S-arrestin - PKR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
PKR2 74.0
S-arrestin 82.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 17.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 163 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 P 163 - s8s9 K 145 N.s8s9.09
Polar ICL4 K 337 - s5s6 I 79 N.s5s6.08
Hydrophobic ICL4 K 337 - s5s6 I 79 N.s5s6.08
Van-der-waals ICL4 K 337 - s5s6 I 79 N.s5s6.08
Polar TM6 R 270 6x30 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 R 270 6x30 s15s16 Y 254 C.s15s16.03
Hydrophobic TM2 T 88 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 T 88 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 I 157 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 I 157 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 P 256 5x71 S6 L 87 N.S6.05
Van-der-waals TM5 P 256 5x71 S6 L 87 N.S6.05
Ionic TM6 R 266 6x26 S6 D 86 N.S6.04
Polar TM6 R 266 6x26 S6 D 86 N.S6.04
Hydrophobic TM6 R 266 6x26 S6 D 86 N.S6.04
Van-der-waals TM6 R 266 6x26 S6 D 86 N.S6.04
Polar ICL2 L 161 - S16 Y 259 C.S16.03
Hydrophobic ICL2 L 161 - S16 Y 259 C.S16.03
Polar TM5 F 258 5x73 S6 L 87 N.S6.05
Ionic TM6 K 265 6x25 s9s10 D 162 N.s9s10.04
Hydrophobic TM6 T 273 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 T 273 6x33 s5s6 L 81 N.s5s6.10
Polar TM5 K 253 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 K 253 5x68 s15s16 Y 254 C.s15s16.03
Polar TM5 A 254 5x69 S6 R 85 N.S6.03
Hydrophobic TM5 A 254 5x69 S6 R 85 N.S6.03
Van-der-waals TM5 A 254 5x69 S6 R 85 N.S6.03
Polar TM6 T 273 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 T 273 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 A 156 3x53 s5s6 V 78 N.s5s6.07
Polar TM6 R 270 6x30 S5 Y 71 N.S5.12
Van-der-waals TM6 R 270 6x30 S5 Y 71 N.S5.12
Polar ICL2 L 161 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 L 161 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 L 161 - s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 L 161 - S5 Y 71 N.S5.12
Polar TM6 R 270 6x30 S6 R 84 N.S6.02
Hydrophobic TM6 R 270 6x30 S6 R 84 N.S6.02
Van-der-waals TM6 R 270 6x30 S6 R 84 N.S6.02
Hydrophobic TM6 I 263 6x23 S6 D 86 N.S6.04
Van-der-waals TM6 I 263 6x23 S6 D 86 N.S6.04
Hydrophobic ICL3 T 260 - S6 Y 88 N.S6.06
Hydrophobic ICL2 L 161 - S15 V 251 C.S15.14
Van-der-waals ICL2 L 161 - S15 V 251 C.S15.14
Hydrophobic ICL2 L 161 - S16 D 257 C.S16.01
Hydrophobic TM6 R 266 6x26 S6 R 84 N.S6.02
Van-der-waals TM6 R 266 6x26 S6 R 84 N.S6.02
Polar TM6 R 270 6x30 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 R 270 6x30 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 Q 262 6x22 S6 F 89 N.S6.07
Van-der-waals TM6 Q 262 6x22 S6 F 89 N.S6.07
Polar ICL2 P 160 - s5s6 G 72 N.s5s6.01
Hydrophobic TM3 A 156 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 156 3x53 S6 F 83 N.S6.01
Hydrophobic TM3 I 157 3x54 S6 F 83 N.S6.01
Hydrophobic ICL2 R 164 - s5s6 I 76 N.s5s6.05
Van-der-waals ICL2 R 164 - s5s6 I 76 N.s5s6.05
Hydrophobic TM5 P 256 5x71 s17s18 V 324 C.s17s18.40
Van-der-waals TM5 P 256 5x71 s17s18 V 324 C.s17s18.40
Ionic H8 K 346 8x55 s20c E 405 C.s20c.24
Polar H8 K 346 8x55 s20c E 405 C.s20c.24
Hydrophobic H8 K 346 8x55 s20c E 405 C.s20c.24
Van-der-waals H8 K 346 8x55 s20c E 405 C.s20c.24
Polar TM2 T 88 2x39 s5s6 D 77 N.s5s6.06
Ionic ICL1 K 83 12x49 s20c D 402 C.s20c.21
Polar ICL1 K 83 12x49 s20c D 402 C.s20c.21
Van-der-waals ICL1 K 83 12x49 s20c D 402 C.s20c.21
Hydrophobic ICL2 R 164 - S6 F 83 N.S6.01
Van-der-waals ICL2 R 164 - S6 F 83 N.S6.01
Polar TM2 N 86 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 L 161 - S9 C 147 N.S9.01
Van-der-waals ICL2 L 161 - S9 C 147 N.S9.01
Hydrophobic TM6 L 277 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 277 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 P 163 - s8s9 D 142 N.s8s9.06
Van-der-waals ICL2 P 163 - s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 P 160 - s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 I 263 6x23 S6 L 87 N.S6.05
Van-der-waals TM6 I 263 6x23 S6 L 87 N.S6.05
Hydrophobic TM6 R 270 6x30 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 K 162 - s8s9 K 145 N.s8s9.09
Hydrophobic TM6 Q 262 6x22 s9s10 A 163 N.s9s10.05
Van-der-waals TM6 Q 262 6x22 s9s10 A 163 N.s9s10.05
Hydrophobic TM3 R 153 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 153 3x50 s5s6 V 78 N.s5s6.07
Polar ICL1 K 83 12x49 s20c N 401 C.s20c.20
Polar TM5 K 253 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 K 253 5x68 S6 R 85 N.S6.03
Ionic TM6 R 266 6x26 s9s10 E 165 N.s9s10.07
Polar TM6 R 266 6x26 s9s10 E 165 N.s9s10.07
Hydrophobic TM6 R 266 6x26 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 266 6x26 s9s10 E 165 N.s9s10.07
Hydrophobic TM3 R 153 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 153 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 L 161 - s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 L 161 - s15s16 S 255 C.s15s16.04
Hydrophobic TM5 V 255 5x70 S6 R 85 N.S6.03
Van-der-waals TM5 V 255 5x70 S6 R 85 N.S6.03
Aromatic TM5 F 258 5x73 s7s8 Y 129 N.s7s8.05
Hydrophobic TM5 F 258 5x73 s7s8 Y 129 N.s7s8.05
Van-der-waals TM5 F 258 5x73 s7s8 Y 129 N.s7s8.05
Hydrophobic TM5 P 256 5x71 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 P 256 5x71 s15s16 L 253 C.s15s16.02
Hydrophobic ICL2 P 160 - S5 Y 71 N.S5.12
Van-der-waals ICL2 P 160 - S5 Y 71 N.S5.12
Hydrophobic TM5 G 257 5x72 s17s18 V 324 C.s17s18.40
Van-der-waals TM5 G 257 5x72 s17s18 V 324 C.s17s18.40
Hydrophobic TM3 I 157 3x54 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 I 263 6x23 S6 Y 88 N.S6.06
Hydrophobic TM5 P 256 5x71 s17s18 T 323 C.s17s18.39
Van-der-waals TM5 P 256 5x71 s17s18 T 323 C.s17s18.39
Hydrophobic TM5 P 256 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 P 256 5x71 S6 R 85 N.S6.03
Hydrophobic TM5 L 250 5x65 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 R 164 - s5s6 V 78 N.s5s6.07
Van-der-waals ICL2 R 164 - s5s6 V 78 N.s5s6.07