Beta-arrestin-1 - PKR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
PKR2 74.8
Beta-arrestin-1 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 E 249 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 E 249 5x64 s15s16 F 244 C.s15s16.03
Polar TM5 P 256 5x71 S6 K 77 N.S6.03
Hydrophobic TM5 P 256 5x71 S6 K 77 N.S6.03
Van-der-waals TM5 P 256 5x71 S6 K 77 N.S6.03
Hydrophobic TM3 A 156 3x53 s5s6 V 70 N.s5s6.07
Ionic C-term E 376 - s8s9 K 138 N.s8s9.09
Hydrophobic C-term V 372 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term V 372 - s9s10 K 160 N.s9s10.12
Ionic C-term D 379 - s9s10 K 157 N.s9s10.09
Polar C-term D 379 - s9s10 K 157 N.s9s10.09
Polar TM6 R 270 6x30 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 R 270 6x30 s5s6 T 74 N.s5s6.11
Polar TM6 R 270 6x30 S5 Y 63 N.S5.12
Hydrophobic TM6 R 270 6x30 S5 Y 63 N.S5.12
Van-der-waals TM6 R 270 6x30 S5 Y 63 N.S5.12
Hydrophobic TM3 A 156 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 A 156 3x53 s5s6 L 68 N.s5s6.05
Polar TM3 V 158 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 V 158 3x55 s15s16 N 245 C.s15s16.04
Ionic TM6 R 266 6x26 S6 D 78 N.S6.04
Polar TM6 R 266 6x26 S6 D 78 N.S6.04
Hydrophobic TM6 R 266 6x26 S6 D 78 N.S6.04
Van-der-waals TM6 R 266 6x26 S6 D 78 N.S6.04
Polar C-term P 373 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term P 373 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term P 373 - s9s10 K 160 N.s9s10.12
Hydrophobic ICL2 R 164 - s5s6 R 65 N.s5s6.02
Hydrophobic TM6 I 263 6x23 S6 D 78 N.S6.04
Hydrophobic TM2 T 88 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 T 88 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 P 160 - s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 164 - s5s6 L 68 N.s5s6.05
Van-der-waals ICL2 R 164 - s5s6 L 68 N.s5s6.05
Polar TM5 K 253 5x68 s15s16 F 244 C.s15s16.03
Aromatic TM5 K 253 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 K 253 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 K 253 5x68 s15s16 F 244 C.s15s16.03
Polar TM6 R 266 6x26 S6 R 76 N.S6.02
Hydrophobic TM6 R 266 6x26 S6 R 76 N.S6.02
Hydrophobic TM3 A 156 3x53 S6 F 75 N.S6.01
Polar TM3 H 159 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic C-term E 376 - s5s6 E 66 N.s5s6.03
Van-der-waals C-term E 376 - s5s6 E 66 N.s5s6.03
Hydrophobic ICL2 P 163 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 P 163 - s17s18 R 285 C.s17s18.11
Polar TM6 T 273 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 273 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 273 6x33 s5s6 L 71 N.s5s6.08
Polar C-term N 370 - s9s10 R 161 N.s9s10.13
Van-der-waals C-term N 370 - s9s10 R 161 N.s9s10.13
Hydrophobic TM6 R 270 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 R 270 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 L 277 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 277 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 157 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 P 160 - s15s16 F 244 C.s15s16.03
Polar ICL4 K 337 - s5s6 V 70 N.s5s6.07
Hydrophobic ICL4 K 337 - s5s6 V 70 N.s5s6.07
Van-der-waals ICL4 K 337 - s5s6 V 70 N.s5s6.07
Hydrophobic ICL4 K 337 - s5s6 L 71 N.s5s6.08
Van-der-waals ICL4 K 337 - s5s6 L 71 N.s5s6.08
Hydrophobic C-term T 374 - s9s10 K 157 N.s9s10.09
Hydrophobic C-term V 378 - s5s6 G 72 N.s5s6.09
Van-der-waals C-term V 378 - s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 P 160 - S5 Y 63 N.S5.12
Hydrophobic ICL2 P 160 - S6 F 75 N.S6.01
Ionic C-term E 377 - s9s10 K 157 N.s9s10.09
Polar C-term E 377 - s9s10 K 157 N.s9s10.09
Hydrophobic C-term E 377 - s9s10 K 157 N.s9s10.09
Van-der-waals C-term E 377 - s9s10 K 157 N.s9s10.09
Polar C-term T 369 - s9s10 R 161 N.s9s10.13
Hydrophobic C-term T 369 - s9s10 R 161 N.s9s10.13
Van-der-waals C-term T 369 - s9s10 R 161 N.s9s10.13
Ionic ICL1 K 83 12x49 s20c E 407 C.s20c.17
Polar ICL1 K 83 12x49 s20c E 407 C.s20c.17
Hydrophobic ICL1 K 83 12x49 s20c E 407 C.s20c.17
Van-der-waals ICL1 K 83 12x49 s20c E 407 C.s20c.17
Hydrophobic C-term T 374 - s9s10 K 160 N.s9s10.12
Hydrophobic ICL2 L 161 - S9 C 140 N.S9.01
Van-der-waals ICL2 L 161 - S9 C 140 N.S9.01
Hydrophobic ICL2 L 161 - S16 A 247 C.S16.01
Van-der-waals ICL2 L 161 - S16 A 247 C.S16.01
Polar ICL2 R 164 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 164 - s5s6 D 67 N.s5s6.04
Hydrophobic TM3 I 157 3x54 S6 F 75 N.S6.01
Polar C-term T 375 - s9s10 I 158 N.s9s10.10
Hydrophobic C-term T 375 - s9s10 I 158 N.s9s10.10
Van-der-waals C-term T 375 - s9s10 I 158 N.s9s10.10
Hydrophobic C-term V 372 - s9s10 R 161 N.s9s10.13
Van-der-waals C-term V 372 - s9s10 R 161 N.s9s10.13
Hydrophobic C-term T 375 - s9s10 H 159 N.s9s10.11
Hydrophobic ICL2 L 161 - s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 161 - s15s16 N 245 C.s15s16.04
Hydrophobic TM3 R 153 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 273 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 R 153 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 153 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic C-term T 375 - s9s10 K 160 N.s9s10.12
Van-der-waals C-term T 375 - s9s10 K 160 N.s9s10.12
Hydrophobic C-term V 378 - s5s6 T 74 N.s5s6.11
Van-der-waals C-term V 378 - s5s6 T 74 N.s5s6.11
Van-der-waals TM3 I 157 3x54 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 L 250 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 250 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 I 157 3x54 s5s6 L 73 N.s5s6.10
Polar ICL2 L 161 - S16 Y 249 C.S16.03
Hydrophobic ICL2 L 161 - S16 Y 249 C.S16.03
Van-der-waals ICL2 L 161 - S16 Y 249 C.S16.03
Hydrophobic ICL2 R 164 - s5s6 V 70 N.s5s6.07
Van-der-waals ICL2 R 164 - s5s6 V 70 N.s5s6.07
Aromatic TM6 R 270 6x30 S6 F 75 N.S6.01
Hydrophobic TM5 V 255 5x70 S6 K 77 N.S6.03
Van-der-waals TM5 V 255 5x70 S6 K 77 N.S6.03
Hydrophobic C-term T 375 - S10 R 165 N.S10.03
Van-der-waals C-term T 375 - S10 R 165 N.S10.03
Hydrophobic ICL2 L 161 - S15 I 241 C.S15.14
Van-der-waals ICL2 L 161 - S15 I 241 C.S15.14