Arrestin-C - PKR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
PKR1 72.4
Arrestin-C 81.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 17.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 P 169 - s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 P 169 - s8s9 K 135 N.s8s9.09
Hydrophobic TM6 I 272 6x23 S6 L 75 N.S6.05
Van-der-waals TM6 I 272 6x23 S6 L 75 N.S6.05
Polar TM6 R 279 6x30 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 R 162 3x50 s5s6 V 66 N.s5s6.07
Polar TM6 R 279 6x30 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 R 279 6x30 s5s6 T 70 N.s5s6.11
Hydrophobic ICL2 L 170 - S15 V 238 C.S15.14
Hydrophobic TM6 T 282 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 F 267 5x73 s17s18 L 311 C.s17s18.40
Hydrophobic TM3 A 165 3x53 S6 F 71 N.S6.01
Van-der-waals TM3 A 165 3x53 S6 F 71 N.S6.01
Ionic TM6 R 275 6x26 S6 D 74 N.S6.04
Polar TM6 R 275 6x26 S6 D 74 N.S6.04
Hydrophobic TM6 R 275 6x26 S6 D 74 N.S6.04
Van-der-waals TM6 R 275 6x26 S6 D 74 N.S6.04
Hydrophobic TM5 G 266 5x72 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 G 266 5x72 s17s18 L 311 C.s17s18.40
Hydrophobic TM5 F 267 5x73 S6 Y 76 N.S6.06
Hydrophobic TM5 F 267 5x73 s7s8 V 117 N.s7s8.03
Van-der-waals TM5 F 267 5x73 s7s8 V 117 N.s7s8.03
Hydrophobic ICL2 L 170 - S5 Y 59 N.S5.12
Van-der-waals ICL2 L 170 - S5 Y 59 N.S5.12
Hydrophobic TM6 Q 271 6x22 S6 V 77 N.S6.07
Van-der-waals TM6 Q 271 6x22 S6 V 77 N.S6.07
Polar TM6 R 279 6x30 S6 R 72 N.S6.02
Van-der-waals TM6 R 279 6x30 S6 R 72 N.S6.02
Polar ICL2 R 173 - s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 R 173 - s5s6 L 64 N.s5s6.05
Van-der-waals ICL2 R 173 - s5s6 L 64 N.s5s6.05
Hydrophobic TM5 P 265 5x71 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 P 265 5x71 s15s16 L 240 C.s15s16.02
Ionic TM6 K 274 6x25 s9s10 E 152 N.s9s10.07
Polar TM6 K 274 6x25 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 K 274 6x25 s9s10 E 152 N.s9s10.07
Van-der-waals TM6 K 274 6x25 s9s10 E 152 N.s9s10.07
Hydrophobic TM3 D 161 3x49 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 D 161 3x49 s5s6 V 66 N.s5s6.07
Polar TM2 T 97 2x39 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 T 97 2x39 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 T 97 2x39 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 F 267 5x73 s7s8 L 120 N.s7s8.06
Van-der-waals TM5 F 267 5x73 s7s8 L 120 N.s7s8.06
Hydrophobic TM5 V 264 5x70 S6 K 73 N.S6.03
Hydrophobic TM5 P 265 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic C-term L 392 - H1 K 104 N.H1.09
Van-der-waals C-term L 392 - H1 K 104 N.H1.09
Hydrophobic TM3 I 158 3x46 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 158 3x46 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 P 169 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 169 - s15s16 Y 241 C.s15s16.03
Polar ICL3 T 269 - S6 V 77 N.S6.07
Hydrophobic ICL3 T 269 - S6 V 77 N.S6.07
Van-der-waals ICL3 T 269 - S6 V 77 N.S6.07
Polar ICL2 R 171 - s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 R 171 - s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 R 171 - s8s9 K 135 N.s8s9.09
Hydrophobic TM5 L 259 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 170 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 L 170 - s15s16 S 242 C.s15s16.04
Hydrophobic TM3 A 165 3x53 s5s6 V 66 N.s5s6.07
Polar ICL2 L 170 - s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 L 170 - s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 L 170 - s8s9 K 135 N.s8s9.09
Polar H8 K 351 8x51 s9s10 T 154 N.s9s10.09
Van-der-waals H8 K 351 8x51 s9s10 T 154 N.s9s10.09
Hydrophobic TM3 R 162 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 162 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 G 266 5x72 S6 L 75 N.S6.05
Van-der-waals TM5 G 266 5x72 S6 L 75 N.S6.05
Hydrophobic TM5 F 267 5x73 s7s8 N 119 N.s7s8.05
Hydrophobic TM6 Q 271 6x22 S5 M 52 N.S5.05
Hydrophobic TM6 I 272 6x23 S6 Y 76 N.S6.06
Van-der-waals TM6 I 272 6x23 S6 Y 76 N.S6.06
Polar TM6 Q 271 6x22 S6 T 79 N.S6.09
Hydrophobic TM6 Q 271 6x22 S6 T 79 N.S6.09
Van-der-waals TM6 Q 271 6x22 S6 T 79 N.S6.09
Hydrophobic ICL2 P 172 - s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 P 172 - s8s9 K 135 N.s8s9.09
Hydrophobic TM6 I 272 6x23 S6 D 74 N.S6.04
Van-der-waals TM6 I 272 6x23 S6 D 74 N.S6.04
Hydrophobic ICL2 P 169 - S5 Y 59 N.S5.12
Van-der-waals ICL2 P 169 - S5 Y 59 N.S5.12
Aromatic ICL2 R 173 - S6 F 71 N.S6.01
Hydrophobic ICL2 R 173 - S6 F 71 N.S6.01
Van-der-waals ICL2 R 173 - S6 F 71 N.S6.01
Van-der-waals ICL2 P 172 - s8s9 A 133 N.s8s9.07
Hydrophobic TM2 I 101 2x43 s5s6 I 67 N.s5s6.08
Polar ICL2 R 173 - s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 R 173 - s5s6 E 65 N.s5s6.06
Polar ICL4 K 346 - s5s6 I 67 N.s5s6.08
Hydrophobic ICL4 K 346 - s5s6 I 67 N.s5s6.08
Van-der-waals ICL4 K 346 - s5s6 I 67 N.s5s6.08
Hydrophobic TM3 I 166 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 166 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 170 - S9 C 137 N.S9.01
Hydrophobic TM5 P 265 5x71 S6 K 73 N.S6.03
Van-der-waals TM5 P 265 5x71 S6 K 73 N.S6.03
Hydrophobic TM2 T 97 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 T 97 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 P 265 5x71 S6 L 75 N.S6.05
Van-der-waals TM5 P 265 5x71 S6 L 75 N.S6.05
Hydrophobic TM6 R 279 6x30 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 R 279 6x30 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 R 173 - s5s6 V 66 N.s5s6.07
Van-der-waals ICL2 R 173 - s5s6 V 66 N.s5s6.07
Hydrophobic TM5 P 265 5x71 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 P 265 5x71 s17s18 L 311 C.s17s18.40
Hydrophobic TM6 I 272 6x23 S6 V 77 N.S6.07
Hydrophobic ICL3 T 269 - S6 Y 76 N.S6.06
Van-der-waals ICL3 T 269 - S6 Y 76 N.S6.06
Polar TM5 F 267 5x73 S6 L 75 N.S6.05
Van-der-waals TM5 F 267 5x73 S6 L 75 N.S6.05