S-arrestin - PKR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
PKR1 71.4
S-arrestin 80.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 172 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 P 172 - s8s9 D 142 N.s8s9.06
Hydrophobic TM3 A 165 3x53 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 F 342 7x53 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 F 342 7x53 s5s6 I 79 N.s5s6.08
Ionic ICL1 K 92 12x49 s20c D 402 C.s20c.21
Polar ICL1 K 92 12x49 s20c D 402 C.s20c.21
Van-der-waals ICL1 K 92 12x49 s20c D 402 C.s20c.21
Hydrophobic TM3 R 162 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 162 3x50 s5s6 I 79 N.s5s6.08
Polar ICL2 L 170 - S5 Y 71 N.S5.12
Hydrophobic ICL2 L 170 - S5 Y 71 N.S5.12
Van-der-waals ICL2 L 170 - S5 Y 71 N.S5.12
Polar TM5 P 265 5x71 S6 R 85 N.S6.03
Hydrophobic TM5 P 265 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 P 265 5x71 S6 R 85 N.S6.03
Ionic ICL4 K 346 - s5s6 D 77 N.s5s6.06
Polar ICL4 K 346 - s5s6 D 77 N.s5s6.06
Hydrophobic ICL4 K 346 - s5s6 D 77 N.s5s6.06
Van-der-waals ICL4 K 346 - s5s6 D 77 N.s5s6.06
Hydrophobic TM6 T 282 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 T 282 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 L 170 - S8 L 136 N.S8.03
Hydrophobic TM2 T 97 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 T 97 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 A 165 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 165 3x53 S6 F 83 N.S6.01
Ionic TM6 R 275 6x26 s9s10 E 165 N.s9s10.07
Polar TM6 R 275 6x26 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 275 6x26 s9s10 E 165 N.s9s10.07
Polar TM6 T 282 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 T 282 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 V 264 5x70 S6 R 85 N.S6.03
Van-der-waals TM5 V 264 5x70 S6 R 85 N.S6.03
Ionic TM6 R 275 6x26 S6 D 86 N.S6.04
Polar TM6 R 275 6x26 S6 D 86 N.S6.04
Hydrophobic TM6 R 275 6x26 S6 D 86 N.S6.04
Van-der-waals TM6 R 275 6x26 S6 D 86 N.S6.04
Hydrophobic TM5 G 266 5x72 s17s18 V 324 C.s17s18.40
Van-der-waals TM5 G 266 5x72 s17s18 V 324 C.s17s18.40
Hydrophobic ICL2 L 170 - S9 C 147 N.S9.01
Van-der-waals ICL2 L 170 - S9 C 147 N.S9.01
Hydrophobic TM5 L 259 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 L 259 5x65 s5s6 L 81 N.s5s6.10
Polar TM6 R 279 6x30 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 R 279 6x30 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 R 279 6x30 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 R 279 6x30 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 R 279 6x30 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 I 166 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 166 3x54 S6 F 83 N.S6.01
Van-der-waals ICL2 L 170 - s15s16 S 255 C.s15s16.04
Polar TM5 F 267 5x73 S6 L 87 N.S6.05
Polar ICL2 P 169 - S5 Y 71 N.S5.12
Hydrophobic ICL2 P 169 - S5 Y 71 N.S5.12
Van-der-waals ICL2 P 169 - S5 Y 71 N.S5.12
Hydrophobic ICL2 R 173 - s5s6 V 78 N.s5s6.07
Van-der-waals ICL2 R 173 - s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 R 171 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 171 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 L 170 - S16 D 257 C.S16.01
Van-der-waals ICL2 L 170 - S16 D 257 C.S16.01
Polar TM5 K 262 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 K 262 5x68 s15s16 Y 254 C.s15s16.03
Polar ICL2 R 173 - s5s6 D 75 N.s5s6.04
Polar ICL2 L 170 - S16 Y 259 C.S16.03
Hydrophobic ICL2 L 170 - S16 Y 259 C.S16.03
Van-der-waals ICL2 L 170 - S16 Y 259 C.S16.03
Hydrophobic TM5 P 265 5x71 s17s18 T 323 C.s17s18.39
Van-der-waals TM5 P 265 5x71 s17s18 T 323 C.s17s18.39
Hydrophobic ICL4 K 346 - s5s6 I 79 N.s5s6.08
Ionic H8 K 355 8x55 s20c E 405 C.s20c.24
Polar H8 K 355 8x55 s20c E 405 C.s20c.24
Hydrophobic TM6 Q 271 6x22 S6 F 89 N.S6.07
Van-der-waals TM6 Q 271 6x22 S6 F 89 N.S6.07
Hydrophobic ICL2 L 170 - S15 V 251 C.S15.14
Van-der-waals ICL2 L 170 - S15 V 251 C.S15.14
Hydrophobic TM5 F 267 5x73 s7s8 Y 129 N.s7s8.05
Van-der-waals TM5 F 267 5x73 s7s8 Y 129 N.s7s8.05
Polar ICL2 L 170 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 L 170 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 L 170 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 R 173 - s5s6 I 76 N.s5s6.05
Van-der-waals ICL2 R 173 - s5s6 I 76 N.s5s6.05
Hydrophobic TM6 I 272 6x23 S6 D 86 N.S6.04
Van-der-waals TM6 I 272 6x23 S6 D 86 N.S6.04
Hydrophobic TM5 P 265 5x71 s17s18 V 324 C.s17s18.40
Van-der-waals TM5 P 265 5x71 s17s18 V 324 C.s17s18.40
Hydrophobic ICL2 P 169 - S6 F 83 N.S6.01
Hydrophobic TM3 A 165 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 P 169 - s15s16 Y 254 C.s15s16.03
Polar TM3 R 162 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 162 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 162 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 I 166 3x54 s5s6 L 81 N.s5s6.10
Polar TM6 R 275 6x26 S6 R 84 N.S6.02
Hydrophobic TM6 R 275 6x26 S6 R 84 N.S6.02
Van-der-waals TM6 R 275 6x26 S6 R 84 N.S6.02
Polar TM2 N 95 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM6 I 272 6x23 S6 L 87 N.S6.05
Hydrophobic ICL2 P 172 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 P 172 - s8s9 K 145 N.s8s9.09