Beta-arrestin-2 - PrRP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
PrRP 75.5
Beta-arrestin-2 79.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic ICL2 R 169 34x53 s8s9 E 135 N.s8s9.05
Polar ICL2 R 169 34x53 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 R 169 34x53 s8s9 E 135 N.s8s9.05
Polar ICL2 L 167 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 167 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 167 34x51 S16 Y 250 C.S16.03
Hydrophobic TM5 P 258 5x71 s15s16 L 244 C.s15s16.02
Van-der-waals TM5 P 258 5x71 s15s16 L 244 C.s15s16.02
Hydrophobic ICL3 Q 265 - S6 I 82 N.S6.07
Van-der-waals ICL3 Q 265 - S6 I 82 N.S6.07
Polar TM6 R 272 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 R 272 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 272 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic ICL2 R 169 34x53 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 R 169 34x53 s17s18 R 286 C.s17s18.11
Hydrophobic TM5 P 258 5x71 S6 K 78 N.S6.03
Van-der-waals TM5 P 258 5x71 S6 K 78 N.S6.03
Polar TM6 R 272 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 R 272 6x29 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 R 272 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 T 276 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 T 276 6x33 s5s6 L 74 N.s5s6.10
Polar TM5 R 255 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 R 255 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 R 255 5x68 S6 F 76 N.S6.01
Hydrophobic TM3 R 159 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM7 L 338 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 L 338 7x56 s5s6 V 71 N.s5s6.07
Polar ICL3 Q 265 - S6 D 79 N.S6.04
Hydrophobic ICL3 Q 265 - S6 D 79 N.S6.04
Van-der-waals ICL3 Q 265 - S6 D 79 N.S6.04
Hydrophobic ICL2 L 167 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 167 34x51 S15 I 242 C.S15.14
Polar TM4 L 173 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 L 252 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 252 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 L 163 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 163 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 L 280 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 L 167 34x51 S9 C 141 N.S9.01
Hydrophobic ICL2 L 167 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 167 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 167 34x51 S8 L 130 N.S8.03
Hydrophobic H8 H 339 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 H 339 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 L 252 5x65 S6 F 76 N.S6.01
Van-der-waals TM5 L 252 5x65 S6 F 76 N.S6.01
Van-der-waals TM3 V 162 3x53 s5s6 D 68 N.s5s6.04
Polar ICL2 P 166 34x50 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 P 166 34x50 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 V 162 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 162 3x53 s5s6 L 69 N.s5s6.05
Ionic ICL2 R 170 - s5s6 D 68 N.s5s6.04
Polar ICL2 R 170 - s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 170 - s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 170 - s5s6 D 68 N.s5s6.04
Hydrophobic TM5 P 258 5x71 s17s18 V 315 C.s17s18.40
Aromatic TM5 R 255 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 R 255 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 R 255 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM2 N 93 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 P 258 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM3 R 159 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 159 3x50 s5s6 L 72 N.s5s6.08
Polar TM5 K 251 5x64 s15s16 F 245 C.s15s16.03
Aromatic TM5 K 251 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 K 251 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 K 251 5x64 s15s16 F 245 C.s15s16.03
Polar H8 H 339 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic H8 H 339 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic TM2 T 95 2x39 s5s6 V 71 N.s5s6.07
Ionic TM6 R 272 6x29 s5s6 D 70 N.s5s6.06
Polar TM6 R 272 6x29 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 R 272 6x29 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 L 163 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 L 163 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 R 170 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 170 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 P 166 34x50 s15s16 F 245 C.s15s16.03
Hydrophobic TM4 S 172 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 S 172 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM6 R 272 6x29 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 L 163 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 L 163 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 L 167 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 L 167 34x51 S16 A 248 C.S16.01
Hydrophobic TM3 L 163 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 L 163 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 P 166 34x50 s5s6 L 69 N.s5s6.05
Hydrophobic ICL3 T 262 - S6 I 82 N.S6.07
Hydrophobic ICL2 P 166 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 166 34x50 S5 Y 64 N.S5.12
Polar ICL2 R 168 34x52 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 168 34x52 s5s6 R 66 N.s5s6.02
Polar TM5 R 255 5x68 S6 R 77 N.S6.02
Van-der-waals TM5 R 255 5x68 S6 R 77 N.S6.02
Hydrophobic TM5 G 259 5x72 S6 L 80 N.S6.05
Hydrophobic TM5 V 257 5x70 S6 K 78 N.S6.03
Van-der-waals TM5 V 257 5x70 S6 K 78 N.S6.03
Polar TM6 T 276 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 T 276 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 276 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM7 L 338 7x56 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 L 338 7x56 s5s6 L 72 N.s5s6.08