydrophobic TM5 L 210 5x63 s5s6 L 69 N.s5s6.10
Polar ICL2 Q 129 34x55 s8s9 P 130 N.s8s9.04
Hydrophobic ICL2 Q 129 34x55 s8s9 P 130 N.s8s9.04
Van-der-waals ICL2 Q 129 34x55 s8s9 P 130 N.s8s9.04
Hydrophobic TM5 L 210 5x63 S6 F 71 N.S6.01
Hydrophobic TM3 R 117 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 117 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 M 213 5x66 S6 F 71 N.S6.01
Van-der-waals TM5 M 213 5x66 S6 F 71 N.S6.01
Polar TM6 H 237 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 H 237 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 H 237 6x33 s5s6 I 67 N.s5s6.08
Hydrophobic TM3 L 121 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 L 121 3x54 S6 F 71 N.S6.01
Hydrophobic TM6 L 240 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 F 49 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 F 49 2x39 s5s6 V 66 N.s5s6.07
Polar ICL2 Y 125 34x51 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 Y 125 34x51 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 Y 125 34x51 s8s9 A 133 N.s8s9.07
Polar ICL2 Y 125 34x51 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 Y 125 34x51 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 Y 125 34x51 s8s9 K 135 N.s8s9.09
Hydrophobic ICL1 R 45 - s20c V 380 C.s20c.13
Ionic TM5 H 220 5x73 s17s18 D 308 C.s17s18.37
Polar TM5 H 220 5x73 s17s18 D 308 C.s17s18.37
Hydrophobic TM5 H 220 5x73 s17s18 D 308 C.s17s18.37
Van-der-waals TM5 H 220 5x73 s17s18 D 308 C.s17s18.37
Polar TM5 Q 217 5x70 s17s18 E 310 C.s17s18.39
Polar H8 R 296 8x47 s5s6 I 67 N.s5s6.08
Hydrophobic H8 R 296 8x47 s5s6 I 67 N.s5s6.08
Van-der-waals H8 R 296 8x47 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 Y 125 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 Y 125 34x51 S16 D 244 C.S16.01
Polar H8 R 296 8x47 s5s6 E 65 N.s5s6.06
Van-der-waals H8 R 296 8x47 s5s6 E 65 N.s5s6.06