Beta-arrestin-2 - GPR65 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR65 80.8
Beta-arrestin-2 80.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 120 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 120 34x51 S16 Y 250 C.S16.03
Hydrophobic TM6 L 228 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 I 224 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 A 115 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 F 123 34x54 s8s9 G 138 N.s8s9.08
Van-der-waals ICL2 F 123 34x54 s8s9 G 138 N.s8s9.08
Van-der-waals ICL3 N 213 - s15s16 L 244 C.s15s16.02
Hydrophobic ICL3 N 213 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 N 213 - s15s16 F 245 C.s15s16.03
Hydrophobic TM3 A 115 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 115 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 L 227 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 227 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic ICL3 A 215 - S6 K 78 N.S6.03
Van-der-waals ICL3 A 215 - S6 K 78 N.S6.03
Hydrophobic TM3 R 112 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 112 3x50 s5s6 L 72 N.s5s6.08
Polar ICL3 A 215 - s15s16 L 244 C.s15s16.02
Hydrophobic ICL3 A 215 - s15s16 L 244 C.s15s16.02
Hydrophobic C-term V 325 - s9s10 S 159 N.s9s10.10
Van-der-waals C-term V 325 - s9s10 S 159 N.s9s10.10
Polar C-term K 328 - S6 R 77 N.S6.02
Hydrophobic C-term K 328 - S6 R 77 N.S6.02
Van-der-waals C-term K 328 - S6 R 77 N.S6.02
Hydrophobic TM3 V 116 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 V 116 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic C-term R 321 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term R 321 - s9s10 K 161 N.s9s10.12
Hydrophobic ICL2 L 120 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 120 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 F 123 34x54 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 F 123 34x54 s8s9 D 136 N.s8s9.06
Hydrophobic TM3 A 115 3x53 S6 F 76 N.S6.01
Hydrophobic TM6 I 231 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic C-term T 327 - s9s10 K 158 N.s9s10.09
Hydrophobic TM3 V 116 3x54 S6 F 76 N.S6.01
Hydrophobic ICL3 A 215 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 A 215 - s15s16 F 245 C.s15s16.03
Hydrophobic C-term I 322 - s9s10 H 160 N.s9s10.11
Van-der-waals C-term I 322 - s9s10 H 160 N.s9s10.11
Hydrophobic TM3 V 116 3x54 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 112 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 112 3x50 s5s6 V 71 N.s5s6.07
Polar ICL3 K 214 - s15s16 L 244 C.s15s16.02
Hydrophobic ICL3 K 214 - s15s16 L 244 C.s15s16.02
Van-der-waals ICL3 K 214 - s15s16 L 244 C.s15s16.02
Polar ICL3 K 214 - S6 K 78 N.S6.03
Van-der-waals ICL3 K 214 - S6 K 78 N.S6.03
Polar ICL2 R 126 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 126 34x57 s5s6 R 66 N.s5s6.02
Ionic TM2 E 48 2x38 s5s6 R 66 N.s5s6.02
Polar TM2 E 48 2x38 s5s6 R 66 N.s5s6.02
Van-der-waals TM2 E 48 2x38 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 F 123 34x54 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 F 123 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 P 119 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 119 34x50 S5 Y 64 N.S5.12
Hydrophobic TM5 V 206 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 R 126 34x57 s5s6 L 69 N.s5s6.05
Van-der-waals ICL2 R 126 34x57 s5s6 L 69 N.s5s6.05
Polar TM6 E 220 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 E 220 6x29 s5s6 S 75 N.s5s6.11
Polar H8 E 295 8x48 s5s6 D 70 N.s5s6.06
Ionic ICL3 K 214 - s17s18 E 314 C.s17s18.39
Polar ICL3 K 214 - s17s18 E 314 C.s17s18.39
Hydrophobic ICL3 K 214 - s17s18 E 314 C.s17s18.39
Van-der-waals ICL3 K 214 - s17s18 E 314 C.s17s18.39
Polar C-term R 317 - s9s10 R 162 N.s9s10.13
Van-der-waals C-term R 317 - s9s10 R 162 N.s9s10.13
Polar C-term R 321 - s1s2 P 15 N.s1s2.02
Hydrophobic C-term R 321 - s1s2 P 15 N.s1s2.02
Van-der-waals C-term R 321 - s1s2 P 15 N.s1s2.02
Polar C-term S 324 - s9s10 K 161 N.s9s10.12
Hydrophobic C-term S 324 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term S 324 - s9s10 K 161 N.s9s10.12
Hydrophobic TM5 V 210 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 F 123 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 F 123 34x54 s5s6 R 66 N.s5s6.02
Polar C-term S 324 - S10 R 166 N.S10.03
Van-der-waals C-term L 333 - S6 I 82 N.S6.07
Polar C-term K 328 - s5s6 S 75 N.s5s6.11
Hydrophobic C-term K 328 - s5s6 S 75 N.s5s6.11
Van-der-waals C-term K 328 - s5s6 S 75 N.s5s6.11
Hydrophobic ICL2 L 120 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 L 120 34x51 S15 I 242 C.S15.14
Hydrophobic ICL2 L 120 34x51 S9 C 141 N.S9.01
Hydrophobic TM6 I 224 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 I 224 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic C-term R 321 - s9s10 R 162 N.s9s10.13
Hydrophobic C-term Q 318 - s9s10 R 162 N.s9s10.13
Van-der-waals C-term Q 318 - s9s10 R 162 N.s9s10.13
Hydrophobic ICL2 F 123 34x54 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 F 123 34x54 s8s9 E 135 N.s8s9.05
Hydrophobic ICL3 T 216 - s5s6 L 74 N.s5s6.10
Polar H8 T 296 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 T 296 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 T 296 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 L 120 34x51 S8 L 130 N.S8.03
Van-der-waals ICL2 L 120 34x51 S8 L 130 N.S8.03