Beta-arrestin-1 - PrRP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
PrRP 76.0
Beta-arrestin-1 80.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic ICL1 R 90 12x49 s20c E 405 C.s20c.15
Polar ICL1 R 90 12x49 s20c E 405 C.s20c.15
Hydrophobic ICL1 R 90 12x49 s20c E 405 C.s20c.15
Van-der-waals ICL1 R 90 12x49 s20c E 405 C.s20c.15
Hydrophobic TM5 P 258 5x71 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 L 167 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 L 167 34x51 S16 A 247 C.S16.01
Hydrophobic TM6 R 272 6x29 s5s6 L 73 N.s5s6.10
Polar TM5 P 258 5x71 S6 D 78 N.S6.04
Polar TM5 R 255 5x68 S6 R 76 N.S6.02
Van-der-waals TM5 R 255 5x68 S6 R 76 N.S6.02
Hydrophobic TM5 V 256 5x69 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 V 256 5x69 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 R 170 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 R 170 - s5s6 R 65 N.s5s6.02
Hydrophobic TM3 R 159 3x50 s5s6 L 71 N.s5s6.08
Polar TM5 K 251 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 K 251 5x64 s15s16 F 244 C.s15s16.03
Polar TM5 G 259 5x72 S6 D 78 N.S6.04
Hydrophobic TM5 G 259 5x72 S6 D 78 N.S6.04
Van-der-waals TM5 G 259 5x72 S6 D 78 N.S6.04
Ionic ICL2 R 170 - s5s6 D 67 N.s5s6.04
Polar ICL2 R 170 - s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 R 170 - s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 170 - s5s6 D 67 N.s5s6.04
Van-der-waals TM6 W 268 6x25 s9s10 K 157 N.s9s10.09
Hydrophobic TM2 I 99 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 L 163 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 L 163 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM4 S 172 4x38 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 S 172 4x38 s8s9 E 134 N.s8s9.05
Polar H8 S 341 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic H8 S 341 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 341 8x49 s5s6 D 69 N.s5s6.06
Ionic H8 K 348 8x56 s20c E 405 C.s20c.15
Polar H8 K 348 8x56 s20c E 405 C.s20c.15
Hydrophobic TM5 P 258 5x71 S6 K 77 N.S6.03
Van-der-waals TM5 P 258 5x71 S6 K 77 N.S6.03
Polar ICL2 P 166 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 166 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 166 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 167 34x51 S9 C 140 N.S9.01
Hydrophobic TM2 T 95 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 L 163 3x54 S6 F 75 N.S6.01
Hydrophobic TM3 L 163 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 L 163 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 L 167 34x51 S8 L 129 N.S8.03
Hydrophobic TM5 R 255 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 255 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic ICL3 V 261 - S6 V 81 N.S6.07
Van-der-waals ICL3 V 261 - S6 V 81 N.S6.07
Polar H8 H 339 8x47 s5s6 L 71 N.s5s6.08
Hydrophobic H8 H 339 8x47 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 L 163 3x54 s5s6 L 73 N.s5s6.10
Polar H8 H 339 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 H 339 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 V 162 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM2 N 93 2x37 s5s6 D 67 N.s5s6.04
Polar TM6 T 276 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 276 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 276 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 252 5x65 S6 F 75 N.S6.01
Ionic ICL2 R 169 34x53 s8s9 E 134 N.s8s9.05
Polar ICL2 R 169 34x53 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 169 34x53 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 R 169 34x53 s8s9 E 134 N.s8s9.05
Polar ICL2 L 167 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 167 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 167 34x51 S16 Y 249 C.S16.03
Hydrophobic TM5 L 252 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 252 5x65 s5s6 L 73 N.s5s6.10
Polar H8 H 339 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic H8 H 339 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 H 339 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 L 167 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 L 167 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 T 276 6x33 s5s6 L 73 N.s5s6.10
Polar ICL2 L 167 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 L 167 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 167 34x51 S5 Y 63 N.S5.12
Hydrophobic TM6 L 280 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 280 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 R 255 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 R 255 5x68 S6 F 75 N.S6.01
Hydrophobic ICL2 L 167 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 L 167 34x51 S15 I 241 C.S15.14
Polar TM6 R 272 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 R 272 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 R 272 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic ICL2 R 169 34x53 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 R 169 34x53 s17s18 R 285 C.s17s18.11
Polar TM3 R 159 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 159 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 L 279 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 V 248 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic H8 E 344 8x52 s20c D 408 C.s20c.18
Polar TM6 R 272 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 R 272 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 R 272 6x29 s5s6 G 72 N.s5s6.09
Polar TM5 R 255 5x68 s5s6 T 74 N.s5s6.11